GO Annotations Graph

• Symbol: Fadd
• Name: Fas associated via death domain
• ID: MGI:109324

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0089720	caspase binding	ISO	J:164563
Molecular Function	GO:0089720	caspase binding	IBA	J:265628
Molecular Function	GO:0035877	death effector domain binding	ISO	J:164563
Molecular Function	GO:0005123	death receptor binding	ISO	J:155856
Molecular Function	GO:0005123	death receptor binding	IBA	J:265628
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0060090	molecular adaptor activity	ISO	J:164563
Molecular Function	GO:0002020	protease binding	ISO	J:164563
Molecular Function	GO:0002020	protease binding	ISO	J:155856
Molecular Function	GO:0005515	protein binding	IPI	J:228302
Molecular Function	GO:0005515	protein binding	IPI	J:152731
Molecular Function	GO:0005515	protein binding	IPI	J:171939
Molecular Function	GO:0005515	protein binding	IPI	J:203409
Molecular Function	GO:0005515	protein binding	IPI	J:217283
Molecular Function	GO:0005515	protein binding	IPI	J:200420
Molecular Function	GO:0005515	protein binding	IPI	J:226752
Molecular Function	GO:0005515	protein binding	IPI	J:265780
Molecular Function	GO:0005515	protein binding	IPI	J:248272
Molecular Function	GO:0005515	protein binding	IPI	J:209137
Molecular Function	GO:0005515	protein binding	IPI	J:139785
Molecular Function	GO:0005515	protein binding	IPI	J:279494
Molecular Function	GO:0005515	protein binding	IPI	J:114810
Molecular Function	GO:0005515	protein binding	IPI	J:170814
Molecular Function	GO:0005515	protein binding	IPI	J:182381
Molecular Function	GO:0005515	protein binding	IPI	J:281201
Molecular Function	GO:0005515	protein binding	IPI	J:251915
Molecular Function	GO:0005515	protein binding	IPI	J:97777
Molecular Function	GO:0005515	protein binding	IPI	J:101402
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:155856
Molecular Function	GO:0033612	receptor serine/threonine kinase binding	ISO	J:155856
Molecular Function	GO:0005164	tumor necrosis factor receptor binding	ISO	J:155856
Molecular Function	GO:0032813	tumor necrosis factor receptor superfamily binding	ISO	J:164563
Cellular Component	GO:0031265	CD95 death-inducing signaling complex	ISO	J:155856
Cellular Component	GO:0031265	CD95 death-inducing signaling complex	ISO	J:164563
Cellular Component	GO:0031265	CD95 death-inducing signaling complex	IBA	J:265628
Cellular Component	GO:0044297	cell body	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0031264	death-inducing signaling complex	ISO	J:155856
Cellular Component	GO:0031264	death-inducing signaling complex	ISO	J:164563
Cellular Component	GO:0045121	membrane raft	ISO	J:155856
Cellular Component	GO:0043005	neuron projection	ISO	J:155856
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0032991	protein-containing complex	ISO	J:155856
Cellular Component	GO:0097342	ripoptosome	ISO	J:164563
Biological Process	GO:0097202	activation of cysteine-type endopeptidase activity	ISO	J:164563
Biological Process	GO:0006915	apoptotic process	ISO	J:164563
Biological Process	GO:0097190	apoptotic signaling pathway	ISO	J:164563
Biological Process	GO:0048738	cardiac muscle tissue development	TAS	J:180458
Biological Process	GO:0071550	death-inducing signaling complex assembly	ISO	J:164563
Biological Process	GO:0051607	defense response to virus	ISO	J:164563
Biological Process	GO:0097191	extrinsic apoptotic signaling pathway	ISO	J:164563
Biological Process	GO:0097191	extrinsic apoptotic signaling pathway	IBA	J:265628
Biological Process	GO:0097191	extrinsic apoptotic signaling pathway	IDA	J:113782
Biological Process	GO:0097191	extrinsic apoptotic signaling pathway	IGI	J:101402
Biological Process	GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand	IMP	J:85525
Biological Process	GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors	ISO	J:164563
Biological Process	GO:0002376	immune system process	IEA	J:60000
Biological Process	GO:0045087	innate immune response	TAS	J:180458
Biological Process	GO:0048535	lymph node development	IGI	J:176448
Biological Process	GO:0097049	motor neuron apoptotic process	IMP	J:85525
Biological Process	GO:0097527	necroptotic signaling pathway	ISO	J:164563
Biological Process	GO:0070236	negative regulation of activation-induced cell death of T cells	IMP	J:176448
Biological Process	GO:0060546	negative regulation of necroptotic process	IGI	J:202809
Biological Process	GO:0060546	negative regulation of necroptotic process	IGI	J:196028
Biological Process	GO:0042104	positive regulation of activated T cell proliferation	IMP	J:176448
Biological Process	GO:0002821	positive regulation of adaptive immune response	IMP	J:176448
Biological Process	GO:0043065	positive regulation of apoptotic process	ISO	J:164563
Biological Process	GO:2000454	positive regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation	IMP	J:176448
Biological Process	GO:2001238	positive regulation of extrinsic apoptotic signaling pathway	ISO	J:164563
Biological Process	GO:2001238	positive regulation of extrinsic apoptotic signaling pathway	IGI	J:196028
Biological Process	GO:2001238	positive regulation of extrinsic apoptotic signaling pathway	IGI	J:196028
Biological Process	GO:0045089	positive regulation of innate immune response	IBA	J:265628
Biological Process	GO:0032757	positive regulation of interleukin-8 production	ISO	J:164563
Biological Process	GO:0045651	positive regulation of macrophage differentiation	ISO	J:164563
Biological Process	GO:0045862	positive regulation of proteolysis	ISO	J:164563
Biological Process	GO:0001916	positive regulation of T cell mediated cytotoxicity	IMP	J:176448
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	ISO	J:164563
Biological Process	GO:0060340	positive regulation of type I interferon-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0032729	positive regulation of type II interferon production	IMP	J:176448
Biological Process	GO:0042981	regulation of apoptotic process	IEA	J:72247
Biological Process	GO:0060544	regulation of necroptotic process	ISO	J:155856
Biological Process	GO:0043278	response to morphine	ISO	J:155856
Biological Process	GO:0007165	signal transduction	IEA	J:72247
Biological Process	GO:0048536	spleen development	IGI	J:176448
Biological Process	GO:0030217	T cell differentiation	TAS	J:180458
Biological Process	GO:0033077	T cell differentiation in thymus	IMP	J:176448
Biological Process	GO:0043029	T cell homeostasis	IMP	J:176448
Biological Process	GO:0048538	thymus development	IGI	J:176448
Biological Process	GO:0036462	TRAIL-activated apoptotic signaling pathway	ISO	J:164563