Kdm6a GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

Kdm6a
lysine (K)-specific demethylase 6A
MGI:1095419

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0031490	chromatin DNA binding	IBA	J:265628
Molecular Function	GO:0031490	chromatin DNA binding	IDA	J:200020
Molecular Function	GO:0051213	dioxygenase activity	IEA	J:60000
Molecular Function	GO:0071558	histone H3K27me2/H3K27me3 demethylase activity	IBA	J:265628
Molecular Function	GO:0071558	histone H3K27me2/H3K27me3 demethylase activity	IDA	J:190157
Molecular Function	GO:0042802	identical protein binding	IDA	J:201868
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0016491	oxidoreductase activity	IEA	J:60000
Molecular Function	GO:1990841	promoter-specific chromatin binding	ISO	J:155856
Molecular Function	GO:0005515	protein binding	IPI	J:195534
Molecular Function	GO:0005515	protein binding	IPI	J:200376
Molecular Function	GO:0005515	protein binding	IPI	J:166998
Molecular Function	GO:0005515	protein binding	IPI	J:201868
Molecular Function	GO:0005515	protein binding	IPI	J:201868
Molecular Function	GO:0005515	protein binding	IPI	J:190157
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA	J:265628
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	J:190157
Cellular Component	GO:0035097	histone methyltransferase complex	IDA	J:201868
Cellular Component	GO:0035097	histone methyltransferase complex	ISO	J:123598
Cellular Component	GO:0044666	MLL3/4 complex	ISO	J:164563
Cellular Component	GO:0044666	MLL3/4 complex	IBA	J:265628
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-5617960
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-5617990
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-5619411
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-5619424
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-5619428
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-5619430
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-5619434
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-5619436
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-5619437
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-5619440
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-5619441
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-5621004
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-5621012
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-5693628
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-6810138
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-6810150
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-6810169
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-6810170
Cellular Component	GO:0005634	nucleus	ISO	J:123598
Cellular Component	GO:0005634	nucleus	IDA	J:190157
Biological Process	GO:0071305	cellular response to vitamin D	ISO	J:155856
Biological Process	GO:0006325	chromatin organization	IEA	J:60000
Biological Process	GO:0006338	chromatin remodeling	IMP	J:166998
Biological Process	GO:0072359	circulatory system development	IMP	J:201868
Biological Process	GO:0072359	circulatory system development	IMP	J:201868
Biological Process	GO:0048568	embryonic organ development	IMP	J:201868
Biological Process	GO:0048568	embryonic organ development	IMP	J:201868
Biological Process	GO:0007507	heart development	IBA	J:265628
Biological Process	GO:0007507	heart development	IMP	J:190157
Biological Process	GO:0003007	heart morphogenesis	IMP	J:201868
Biological Process	GO:0003007	heart morphogenesis	IMP	J:201868
Biological Process	GO:0071557	histone H3-K27 demethylation	ISO	J:155856
Biological Process	GO:0071557	histone H3-K27 demethylation	IBA	J:265628
Biological Process	GO:0001701	in utero embryonic development	IMP	J:190157
Biological Process	GO:0001701	in utero embryonic development	IMP	J:201868
Biological Process	GO:0001701	in utero embryonic development	IMP	J:201868
Biological Process	GO:0048333	mesodermal cell differentiation	IMP	J:190157
Biological Process	GO:0048333	mesodermal cell differentiation	IMP	J:190157
Biological Process	GO:0035264	multicellular organism growth	IMP	J:201868
Biological Process	GO:0035264	multicellular organism growth	IMP	J:201868
Biological Process	GO:1903298	negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway	ISO	J:155856
Biological Process	GO:0001843	neural tube closure	IMP	J:190157
Biological Process	GO:0021915	neural tube development	IMP	J:201868
Biological Process	GO:0021915	neural tube development	IMP	J:201868
Biological Process	GO:0048570	notochord morphogenesis	IMP	J:190157
Biological Process	GO:0045793	positive regulation of cell size	ISO	J:155856
Biological Process	GO:0010628	positive regulation of gene expression	IMP	J:200020
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:155856
Biological Process	GO:0010468	regulation of gene expression	IBA	J:265628
Biological Process	GO:0010468	regulation of gene expression	IMP	J:201868
Biological Process	GO:0003016	respiratory system process	IMP	J:190157
Biological Process	GO:0032525	somite rostral/caudal axis specification	IMP	J:190157

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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