GO Annotations Graph

• Symbol: Ctcf
• Name: CCCTC-binding factor
• ID: MGI:109447

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003682	chromatin binding	IDA	J:204755
Molecular Function	GO:0003682	chromatin binding	IDA	J:188795
Molecular Function	GO:0003682	chromatin binding	IDA	J:202816
Molecular Function	GO:0043035	chromatin insulator sequence binding	ISO	J:164563
Molecular Function	GO:0003677	DNA binding	IDA	J:92776
Molecular Function	GO:0003677	DNA binding	IDA	J:81888
Molecular Function	GO:0003677	DNA binding	IDA	J:91020
Molecular Function	GO:0003677	DNA binding	IDA	J:73834
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	IBA	J:265628
Molecular Function	GO:0003700	DNA-binding transcription factor activity	ISO	J:164563
Molecular Function	GO:0140297	DNA-binding transcription factor binding	ISO	J:155856
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	ISO	J:164563
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:112733
Molecular Function	GO:0005515	protein binding	IPI	J:235308
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO	J:164563
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA	J:265628
Molecular Function	GO:0043565	sequence-specific DNA binding	ISO	J:164563
Molecular Function	GO:0043565	sequence-specific DNA binding	IDA	J:77911
Molecular Function	GO:0000976	transcription cis-regulatory region binding	ISO	J:164563
Molecular Function	GO:0001221	transcription coregulator binding	ISO	J:164563
Cellular Component	GO:0005694	chromosome	IEA	J:60000
Cellular Component	GO:0000775	chromosome, centromeric region	ISO	J:164563
Cellular Component	GO:0000793	condensed chromosome	ISO	J:164563
Cellular Component	GO:0001651	dense fibrillar component	ISO	J:155856
Cellular Component	GO:0001652	granular component	ISO	J:155856
Cellular Component	GO:0001673	male germ cell nucleus	IDA	J:112166
Cellular Component	GO:0005730	nucleolus	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IDA	J:96974
Cellular Component	GO:0005634	nucleus	IDA	J:77911
Biological Process	GO:0140588	chromatin looping	IMP	J:112158
Biological Process	GO:0140588	chromatin looping	ISO	J:164563
Biological Process	GO:0006325	chromatin organization	IEA	J:60000
Biological Process	GO:0007059	chromosome segregation	IEA	J:60000
Biological Process	GO:0006306	DNA methylation	IDA	J:81888
Biological Process	GO:0006306	DNA methylation	IMP	J:202816
Biological Process	GO:0009048	dosage compensation by inactivation of X chromosome	TAS	J:73834
Biological Process	GO:0040029	epigenetic regulation of gene expression	ISO	J:164563
Biological Process	GO:0071514	genomic imprinting	ISO	J:164563
Biological Process	GO:0008285	negative regulation of cell population proliferation	ISO	J:164563
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0010629	negative regulation of gene expression	IMP	J:150910
Biological Process	GO:0044027	negative regulation of gene expression via CpG island methylation	IMP	J:90538
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IMP	J:202816
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:164563
Biological Process	GO:0010628	positive regulation of gene expression	IMP	J:150910
Biological Process	GO:1902895	positive regulation of miRNA transcription	ISO	J:155856
Biological Process	GO:0071459	protein localization to chromosome, centromeric region	ISO	J:164563
Biological Process	GO:0006355	regulation of DNA-templated transcription	IDA	J:91020
Biological Process	GO:0006349	regulation of gene expression by genomic imprinting	IDA	J:91020
Biological Process	GO:0006349	regulation of gene expression by genomic imprinting	IDA	J:81888
Biological Process	GO:0006349	regulation of gene expression by genomic imprinting	IMP	J:90538