GO Annotations Graph

• Symbol: Prdx2
• Name: peroxiredoxin 2
• ID: MGI:109486

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0016209	antioxidant activity	ISO	J:164563
Molecular Function	GO:0016491	oxidoreductase activity	IEA	J:72247
Molecular Function	GO:0016491	oxidoreductase activity	IEA	J:60000
Molecular Function	GO:0004601	peroxidase activity	TAS	J:39372
Molecular Function	GO:0051920	peroxiredoxin activity	IEA	J:72247
Molecular Function	GO:0005515	protein binding	IPI	J:120297
Molecular Function	GO:0008430	selenium binding	TAS	J:50815
Molecular Function	GO:0008379	thioredoxin peroxidase activity	ISO	J:164563
Molecular Function	GO:0008379	thioredoxin peroxidase activity	IBA	J:265628
Molecular Function	GO:0008379	thioredoxin peroxidase activity	ISS	J:39372
Molecular Function	GO:0008379	thioredoxin peroxidase activity	TAS	J:49541
Molecular Function	GO:0140824	thioredoxin-dependent peroxiredoxin activity	IEA	J:72245
Cellular Component	GO:0005737	cytoplasm	IEA	J:60000
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-8868589
Cellular Component	GO:0005829	cytosol	IBA	J:265628
Cellular Component	GO:0005739	mitochondrion	HDA	J:151002
Cellular Component	GO:0043209	myelin sheath	HDA	J:145263
Biological Process	GO:0045454	cell redox homeostasis	IBA	J:265628
Biological Process	GO:0034599	cellular response to oxidative stress	ISO	J:164563
Biological Process	GO:0033554	cellular response to stress	IBA	J:265628
Biological Process	GO:0002357	defense response to tumor cell	ISO	J:164563
Biological Process	GO:0097191	extrinsic apoptotic signaling pathway	IMP	J:91748
Biological Process	GO:0097191	extrinsic apoptotic signaling pathway	IMP	J:91748
Biological Process	GO:0042744	hydrogen peroxide catabolic process	IBA	J:265628
Biological Process	GO:0042744	hydrogen peroxide catabolic process	IMP	J:98582
Biological Process	GO:0042743	hydrogen peroxide metabolic process	IMP	J:125361
Biological Process	GO:0042743	hydrogen peroxide metabolic process	IMP	J:91748
Biological Process	GO:0045321	leukocyte activation	IBA	J:265628
Biological Process	GO:2001237	negative regulation of extrinsic apoptotic signaling pathway	IMP	J:91748
Biological Process	GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	IDA	J:39372
Biological Process	GO:0031665	negative regulation of lipopolysaccharide-mediated signaling pathway	IMP	J:125361
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	ISO	J:155856
Biological Process	GO:0032088	negative regulation of NF-kappaB transcription factor activity	IMP	J:125361
Biological Process	GO:0045581	negative regulation of T cell differentiation	IMP	J:136791
Biological Process	GO:0030194	positive regulation of blood coagulation	IMP	J:166919
Biological Process	GO:0043410	positive regulation of MAPK cascade	IMP	J:125361
Biological Process	GO:0042981	regulation of apoptotic process	ISO	J:164563
Biological Process	GO:0010310	regulation of hydrogen peroxide metabolic process	IMP	J:125361
Biological Process	GO:0019430	removal of superoxide radicals	IMP	J:166919
Biological Process	GO:0019430	removal of superoxide radicals	ISO	J:164563
Biological Process	GO:0019430	removal of superoxide radicals	IBA	J:265628
Biological Process	GO:0002536	respiratory burst involved in inflammatory response	IMP	J:125361
Biological Process	GO:0032496	response to lipopolysaccharide	IMP	J:125361
Biological Process	GO:0006979	response to oxidative stress	ISO	J:164563
Biological Process	GO:0006979	response to oxidative stress	ISO	J:155856
Biological Process	GO:0006979	response to oxidative stress	IBA	J:265628
Biological Process	GO:0006979	response to oxidative stress	TAS	J:39372
Biological Process	GO:0043029	T cell homeostasis	IMP	J:91748
Biological Process	GO:0042098	T cell proliferation	IMP	J:91748
Biological Process	GO:0048538	thymus development	IMP	J:91748