GO Annotations Graph

• Symbol: Commd1
• Name: COMM domain containing 1
• ID: MGI:109474

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005507	copper ion binding	ISO	J:164563
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0050750	low-density lipoprotein particle receptor binding	ISO	J:236595
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0070300	phosphatidic acid binding	ISO	J:164563
Molecular Function	GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding	ISO	J:164563
Molecular Function	GO:0043325	phosphatidylinositol-3,4-bisphosphate binding	ISO	J:164563
Molecular Function	GO:0080025	phosphatidylinositol-3,5-bisphosphate binding	ISO	J:164563
Molecular Function	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:122208
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:164563
Molecular Function	GO:0019871	sodium channel inhibitor activity	ISO	J:73065
Cellular Component	GO:0031462	Cul2-RING ubiquitin ligase complex	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0031410	cytoplasmic vesicle	IEA	J:60000
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005769	early endosome	ISO	J:164563
Cellular Component	GO:0005768	endosome	IBA	J:265628
Cellular Component	GO:0005768	endosome	IDA	J:236595
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0055037	recycling endosome	ISO	J:164563
Biological Process	GO:0042632	cholesterol homeostasis	ISO	J:236595
Biological Process	GO:0042632	cholesterol homeostasis	IMP	J:236595
Biological Process	GO:0055070	copper ion homeostasis	ISO	J:164563
Biological Process	GO:0055070	copper ion homeostasis	IBA	J:265628
Biological Process	GO:0055070	copper ion homeostasis	ISO	J:236595
Biological Process	GO:0006893	Golgi to plasma membrane transport	ISO	J:164563
Biological Process	GO:0006878	intracellular copper ion homeostasis	ISO	J:74624
Biological Process	GO:0034383	low-density lipoprotein particle clearance	IMP	J:236595
Biological Process	GO:1902072	negative regulation of hypoxia-inducible factor-1alpha signaling pathway	IMP	J:122208
Biological Process	GO:0032088	negative regulation of NF-kappaB transcription factor activity	ISO	J:164563
Biological Process	GO:0032088	negative regulation of NF-kappaB transcription factor activity	ISO	J:115897
Biological Process	GO:2000009	negative regulation of protein localization to cell surface	ISO	J:164563
Biological Process	GO:2000009	negative regulation of protein localization to cell surface	IBA	J:265628
Biological Process	GO:1902306	negative regulation of sodium ion transmembrane transport	ISO	J:164563
Biological Process	GO:1902306	negative regulation of sodium ion transmembrane transport	IBA	J:265628
Biological Process	GO:0006289	nucleotide-excision repair	ISO	J:164563
Biological Process	GO:0048227	plasma membrane to endosome transport	ISO	J:164563
Biological Process	GO:1904109	positive regulation of cholesterol import	IMP	J:236595
Biological Process	GO:1905751	positive regulation of endosome to plasma membrane protein transport	IMP	J:236595
Biological Process	GO:2000010	positive regulation of protein localization to cell surface	IMP	J:236595
Biological Process	GO:0031398	positive regulation of protein ubiquitination	ISO	J:164563
Biological Process	GO:0031398	positive regulation of protein ubiquitination	IBA	J:265628
Biological Process	GO:0031648	protein destabilization	IMP	J:122208
Biological Process	GO:0034394	protein localization to cell surface	IMP	J:236595
Biological Process	GO:0015031	protein transport	IEA	J:60000
Biological Process	GO:0097006	regulation of plasma lipoprotein particle levels	IMP	J:236595
Biological Process	GO:0032434	regulation of proteasomal ubiquitin-dependent protein catabolic process	ISO	J:164563
Biological Process	GO:0032434	regulation of proteasomal ubiquitin-dependent protein catabolic process	IBA	J:265628