GO Annotations Graph

• Symbol: Esr2
• Name: estrogen receptor 2 (beta)
• ID: MGI:109392

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003677	DNA binding	IDA	J:38785
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	ISO	J:155856
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IEA	J:72247
Molecular Function	GO:0019899	enzyme binding	ISO	J:155856
Molecular Function	GO:0019899	enzyme binding	ISO	J:164563
Molecular Function	GO:1903924	estradiol binding	ISO	J:155856
Molecular Function	GO:0099130	estrogen binding	ISO	J:155856
Molecular Function	GO:0034056	estrogen response element binding	ISO	J:164563
Molecular Function	GO:0034056	estrogen response element binding	ISO	J:164563
Molecular Function	GO:0034056	estrogen response element binding	ISO	J:155856
Molecular Function	GO:0034056	estrogen response element binding	IBA	J:265628
Molecular Function	GO:1901363	heterocyclic compound binding	ISO	J:155856
Molecular Function	GO:0042562	hormone binding	ISO	J:155856
Molecular Function	GO:0008289	lipid binding	IEA	J:60000
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0030284	nuclear estrogen receptor activity	ISO	J:164563
Molecular Function	GO:0030284	nuclear estrogen receptor activity	ISO	J:155856
Molecular Function	GO:0030284	nuclear estrogen receptor activity	ISO	J:164563
Molecular Function	GO:0004879	nuclear receptor activity	ISO	J:164563
Molecular Function	GO:0003707	nuclear steroid receptor activity	ISO	J:155856
Molecular Function	GO:0097159	organic cyclic compound binding	ISO	J:155856
Molecular Function	GO:0042975	peroxisome proliferator activated receptor binding	ISO	J:155856
Molecular Function	GO:1990841	promoter-specific chromatin binding	ISO	J:155856
Molecular Function	GO:0005515	protein binding	IPI	J:173244
Molecular Function	GO:0005515	protein binding	IPI	J:73693
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO	J:164563
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO	J:155856
Molecular Function	GO:0043565	sequence-specific DNA binding	ISO	J:155856
Molecular Function	GO:0005496	steroid binding	ISO	J:155856
Molecular Function	GO:1990239	steroid hormone binding	ISO	J:155856
Molecular Function	GO:0008270	zinc ion binding	IEA	J:72247
Cellular Component	GO:0005929	cilium	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	IDA	J:85930
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	ISO	J:164563
Cellular Component	GO:0005739	mitochondrion	ISO	J:73065
Cellular Component	GO:0005739	mitochondrion	ISO	J:73065
Cellular Component	GO:0043005	neuron projection	ISO	J:155856
Cellular Component	GO:0043025	neuronal cell body	ISO	J:155856
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0005634	nucleus	IDA	J:89713
Cellular Component	GO:0005634	nucleus	IDA	J:85930
Cellular Component	GO:0005634	nucleus	IDA	J:85611
Cellular Component	GO:0043204	perikaryon	ISO	J:155856
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0032993	protein-DNA complex	ISO	J:155856
Biological Process	GO:0030521	androgen receptor signaling pathway	IMP	J:126711
Biological Process	GO:0030521	androgen receptor signaling pathway	IMP	J:126711
Biological Process	GO:0030521	androgen receptor signaling pathway	IMP	J:126711
Biological Process	GO:0001662	behavioral fear response	ISO	J:155856
Biological Process	GO:0007420	brain development	IMP	J:81418
Biological Process	GO:0008283	cell population proliferation	IGI	J:138676
Biological Process	GO:0071392	cellular response to estradiol stimulus	ISO	J:164563
Biological Process	GO:0071391	cellular response to estrogen stimulus	IBA	J:265628
Biological Process	GO:0060743	epithelial cell maturation involved in prostate gland development	IMP	J:91449
Biological Process	GO:0050673	epithelial cell proliferation	IMP	J:91449
Biological Process	GO:0050673	epithelial cell proliferation	IMP	J:126711
Biological Process	GO:0044849	estrous cycle	ISO	J:155856
Biological Process	GO:0008628	hormone-mediated apoptotic signaling pathway	IMP	J:91449
Biological Process	GO:0030520	intracellular estrogen receptor signaling pathway	ISO	J:164563
Biological Process	GO:0030520	intracellular estrogen receptor signaling pathway	IBA	J:265628
Biological Process	GO:0030520	intracellular estrogen receptor signaling pathway	IMP	J:126711
Biological Process	GO:0030520	intracellular estrogen receptor signaling pathway	IMP	J:126711
Biological Process	GO:0030518	intracellular steroid hormone receptor signaling pathway	ISO	J:155856
Biological Process	GO:0007611	learning or memory	ISO	J:155856
Biological Process	GO:0060766	negative regulation of androgen receptor signaling pathway	IMP	J:126711
Biological Process	GO:0048521	negative regulation of behavior	ISO	J:155856
Biological Process	GO:0060548	negative regulation of cell death	ISO	J:155856
Biological Process	GO:0008285	negative regulation of cell population proliferation	IGI	J:138676
Biological Process	GO:0050680	negative regulation of epithelial cell proliferation	ISO	J:155856
Biological Process	GO:0050680	negative regulation of epithelial cell proliferation	IMP	J:126711
Biological Process	GO:0050680	negative regulation of epithelial cell proliferation	IMP	J:91449
Biological Process	GO:0050680	negative regulation of epithelial cell proliferation	IMP	J:126711
Biological Process	GO:2000252	negative regulation of feeding behavior	ISO	J:155856
Biological Process	GO:1901215	negative regulation of neuron death	ISO	J:155856
Biological Process	GO:2000378	negative regulation of reactive oxygen species metabolic process	ISO	J:155856
Biological Process	GO:0048662	negative regulation of smooth muscle cell proliferation	ISO	J:155856
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ISO	J:155856
Biological Process	GO:0001764	neuron migration	IMP	J:81418
Biological Process	GO:0001541	ovarian follicle development	IMP	J:51663
Biological Process	GO:0001541	ovarian follicle development	IMP	J:64426
Biological Process	GO:0043065	positive regulation of apoptotic process	ISO	J:155856
Biological Process	GO:0051091	positive regulation of DNA-binding transcription factor activity	ISO	J:164563
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ISO	J:155856
Biological Process	GO:0045742	positive regulation of epidermal growth factor receptor signaling pathway	ISO	J:155856
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	ISO	J:155856
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:155856
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0060740	prostate gland epithelium morphogenesis	IMP	J:91449
Biological Process	GO:0060740	prostate gland epithelium morphogenesis	IMP	J:126711
Biological Process	GO:0042127	regulation of cell population proliferation	IMP	J:49532
Biological Process	GO:0042127	regulation of cell population proliferation	IMP	J:49532
Biological Process	GO:0042127	regulation of cell population proliferation	IMP	J:49532
Biological Process	GO:0006355	regulation of DNA-templated transcription	IEA	J:72247
Biological Process	GO:0043523	regulation of neuron apoptotic process	ISO	J:155856
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0033574	response to testosterone	ISO	J:155856
Biological Process	GO:0060011	Sertoli cell proliferation	ISO	J:155856
Biological Process	GO:0060065	uterus development	IGI	J:64426
Biological Process	GO:0060068	vagina development	IGI	J:64426
Biological Process	GO:0042311	vasodilation	ISO	J:155856