Brca2 GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

Brca2
breast cancer 2, early onset
MGI:109337

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003677	DNA binding	IEA	J:60000
Molecular Function	GO:0043015	gamma-tubulin binding	ISO	J:164563
Molecular Function	GO:0010484	histone H3 acetyltransferase activity	ISO	J:164563
Molecular Function	GO:0010485	histone H4 acetyltransferase activity	ISO	J:164563
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0002020	protease binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:273173
Molecular Function	GO:0005515	protein binding	IPI	J:294372
Molecular Function	GO:0005515	protein binding	IPI	J:291970
Molecular Function	GO:0005515	protein binding	IPI	J:292036
Molecular Function	GO:0005515	protein binding	IPI	J:303558
Molecular Function	GO:0005515	protein binding	IPI	J:84892
Molecular Function	GO:0005515	protein binding	IPI	J:95301
Molecular Function	GO:0005515	protein binding	ISO	J:113839
Molecular Function	GO:0005515	protein binding	IPI	J:39764
Molecular Function	GO:0005515	protein binding	IPI	J:114800
Molecular Function	GO:0005515	protein binding	IPI	J:72374
Molecular Function	GO:0003697	single-stranded DNA binding	ISO	J:155856
Molecular Function	GO:0003697	single-stranded DNA binding	ISO	J:164563
Cellular Component	GO:0033593	BRCA2-MAGE-D1 complex	ISO	J:164563
Cellular Component	GO:0005813	centrosome	ISO	J:164563
Cellular Component	GO:0005694	chromosome	IDA	J:273173
Cellular Component	GO:0000781	chromosome, telomeric region	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IDA	J:74101
Cellular Component	GO:0005856	cytoskeleton	IEA	J:60000
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:1990391	DNA repair complex	ISO	J:164563
Cellular Component	GO:0000800	lateral element	ISO	J:113839
Cellular Component	GO:0000152	nuclear ubiquitin ligase complex	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-912421
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-912431
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-912462
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-912487
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0005634	nucleus	IDA	J:74101
Cellular Component	GO:0005634	nucleus	IDA	J:72374
Cellular Component	GO:0032991	protein-containing complex	ISO	J:164563
Cellular Component	GO:0032991	protein-containing complex	ISO	J:113389
Cellular Component	GO:0030141	secretory granule	ISO	J:164563
Biological Process	GO:0007420	brain development	IMP	J:122559
Biological Process	GO:0007049	cell cycle	IEA	J:60000
Biological Process	GO:0008283	cell population proliferation	IMP	J:122559
Biological Process	GO:0008283	cell population proliferation	IMP	J:40594
Biological Process	GO:0071479	cellular response to ionizing radiation	ISO	J:164563
Biological Process	GO:0090398	cellular senescence	IMP	J:49518
Biological Process	GO:0090398	cellular senescence	IMP	J:49518
Biological Process	GO:0051298	centrosome duplication	ISO	J:164563
Biological Process	GO:0043009	chordate embryonic development	IMP	J:40594
Biological Process	GO:0051276	chromosome organization	IMP	J:47362
Biological Process	GO:0051276	chromosome organization	IMP	J:144998
Biological Process	GO:0006974	DNA damage response	IDA	J:141600
Biological Process	GO:0006978	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator	IMP	J:37362
Biological Process	GO:0006310	DNA recombination	ISO	J:155856
Biological Process	GO:0006281	DNA repair	IEA	J:60000
Biological Process	GO:0006281	DNA repair	IEA	J:72247
Biological Process	GO:0006302	double-strand break repair	ISO	J:164563
Biological Process	GO:0006302	double-strand break repair	IMP	J:44386
Biological Process	GO:0006302	double-strand break repair	IMP	J:122559
Biological Process	GO:0000724	double-strand break repair via homologous recombination	ISO	J:164563
Biological Process	GO:0000724	double-strand break repair via homologous recombination	IBA	J:265628
Biological Process	GO:0000724	double-strand break repair via homologous recombination	IMP	J:94149
Biological Process	GO:0000724	double-strand break repair via homologous recombination	IMP	J:94149
Biological Process	GO:0070200	establishment of protein localization to telomere	IDA	J:228560
Biological Process	GO:0070200	establishment of protein localization to telomere	ISO	J:164563
Biological Process	GO:0008585	female gonad development	IMP	J:44386
Biological Process	GO:0071425	hematopoietic stem cell proliferation	IMP	J:144998
Biological Process	GO:0030097	hemopoiesis	IMP	J:144998
Biological Process	GO:0035518	histone H2A monoubiquitination	NAS	J:320082
Biological Process	GO:0031619	homologous chromosome orientation involved in meiotic metaphase I plate congression	ISO	J:155856
Biological Process	GO:0001833	inner cell mass cell proliferation	IMP	J:40595
Biological Process	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	IGI	J:122559
Biological Process	GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	IGI	J:122559
Biological Process	GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	IMP	J:98772
Biological Process	GO:0007141	male meiosis I	IDA	J:292036
Biological Process	GO:0007141	male meiosis I	IMP	J:87231
Biological Process	GO:0030879	mammary gland development	ISO	J:155856
Biological Process	GO:1990426	mitotic recombination-dependent replication fork processing	ISO	J:164563
Biological Process	GO:0035264	multicellular organism growth	ISO	J:155856
Biological Process	GO:0033600	negative regulation of mammary gland epithelial cell proliferation	ISO	J:164563
Biological Process	GO:0006289	nucleotide-excision repair	ISO	J:164563
Biological Process	GO:0001556	oocyte maturation	IMP	J:87231
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0045931	positive regulation of mitotic cell cycle	IMP	J:47362
Biological Process	GO:0051865	protein autoubiquitination	NAS	J:320082
Biological Process	GO:0032465	regulation of cytokinesis	IMP	J:93261
Biological Process	GO:2000001	regulation of DNA damage checkpoint	NAS	J:320084
Biological Process	GO:0006355	regulation of DNA-templated transcription	IBA	J:265628
Biological Process	GO:0031297	replication fork processing	IMP	J:87195
Biological Process	GO:0010332	response to gamma radiation	IMP	J:49518
Biological Process	GO:0010332	response to gamma radiation	IMP	J:39764
Biological Process	GO:0010332	response to gamma radiation	IMP	J:49518
Biological Process	GO:0010225	response to UV-C	IMP	J:47362
Biological Process	GO:0010165	response to X-ray	IMP	J:144998
Biological Process	GO:0010165	response to X-ray	IMP	J:44386
Biological Process	GO:0010165	response to X-ray	IMP	J:47362
Biological Process	GO:0007283	spermatogenesis	ISO	J:155856
Biological Process	GO:0007283	spermatogenesis	IMP	J:44386
Biological Process	GO:0072089	stem cell proliferation	IMP	J:44386
Biological Process	GO:0072089	stem cell proliferation	IMP	J:47362
Biological Process	GO:0000722	telomere maintenance via recombination	IGI	J:228560

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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