GO Annotations Graph

• Symbol: Itga8
• Name: integrin alpha 8
• ID: MGI:109442

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005178	integrin binding	IBA	J:265628
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Cellular Component	GO:0045177	apical part of cell	IDA	J:61486
Cellular Component	GO:0009986	cell surface	ISO	J:164563
Cellular Component	GO:0032591	dendritic spine membrane	ISO	J:155856
Cellular Component	GO:0005783	endoplasmic reticulum	ISO	J:164563
Cellular Component	GO:0009897	external side of plasma membrane	IBA	J:265628
Cellular Component	GO:0098978	glutamatergic synapse	ISO	J:155856
Cellular Component	GO:0008305	integrin complex	IBA	J:265628
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0043204	perikaryon	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-NUL-4085131
Cellular Component	GO:0014069	postsynaptic density	ISO	J:155856
Cellular Component	GO:0098839	postsynaptic density membrane	ISO	J:155856
Biological Process	GO:0007155	cell adhesion	IEA	J:60000
Biological Process	GO:0007155	cell adhesion	IEA	J:72247
Biological Process	GO:0033627	cell adhesion mediated by integrin	IBA	J:265628
Biological Process	GO:0030154	cell differentiation	IEA	J:60000
Biological Process	GO:0030030	cell projection organization	IMP	J:61486
Biological Process	GO:0098609	cell-cell adhesion	IBA	J:265628
Biological Process	GO:0007160	cell-matrix adhesion	ISO	J:164563
Biological Process	GO:0007160	cell-matrix adhesion	IBA	J:265628
Biological Process	GO:0045184	establishment of protein localization	IMP	J:170886
Biological Process	GO:0030198	extracellular matrix organization	IMP	J:61486
Biological Process	GO:0042472	inner ear morphogenesis	IMP	J:61486
Biological Process	GO:0007229	integrin-mediated signaling pathway	IBA	J:265628
Biological Process	GO:0001822	kidney development	ISO	J:164563
Biological Process	GO:0007613	memory	IMP	J:84858
Biological Process	GO:0001656	metanephros development	IGI	J:122519
Biological Process	GO:0001656	metanephros development	IMP	J:122519
Biological Process	GO:0001656	metanephros development	IGI	J:122519
Biological Process	GO:0007275	multicellular organism development	IEA	J:60000
Biological Process	GO:0007399	nervous system development	IEA	J:60000
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:170886
Biological Process	GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway	IGI	J:122519
Biological Process	GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway	IMP	J:122519
Biological Process	GO:0051145	smooth muscle cell differentiation	IDA	J:170886
Biological Process	GO:0048745	smooth muscle tissue development	IMP	J:170886
Biological Process	GO:0034446	substrate adhesion-dependent cell spreading	ISO	J:164563
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	IMP	J:122519
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	IGI	J:122519