GO Annotations Graph

• Symbol: Ucp2
• Name: uncoupling protein 2 (mitochondrial, proton carrier)
• ID: MGI:109354

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0015297	antiporter activity	ISO	J:164563
Molecular Function	GO:0015183	L-aspartate transmembrane transporter activity	ISO	J:164563
Molecular Function	GO:0015140	malate transmembrane transporter activity	ISO	J:164563
Molecular Function	GO:0015131	oxaloacetate transmembrane transporter activity	ISO	J:164563
Molecular Function	GO:0017077	oxidative phosphorylation uncoupler activity	IBA	J:265628
Molecular Function	GO:0140787	phosphate ion uniporter activity	ISO	J:164563
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:164563
Molecular Function	GO:0015078	proton transmembrane transporter activity	ISO	J:164563
Molecular Function	GO:0008271	secondary active sulfate transmembrane transporter activity	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005743	mitochondrial inner membrane	IEA	J:60000
Cellular Component	GO:0031966	mitochondrial membrane	IDA	J:319416
Cellular Component	GO:0005739	mitochondrion	ISO	J:164563
Cellular Component	GO:0005739	mitochondrion	ISO	J:155856
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005739	mitochondrion	HDA	J:151002
Cellular Component	GO:0005739	mitochondrion	ISA	J:38702
Biological Process	GO:1990845	adaptive thermogenesis	IBA	J:265628
Biological Process	GO:0015740	C4-dicarboxylate transport	ISO	J:164563
Biological Process	GO:0071333	cellular response to glucose stimulus	IMP	J:230799
Biological Process	GO:0006541	glutamine metabolic process	ISO	J:164563
Biological Process	GO:0006096	glycolytic process	ISO	J:164563
Biological Process	GO:0030225	macrophage differentiation	IMP	J:319416
Biological Process	GO:0000266	mitochondrial fission	IMP	J:230799
Biological Process	GO:1990542	mitochondrial transmembrane transport	ISO	J:164563
Biological Process	GO:1990542	mitochondrial transmembrane transport	IBA	J:265628
Biological Process	GO:0006839	mitochondrial transport	ISO	J:155856
Biological Process	GO:0043066	negative regulation of apoptotic process	ISO	J:155856
Biological Process	GO:0061179	negative regulation of insulin secretion involved in cellular response to glucose stimulus	ISO	J:155856
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	IMP	J:187672
Biological Process	GO:0010942	positive regulation of cell death	ISO	J:155856
Biological Process	GO:0120162	positive regulation of cold-induced thermogenesis	IMP	J:249876
Biological Process	GO:0072593	reactive oxygen species metabolic process	IMP	J:230799
Biological Process	GO:0051881	regulation of mitochondrial membrane potential	IMP	J:187412
Biological Process	GO:0009409	response to cold	IBA	J:265628
Biological Process	GO:0001666	response to hypoxia	ISO	J:164563
Biological Process	GO:0000303	response to superoxide	ISO	J:155856