GO Annotations Graph

• Symbol: Ptch2
• Name: patched 2
• ID: MGI:1095405

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0097108	hedgehog family protein binding	ISO	J:164563
Molecular Function	GO:0097108	hedgehog family protein binding	IBA	J:265628
Molecular Function	GO:0008158	hedgehog receptor activity	IBA	J:265628
Molecular Function	GO:0005119	smoothened binding	ISO	J:164563
Molecular Function	GO:0005119	smoothened binding	IBA	J:265628
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005886	plasma membrane	IBA	J:265628
Biological Process	GO:0001709	cell fate determination	IGI	J:210838
Biological Process	GO:0009957	epidermal cell fate specification	IGI	J:210838
Biological Process	GO:0008544	epidermis development	IMP	J:112169
Biological Process	GO:0042633	hair cycle	IMP	J:112169
Biological Process	GO:0045879	negative regulation of smoothened signaling pathway	IBA	J:265628
Biological Process	GO:0045606	positive regulation of epidermal cell differentiation	IGI	J:210838
Biological Process	GO:0001558	regulation of cell growth	ISO	J:164563
Biological Process	GO:0043588	skin development	IMP	J:112169