GO Annotations Graph

• Symbol: Mapkapk2
• Name: MAP kinase-activated protein kinase 2
• ID: MGI:109298

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0005524	ATP binding	IEA	J:72247
Molecular Function	GO:0009931	calcium-dependent protein serine/threonine kinase activity	IBA	J:265628
Molecular Function	GO:0005516	calmodulin binding	IBA	J:265628
Molecular Function	GO:0004683	calmodulin-dependent protein kinase activity	IBA	J:265628
Molecular Function	GO:0016301	kinase activity	IEA	J:60000
Molecular Function	GO:0051019	mitogen-activated protein kinase binding	IBA	J:265628
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:148784
Molecular Function	GO:0005515	protein binding	IPI	J:126340
Molecular Function	GO:0004672	protein kinase activity	IEA	J:72247
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IDA	J:180488
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IDA	J:180499
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IDA	J:126340
Molecular Function	GO:0004674	protein serine/threonine kinase activity	ISO	J:73065
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IDA	J:204512
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Cellular Component	GO:0005813	centrosome	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IDA	J:180499
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005737	cytoplasm	IDA	J:94780
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IDA	J:180499
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0005634	nucleus	IDA	J:94780
Biological Process	GO:0070935	3'-UTR-mediated mRNA stabilization	ISO	J:164563
Biological Process	GO:0035924	cellular response to vascular endothelial growth factor stimulus	ISO	J:164563
Biological Process	GO:0035924	cellular response to vascular endothelial growth factor stimulus	IBA	J:265628
Biological Process	GO:0006974	DNA damage response	ISO	J:164563
Biological Process	GO:0006954	inflammatory response	IMP	J:59678
Biological Process	GO:0006954	inflammatory response	IBA	J:265628
Biological Process	GO:0048839	inner ear development	IDA	J:174607
Biological Process	GO:0035556	intracellular signal transduction	IBA	J:265628
Biological Process	GO:0010934	macrophage cytokine production	IMP	J:204512
Biological Process	GO:0044351	macropinocytosis	IMP	J:126340
Biological Process	GO:0048255	mRNA stabilization	IMP	J:74321
Biological Process	GO:0038066	p38MAPK cascade	IMP	J:204512
Biological Process	GO:0018105	peptidyl-serine phosphorylation	ISO	J:164563
Biological Process	GO:0018105	peptidyl-serine phosphorylation	IBA	J:265628
Biological Process	GO:0016310	phosphorylation	IEA	J:60000
Biological Process	GO:0060907	positive regulation of macrophage cytokine production	IMP	J:204512
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	IMP	J:204512
Biological Process	GO:0046777	protein autophosphorylation	IBA	J:265628
Biological Process	GO:0006468	protein phosphorylation	IDA	J:180499
Biological Process	GO:0032675	regulation of interleukin-6 production	IMP	J:59678
Biological Process	GO:0032680	regulation of tumor necrosis factor production	ISO	J:164563
Biological Process	GO:0032680	regulation of tumor necrosis factor production	IMP	J:59678
Biological Process	GO:0034097	response to cytokine	ISO	J:164563
Biological Process	GO:0034097	response to cytokine	IBA	J:265628
Biological Process	GO:0032496	response to lipopolysaccharide	IMP	J:59678
Biological Process	GO:0032496	response to lipopolysaccharide	IMP	J:126340
Biological Process	GO:0002224	toll-like receptor signaling pathway	IMP	J:126340
Biological Process	GO:0002224	toll-like receptor signaling pathway	IBA	J:265628
Biological Process	GO:0032640	tumor necrosis factor production	IMP	J:204512
Biological Process	GO:0048010	vascular endothelial growth factor receptor signaling pathway	ISO	J:164563
Biological Process	GO:0048010	vascular endothelial growth factor receptor signaling pathway	IBA	J:265628