GO Annotations Graph

• Symbol: Stx1a
• Name: syntaxin 1A (brain)
• ID: MGI:109355

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0043008	ATP-dependent protein binding	ISO	J:155856
Molecular Function	GO:0019855	calcium channel inhibitor activity	IMP	J:119891
Molecular Function	GO:0048306	calcium-dependent protein binding	ISO	J:155856
Molecular Function	GO:0019869	chloride channel inhibitor activity	ISO	J:164563
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0019900	kinase binding	ISO	J:164563
Molecular Function	GO:0017022	myosin binding	ISO	J:155856
Molecular Function	GO:0032028	myosin head/neck binding	ISO	J:155856
Molecular Function	GO:0005515	protein binding	IPI	J:255335
Molecular Function	GO:0005515	protein binding	IPI	J:99919
Molecular Function	GO:0005515	protein binding	IPI	J:136786
Molecular Function	GO:0005515	protein binding	IPI	J:225864
Molecular Function	GO:0005515	protein binding	IPI	J:116097
Molecular Function	GO:0005515	protein binding	IPI	J:218865
Molecular Function	GO:0005515	protein binding	IPI	J:141196
Molecular Function	GO:0005515	protein binding	IPI	J:108786
Molecular Function	GO:0005515	protein binding	IPI	J:273533
Molecular Function	GO:0005515	protein binding	IPI	J:226387
Molecular Function	GO:0005515	protein binding	IPI	J:119733
Molecular Function	GO:0005515	protein binding	IPI	J:157584
Molecular Function	GO:0005515	protein binding	IPI	J:23761
Molecular Function	GO:0005515	protein binding	IPI	J:119891
Molecular Function	GO:0005515	protein binding	IPI	J:23761
Molecular Function	GO:0005515	protein binding	IPI	J:167753
Molecular Function	GO:0005515	protein binding	IPI	J:121567
Molecular Function	GO:0005515	protein binding	IPI	J:167753
Molecular Function	GO:0005515	protein binding	IPI	J:70673
Molecular Function	GO:0005515	protein binding	IPI	J:167753
Molecular Function	GO:0005515	protein binding	IPI	J:167753
Molecular Function	GO:0005515	protein binding	IPI	J:91698
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:155856
Molecular Function	GO:0030674	protein-macromolecule adaptor activity	ISO	J:155856
Molecular Function	GO:0005484	SNAP receptor activity	IBA	J:265628
Molecular Function	GO:0000149	SNARE binding	ISO	J:155856
Molecular Function	GO:0000149	SNARE binding	IBA	J:265628
Molecular Function	GO:0000149	SNARE binding	ISO	J:29256
Molecular Function	GO:0000149	SNARE binding	IDA	J:78421
Molecular Function	GO:0044325	transmembrane transporter binding	ISO	J:155856
Cellular Component	GO:0001669	acrosomal vesicle	EXP	J:108463
Cellular Component	GO:0042641	actomyosin	ISO	J:155856
Cellular Component	GO:0030424	axon	IDA	J:238447
Cellular Component	GO:0031410	cytoplasmic vesicle	IEA	J:60000
Cellular Component	GO:0012505	endomembrane system	IBA	J:265628
Cellular Component	GO:0098978	glutamatergic synapse	ISO	J:155856
Cellular Component	GO:0043229	intracellular organelle	ISO	J:155856
Cellular Component	GO:0016020	membrane	IDA	J:114833
Cellular Component	GO:0043005	neuron projection	IDA	J:99424
Cellular Component	GO:0043005	neuron projection	ISO	J:77234
Cellular Component	GO:0031965	nuclear membrane	IDA	J:106641
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	IDA	J:238447
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-216883
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-9664156
Cellular Component	GO:0005886	plasma membrane	IBA	J:265628
Cellular Component	GO:0005886	plasma membrane	IDA	J:119891
Cellular Component	GO:0005886	plasma membrane	TAS	J:78421
Cellular Component	GO:0014069	postsynaptic density	ISO	J:155856
Cellular Component	GO:0098839	postsynaptic density membrane	ISO	J:155856
Cellular Component	GO:0098793	presynapse	IDA	J:234628
Cellular Component	GO:0048787	presynaptic active zone membrane	ISO	J:155856
Cellular Component	GO:0048787	presynaptic active zone membrane	ISO	J:155856
Cellular Component	GO:0048787	presynaptic active zone membrane	IBA	J:265628
Cellular Component	GO:0042734	presynaptic membrane	ISO	J:155856
Cellular Component	GO:0042734	presynaptic membrane	ISO	J:155856
Cellular Component	GO:0032991	protein-containing complex	ISO	J:155856
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	ISO	J:155856
Cellular Component	GO:0030141	secretory granule	ISO	J:155856
Cellular Component	GO:0031201	SNARE complex	ISO	J:164563
Cellular Component	GO:0031201	SNARE complex	IBA	J:265628
Cellular Component	GO:0045202	synapse	IDA	J:234628
Cellular Component	GO:0008021	synaptic vesicle	IDA	J:141196
Cellular Component	GO:0008021	synaptic vesicle	IBA	J:265628
Cellular Component	GO:0030672	synaptic vesicle membrane	ISO	J:155856
Cellular Component	GO:0030672	synaptic vesicle membrane	ISO	J:155856
Cellular Component	GO:0030672	synaptic vesicle membrane	IDA	J:83886
Cellular Component	GO:0070044	synaptobrevin 2-SNAP-25-syntaxin-1a complex	ISO	J:155856
Cellular Component	GO:0070044	synaptobrevin 2-SNAP-25-syntaxin-1a complex	ISO	J:29256
Cellular Component	GO:0070044	synaptobrevin 2-SNAP-25-syntaxin-1a complex	IDA	J:167753
Cellular Component	GO:0070044	synaptobrevin 2-SNAP-25-syntaxin-1a complex	IDA	J:99424
Cellular Component	GO:0070032	synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex	ISO	J:29256
Cellular Component	GO:0070033	synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex	ISO	J:155856
Biological Process	GO:0017156	calcium-ion regulated exocytosis	IMP	J:119891
Biological Process	GO:0006887	exocytosis	IBA	J:265628
Biological Process	GO:0046879	hormone secretion	IMP	J:245492
Biological Process	GO:0030073	insulin secretion	IMP	J:134722
Biological Process	GO:0006886	intracellular protein transport	IBA	J:265628
Biological Process	GO:0098815	modulation of excitatory postsynaptic potential	ISO	J:155856
Biological Process	GO:0006836	neurotransmitter transport	IEA	J:60000
Biological Process	GO:0045956	positive regulation of calcium ion-dependent exocytosis	ISO	J:155856
Biological Process	GO:0033605	positive regulation of catecholamine secretion	ISO	J:155856
Biological Process	GO:2000463	positive regulation of excitatory postsynaptic potential	IGI	J:202743
Biological Process	GO:0045921	positive regulation of exocytosis	ISO	J:155856
Biological Process	GO:0001956	positive regulation of neurotransmitter secretion	ISO	J:155856
Biological Process	GO:0001956	positive regulation of neurotransmitter secretion	IGI	J:202743
Biological Process	GO:0010701	positive regulation of norepinephrine secretion	ISO	J:155856
Biological Process	GO:0072657	protein localization to membrane	ISO	J:155856
Biological Process	GO:0016925	protein sumoylation	ISO	J:164563
Biological Process	GO:0045055	regulated exocytosis	IMP	J:134722
Biological Process	GO:0017157	regulation of exocytosis	ISO	J:155856
Biological Process	GO:0010807	regulation of synaptic vesicle priming	IGI	J:202743
Biological Process	GO:0009629	response to gravity	ISO	J:155856
Biological Process	GO:0032940	secretion by cell	ISO	J:164563
Biological Process	GO:0035493	SNARE complex assembly	ISO	J:155856
Biological Process	GO:0048488	synaptic vesicle endocytosis	ISO	J:164563
Biological Process	GO:0016079	synaptic vesicle exocytosis	ISO	J:155856
Biological Process	GO:0016079	synaptic vesicle exocytosis	ISO	J:164563
Biological Process	GO:0016079	synaptic vesicle exocytosis	IDA	J:234628
Biological Process	GO:0016079	synaptic vesicle exocytosis	IDA	J:234628
Biological Process	GO:0016079	synaptic vesicle exocytosis	IMP	J:234628
Biological Process	GO:0031629	synaptic vesicle fusion to presynaptic active zone membrane	ISO	J:155856
Biological Process	GO:0031629	synaptic vesicle fusion to presynaptic active zone membrane	IBA	J:265628
Biological Process	GO:0048278	vesicle docking	IMP	J:134722
Biological Process	GO:0048278	vesicle docking	IBA	J:265628
Biological Process	GO:0016192	vesicle-mediated transport	IEA	J:72247