Smad1 GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

Smad1
SMAD family member 1
MGI:109452

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0070410	co-SMAD binding	ISO	J:164563
Molecular Function	GO:0017151	DEAD/H-box RNA helicase binding	ISO	J:164563
Molecular Function	GO:0003677	DNA binding	IEA	J:60000
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	ISO	J:164563
Molecular Function	GO:0003700	DNA-binding transcription factor activity	ISO	J:164563
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IDA	J:86912
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IDA	J:107396
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	J:265628
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IDA	J:299317
Molecular Function	GO:0070411	I-SMAD binding	ISO	J:164563
Molecular Function	GO:0070411	I-SMAD binding	IBA	J:265628
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0042802	identical protein binding	IPI	J:183041
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0070878	primary miRNA binding	IDA	J:169047
Molecular Function	GO:0005515	protein binding	IPI	J:240376
Molecular Function	GO:0005515	protein binding	IPI	J:150837
Molecular Function	GO:0005515	protein binding	IPI	J:86912
Molecular Function	GO:0005515	protein binding	IPI	J:178818
Molecular Function	GO:0005515	protein binding	IPI	J:106994
Molecular Function	GO:0005515	protein binding	IPI	J:106994
Molecular Function	GO:0005515	protein binding	IPI	J:93345
Molecular Function	GO:0005515	protein binding	IPI	J:183041
Molecular Function	GO:0005515	protein binding	IPI	J:95124
Molecular Function	GO:0005515	protein binding	IPI	J:170631
Molecular Function	GO:0005515	protein binding	IPI	J:79484
Molecular Function	GO:0005515	protein binding	IPI	J:152281
Molecular Function	GO:0005515	protein binding	IPI	J:211498
Molecular Function	GO:0019901	protein kinase binding	ISO	J:164563
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO	J:164563
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA	J:265628
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	J:142136
Molecular Function	GO:0043565	sequence-specific DNA binding	IDA	J:240259
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IDA	J:172903
Cellular Component	GO:0005737	cytoplasm	IDA	J:151027
Cellular Component	GO:0005737	cytoplasm	IDA	J:145723
Cellular Component	GO:0071144	heteromeric SMAD protein complex	ISO	J:164563
Cellular Component	GO:0071144	heteromeric SMAD protein complex	IBA	J:265628
Cellular Component	GO:0071142	homomeric SMAD protein complex	ISO	J:164563
Cellular Component	GO:0071142	homomeric SMAD protein complex	IPI	J:173440
Cellular Component	GO:0005637	nuclear inner membrane	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IDA	J:151027
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IDA	J:116258
Cellular Component	GO:0005634	nucleus	IDA	J:299317
Cellular Component	GO:0005634	nucleus	IDA	J:217224
Cellular Component	GO:0005634	nucleus	IDA	J:154112
Cellular Component	GO:0005634	nucleus	IDA	J:153961
Cellular Component	GO:0005634	nucleus	IDA	J:145723
Cellular Component	GO:0032991	protein-containing complex	ISO	J:198828
Cellular Component	GO:0005667	transcription regulator complex	IDA	J:86912
Biological Process	GO:0009653	anatomical structure morphogenesis	IBA	J:265628
Biological Process	GO:0030509	BMP signaling pathway	ISO	J:164563
Biological Process	GO:0030509	BMP signaling pathway	IGI	J:196266
Biological Process	GO:0030509	BMP signaling pathway	IGI	J:151027
Biological Process	GO:0030509	BMP signaling pathway	ISO	J:155856
Biological Process	GO:0030509	BMP signaling pathway	IBA	J:265628
Biological Process	GO:0030509	BMP signaling pathway	IDA	J:299317
Biological Process	GO:0030509	BMP signaling pathway	IGI	J:109016
Biological Process	GO:0030509	BMP signaling pathway	IDA	J:217224
Biological Process	GO:0030509	BMP signaling pathway	IMP	J:90769
Biological Process	GO:0030509	BMP signaling pathway	TAS	J:79484
Biological Process	GO:0030509	BMP signaling pathway	IGI	J:147287
Biological Process	GO:0030509	BMP signaling pathway	IGI	J:109016
Biological Process	GO:0030509	BMP signaling pathway	IGI	J:109016
Biological Process	GO:0030509	BMP signaling pathway	IGI	J:147287
Biological Process	GO:0060348	bone development	IGI	J:147287
Biological Process	GO:0060348	bone development	IGI	J:147287
Biological Process	GO:0060038	cardiac muscle cell proliferation	IMP	J:185712
Biological Process	GO:0060038	cardiac muscle cell proliferation	IGI	J:185712
Biological Process	GO:0051216	cartilage development	IGI	J:147287
Biological Process	GO:0051216	cartilage development	IGI	J:147287
Biological Process	GO:0030154	cell differentiation	IBA	J:265628
Biological Process	GO:0008283	cell population proliferation	IMP	J:99098
Biological Process	GO:0008283	cell population proliferation	IMP	J:99098
Biological Process	GO:0008283	cell population proliferation	IMP	J:99098
Biological Process	GO:0008283	cell population proliferation	IMP	J:99098
Biological Process	GO:0008283	cell population proliferation	IMP	J:99098
Biological Process	GO:0008283	cell population proliferation	IMP	J:99098
Biological Process	GO:0071773	cellular response to BMP stimulus	IGI	J:196266
Biological Process	GO:0071407	cellular response to organic cyclic compound	IDA	J:145723
Biological Process	GO:0006351	DNA-templated transcription	ISO	J:164563
Biological Process	GO:0007276	gamete generation	IMP	J:90769
Biological Process	GO:0030902	hindbrain development	IMP	J:99098
Biological Process	GO:0042592	homeostatic process	IMP	J:90769
Biological Process	GO:0006954	inflammatory response	IEP	J:116258
Biological Process	GO:0000165	MAPK cascade	ISO	J:155856
Biological Process	GO:0000165	MAPK cascade	IMP	J:90769
Biological Process	GO:0001710	mesodermal cell fate commitment	IGI	J:111703
Biological Process	GO:0030901	midbrain development	IMP	J:99098
Biological Process	GO:0008285	negative regulation of cell population proliferation	IMP	J:99098
Biological Process	GO:0051148	negative regulation of muscle cell differentiation	IDA	J:299317
Biological Process	GO:0001649	osteoblast differentiation	ISO	J:164563
Biological Process	GO:0001649	osteoblast differentiation	IDA	J:299402
Biological Process	GO:0002051	osteoblast fate commitment	IGI	J:93345
Biological Process	GO:0061036	positive regulation of cartilage development	IDA	J:149852
Biological Process	GO:0045597	positive regulation of cell differentiation	ISO	J:155856
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:164563
Biological Process	GO:0010628	positive regulation of gene expression	IMP	J:138571
Biological Process	GO:1902895	positive regulation of miRNA transcription	IMP	J:169047
Biological Process	GO:0045669	positive regulation of osteoblast differentiation	IGI	J:93345
Biological Process	GO:1903672	positive regulation of sprouting angiogenesis	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:107396
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:211498
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:144043
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:96487
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:149852
Biological Process	GO:1901522	positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus	IGI	J:196266
Biological Process	GO:0006468	protein phosphorylation	IDA	J:138769
Biological Process	GO:0006355	regulation of DNA-templated transcription	IEA	J:72247
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IDA	J:80201
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IDA	J:86912
Biological Process	GO:0009410	response to xenobiotic stimulus	ISO	J:155856
Biological Process	GO:0007183	SMAD protein complex assembly	ISO	J:164563
Biological Process	GO:0060395	SMAD protein signal transduction	ISO	J:164563
Biological Process	GO:0060395	SMAD protein signal transduction	IGI	J:151027
Biological Process	GO:0060395	SMAD protein signal transduction	IBA	J:265628
Biological Process	GO:0006366	transcription by RNA polymerase II	IDA	J:144043
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	ISO	J:164563
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	IBA	J:265628
Biological Process	GO:0001657	ureteric bud development	IEP	J:95433

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24