GO Annotations Graph

• Symbol: Bmpr2
• Name: bone morphogenetic protein receptor type 2
• ID: MGI:1095407

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	IEA	J:72247
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0036122	BMP binding	ISO	J:164563
Molecular Function	GO:0036122	BMP binding	IDA	J:299317
Molecular Function	GO:0098821	BMP receptor activity	IMP	J:229306
Molecular Function	GO:0098821	BMP receptor activity	ISO	J:164563
Molecular Function	GO:0098821	BMP receptor activity	IDA	J:299317
Molecular Function	GO:0045296	cadherin binding	ISO	J:164563
Molecular Function	GO:0019838	growth factor binding	ISO	J:155856
Molecular Function	GO:0019209	kinase activator activity	ISO	J:164563
Molecular Function	GO:0016301	kinase activity	ISO	J:164563
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:200390
Molecular Function	GO:0005515	protein binding	IPI	J:299315
Molecular Function	GO:0004672	protein kinase activity	IEA	J:72247
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IDA	J:299317
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IMP	J:299322
Molecular Function	GO:1990782	protein tyrosine kinase binding	ISO	J:164563
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Molecular Function	GO:0005024	transforming growth factor beta receptor activity	IBA	J:265628
Molecular Function	GO:0004675	transmembrane receptor protein serine/threonine kinase activity	IEA	J:72247
Molecular Function	GO:0004675	transmembrane receptor protein serine/threonine kinase activity	IEA	J:72245
Cellular Component	GO:0005912	adherens junction	ISO	J:164563
Cellular Component	GO:0016324	apical plasma membrane	ISO	J:155856
Cellular Component	GO:0030424	axon	IDA	J:123318
Cellular Component	GO:0009925	basal plasma membrane	ISO	J:155856
Cellular Component	GO:0005901	caveola	ISO	J:155856
Cellular Component	GO:0005901	caveola	ISO	J:164563
Cellular Component	GO:0044297	cell body	IDA	J:123318
Cellular Component	GO:0009986	cell surface	ISO	J:164563
Cellular Component	GO:0009986	cell surface	IDA	J:77444
Cellular Component	GO:0005905	clathrin-coated pit	IDA	J:299315
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0030425	dendrite	ISO	J:155856
Cellular Component	GO:0030425	dendrite	IDA	J:123318
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0043025	neuronal cell body	ISO	J:155856
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IBA	J:265628
Cellular Component	GO:0005886	plasma membrane	IDA	J:299318
Cellular Component	GO:0005886	plasma membrane	IDA	J:299317
Cellular Component	GO:0005886	plasma membrane	IDA	J:201437
Cellular Component	GO:0005886	plasma membrane	IDA	J:201437
Cellular Component	GO:0014069	postsynaptic density	IDA	J:187362
Cellular Component	GO:0043235	receptor complex	IBA	J:265628
Biological Process	GO:0009952	anterior/posterior pattern specification	IGI	J:95124
Biological Process	GO:0009952	anterior/posterior pattern specification	IMP	J:61931
Biological Process	GO:0003176	aortic valve development	IMP	J:80024
Biological Process	GO:0060840	artery development	IMP	J:157791
Biological Process	GO:0060413	atrial septum morphogenesis	IMP	J:150767
Biological Process	GO:0001568	blood vessel development	IBA	J:265628
Biological Process	GO:0001974	blood vessel remodeling	IMP	J:157791
Biological Process	GO:0030509	BMP signaling pathway	IMP	J:229306
Biological Process	GO:0030509	BMP signaling pathway	IMP	J:137457
Biological Process	GO:0030509	BMP signaling pathway	ISO	J:164563
Biological Process	GO:0030509	BMP signaling pathway	IBA	J:265628
Biological Process	GO:0030509	BMP signaling pathway	IDA	J:299317
Biological Process	GO:0030509	BMP signaling pathway	IMP	J:123381
Biological Process	GO:0030509	BMP signaling pathway	ISO	J:123381
Biological Process	GO:0071773	cellular response to BMP stimulus	ISO	J:164563
Biological Process	GO:0071363	cellular response to growth factor stimulus	IBA	J:265628
Biological Process	GO:0002063	chondrocyte development	ISO	J:164563
Biological Process	GO:0003197	endocardial cushion development	IMP	J:80024
Biological Process	GO:0072577	endothelial cell apoptotic process	ISO	J:164563
Biological Process	GO:0001935	endothelial cell proliferation	ISO	J:164563
Biological Process	GO:0060173	limb development	IGI	J:198828
Biological Process	GO:0048286	lung alveolus development	IMP	J:137457
Biological Process	GO:0001946	lymphangiogenesis	IMP	J:157791
Biological Process	GO:0060836	lymphatic endothelial cell differentiation	IMP	J:157791
Biological Process	GO:0001893	maternal placenta development	IMP	J:201437
Biological Process	GO:0001707	mesoderm formation	IMP	J:61931
Biological Process	GO:0003183	mitral valve morphogenesis	IMP	J:150767
Biological Process	GO:0030308	negative regulation of cell growth	ISO	J:164563
Biological Process	GO:0003252	negative regulation of cell proliferation involved in heart valve morphogenesis	IMP	J:150767
Biological Process	GO:1902731	negative regulation of chondrocyte proliferation	ISO	J:164563
Biological Process	GO:2000279	negative regulation of DNA biosynthetic process	ISO	J:164563
Biological Process	GO:0051148	negative regulation of muscle cell differentiation	IDA	J:299317
Biological Process	GO:0048662	negative regulation of smooth muscle cell proliferation	ISO	J:164563
Biological Process	GO:0003085	negative regulation of systemic arterial blood pressure	ISO	J:164563
Biological Process	GO:0045906	negative regulation of vasoconstriction	IMP	J:137457
Biological Process	GO:0001649	osteoblast differentiation	ISO	J:164563
Biological Process	GO:0001649	osteoblast differentiation	IDA	J:299402
Biological Process	GO:0003151	outflow tract morphogenesis	IMP	J:150767
Biological Process	GO:0003148	outflow tract septum morphogenesis	IMP	J:80024
Biological Process	GO:0061626	pharyngeal arch artery morphogenesis	IMP	J:80024
Biological Process	GO:0016310	phosphorylation	IEA	J:60000
Biological Process	GO:0048842	positive regulation of axon extension involved in axon guidance	IMP	J:206541
Biological Process	GO:0030513	positive regulation of BMP signaling pathway	ISO	J:164563
Biological Process	GO:0030501	positive regulation of bone mineralization	ISO	J:164563
Biological Process	GO:0010595	positive regulation of endothelial cell migration	ISO	J:164563
Biological Process	GO:0001938	positive regulation of endothelial cell proliferation	ISO	J:164563
Biological Process	GO:0010634	positive regulation of epithelial cell migration	ISO	J:164563
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:164563
Biological Process	GO:0045778	positive regulation of ossification	IMP	J:80024
Biological Process	GO:0045669	positive regulation of osteoblast differentiation	ISO	J:164563
Biological Process	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	ISO	J:164563
Biological Process	GO:0001934	positive regulation of protein phosphorylation	ISO	J:123381
Biological Process	GO:0060391	positive regulation of SMAD protein signal transduction	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:80024
Biological Process	GO:0006468	protein phosphorylation	IBA	J:265628
Biological Process	GO:0003177	pulmonary valve development	IMP	J:80024
Biological Process	GO:0042127	regulation of cell population proliferation	ISO	J:164563
Biological Process	GO:0014916	regulation of lung blood pressure	ISO	J:164563
Biological Process	GO:0014916	regulation of lung blood pressure	IMP	J:137457
Biological Process	GO:0061298	retina vasculature development in camera-type eye	IMP	J:157791
Biological Process	GO:1905314	semi-lunar valve development	IMP	J:80024
Biological Process	GO:1905314	semi-lunar valve development	IMP	J:150767
Biological Process	GO:0007178	transmembrane receptor protein serine/threonine kinase signaling pathway	ISO	J:164563
Biological Process	GO:0003186	tricuspid valve morphogenesis	IMP	J:150767
Biological Process	GO:0060841	venous blood vessel development	IMP	J:157791
Biological Process	GO:0060412	ventricular septum morphogenesis	IMP	J:80024
Biological Process	GO:0060412	ventricular septum morphogenesis	IMP	J:150767