Pitx2 GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

Pitx2
paired-like homeodomain transcription factor 2
MGI:109340

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003682	chromatin binding	IDA	J:125640
Molecular Function	GO:0003682	chromatin binding	IDA	J:67321
Molecular Function	GO:0031490	chromatin DNA binding	IDA	J:168032
Molecular Function	GO:0031490	chromatin DNA binding	IDA	J:168032
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	ISO	J:155856
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IDA	J:80691
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IDA	J:67321
Molecular Function	GO:0003700	DNA-binding transcription factor activity	ISO	J:73065
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	ISO	J:164563
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	J:265628
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IDA	J:168032
Molecular Function	GO:0140297	DNA-binding transcription factor binding	ISO	J:164563
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	ISO	J:164563
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0051219	phosphoprotein binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:235748
Molecular Function	GO:0005515	protein binding	IPI	J:166613
Molecular Function	GO:0005515	protein binding	IPI	J:80691
Molecular Function	GO:0005515	protein binding	IPI	J:80691
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:164563
Molecular Function	GO:0043021	ribonucleoprotein complex binding	ISO	J:164563
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO	J:155856
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA	J:265628
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	ISO	J:164563
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	ISO	J:164563
Molecular Function	GO:0043565	sequence-specific DNA binding	IDA	J:166613
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	ISO	J:164563
Molecular Function	GO:0000976	transcription cis-regulatory region binding	ISO	J:164563
Molecular Function	GO:0000976	transcription cis-regulatory region binding	ISO	J:164563
Molecular Function	GO:0008134	transcription factor binding	ISO	J:73065
Cellular Component	GO:0005737	cytoplasm	IDA	J:150130
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0005634	nucleus	IDA	J:62068
Cellular Component	GO:0005634	nucleus	IDA	J:150130
Cellular Component	GO:0005634	nucleus	IDA	J:62068
Cellular Component	GO:0005667	transcription regulator complex	IDA	J:80691
Cellular Component	GO:0005667	transcription regulator complex	ISO	J:73065
Biological Process	GO:0009653	anatomical structure morphogenesis	IBA	J:265628
Biological Process	GO:0009653	anatomical structure morphogenesis	IMP	J:57674
Biological Process	GO:0009887	animal organ morphogenesis	IMP	J:55455
Biological Process	GO:0055009	atrial cardiac muscle tissue morphogenesis	IMP	J:69854
Biological Process	GO:0003171	atrioventricular valve development	IMP	J:147648
Biological Process	GO:0001569	branching involved in blood vessel morphogenesis	IMP	J:79853
Biological Process	GO:0001569	branching involved in blood vessel morphogenesis	IMP	J:79853
Biological Process	GO:0043010	camera-type eye development	ISO	J:164563
Biological Process	GO:0055007	cardiac muscle cell differentiation	IMP	J:133688
Biological Process	GO:0055007	cardiac muscle cell differentiation	IMP	J:79853
Biological Process	GO:0048738	cardiac muscle tissue development	IMP	J:119307
Biological Process	GO:0003253	cardiac neural crest cell migration involved in outflow tract morphogenesis	IMP	J:80691
Biological Process	GO:0061325	cell proliferation involved in outflow tract morphogenesis	IMP	J:80691
Biological Process	GO:0061325	cell proliferation involved in outflow tract morphogenesis	IMP	J:119307
Biological Process	GO:0035993	deltoid tuberosity development	ISO	J:164563
Biological Process	GO:0035993	deltoid tuberosity development	IMP	J:135637
Biological Process	GO:0007368	determination of left/right symmetry	IMP	J:49484
Biological Process	GO:0007368	determination of left/right symmetry	IMP	J:204986
Biological Process	GO:0007368	determination of left/right symmetry	IMP	J:51160
Biological Process	GO:0007368	determination of left/right symmetry	IMP	J:79853
Biological Process	GO:0007368	determination of left/right symmetry	IMP	J:51160
Biological Process	GO:0007368	determination of left/right symmetry	IMP	J:55455
Biological Process	GO:0007368	determination of left/right symmetry	IMP	J:57673
Biological Process	GO:0007368	determination of left/right symmetry	IMP	J:69854
Biological Process	GO:0055123	digestive system development	IMP	J:69854
Biological Process	GO:0031076	embryonic camera-type eye development	IMP	J:51160
Biological Process	GO:0031076	embryonic camera-type eye development	IMP	J:55455
Biological Process	GO:0031076	embryonic camera-type eye development	IMP	J:51160
Biological Process	GO:0048557	embryonic digestive tract morphogenesis	IMP	J:175282
Biological Process	GO:0060971	embryonic heart tube left/right pattern formation	IMP	J:133688
Biological Process	GO:0035116	embryonic hindlimb morphogenesis	IGI	J:131535
Biological Process	GO:0061031	endodermal digestive tract morphogenesis	IMP	J:175282
Biological Process	GO:0002074	extraocular skeletal muscle development	IMP	J:168032
Biological Process	GO:0002074	extraocular skeletal muscle development	IMP	J:108510
Biological Process	GO:0002074	extraocular skeletal muscle development	IMP	J:168032
Biological Process	GO:0007507	heart development	IMP	J:80691
Biological Process	GO:0007507	heart development	IMP	J:55455
Biological Process	GO:0007507	heart development	IMP	J:55455
Biological Process	GO:0007507	heart development	IGI	J:107397
Biological Process	GO:0007507	heart development	IMP	J:51160
Biological Process	GO:0007507	heart development	IMP	J:51160
Biological Process	GO:0007507	heart development	IMP	J:55455
Biological Process	GO:0007507	heart development	IMP	J:57674
Biological Process	GO:0007507	heart development	IMP	J:69854
Biological Process	GO:0007507	heart development	IMP	J:51160
Biological Process	GO:0007507	heart development	IMP	J:51160
Biological Process	GO:0007507	heart development	IMP	J:55455
Biological Process	GO:0007507	heart development	IMP	J:51160
Biological Process	GO:0007507	heart development	IMP	J:79853
Biological Process	GO:0007507	heart development	IMP	J:51160
Biological Process	GO:0021855	hypothalamus cell migration	IMP	J:135239
Biological Process	GO:0001701	in utero embryonic development	IMP	J:69854
Biological Process	GO:0061072	iris morphogenesis	ISO	J:164563
Biological Process	GO:0060460	left lung morphogenesis	IMP	J:69854
Biological Process	GO:0070986	left/right axis specification	IMP	J:92872
Biological Process	GO:0030324	lung development	IMP	J:51160
Biological Process	GO:0030324	lung development	IMP	J:55455
Biological Process	GO:0030324	lung development	IMP	J:57673
Biological Process	GO:0030324	lung development	IMP	J:51160
Biological Process	GO:0030324	lung development	IMP	J:131535
Biological Process	GO:0007275	multicellular organism development	IEA	J:60000
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0001764	neuron migration	IMP	J:135239
Biological Process	GO:0042476	odontogenesis	ISO	J:164563
Biological Process	GO:0042476	odontogenesis	IMP	J:51160
Biological Process	GO:0042476	odontogenesis	IMP	J:57673
Biological Process	GO:0042476	odontogenesis	IMP	J:51160
Biological Process	GO:0021983	pituitary gland development	IMP	J:57673
Biological Process	GO:0021983	pituitary gland development	IMP	J:51160
Biological Process	GO:0021983	pituitary gland development	IMP	J:51160
Biological Process	GO:0043388	positive regulation of DNA binding	IDA	J:168032
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IMP	J:125640
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:155856
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:67321
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:136678
Biological Process	GO:0003350	pulmonary myocardium development	IMP	J:141338
Biological Process	GO:0060577	pulmonary vein morphogenesis	IMP	J:69854
Biological Process	GO:0030334	regulation of cell migration	IMP	J:79853
Biological Process	GO:0042127	regulation of cell population proliferation	IMP	J:80691
Biological Process	GO:0006355	regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	ISO	J:73065
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	ISO	J:73065
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IDA	J:80691
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IGI	J:166613
Biological Process	GO:0007519	skeletal muscle tissue development	IMP	J:55455
Biological Process	GO:0048536	spleen development	IMP	J:92872
Biological Process	GO:0021763	subthalamic nucleus development	IMP	J:135239
Biological Process	GO:0060578	superior vena cava morphogenesis	IMP	J:69854
Biological Process	GO:0035886	vascular associated smooth muscle cell differentiation	IMP	J:136678
Biological Process	GO:0001570	vasculogenesis	IMP	J:131535
Biological Process	GO:0055015	ventricular cardiac muscle cell development	IMP	J:147648
Biological Process	GO:0060412	ventricular septum morphogenesis	IMP	J:147648
Biological Process	GO:0016055	Wnt signaling pathway	IDA	J:80691

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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