GO Annotations Graph

• Symbol: Nck1
• Name: non-catalytic region of tyrosine kinase adaptor protein 1
• ID: MGI:109601

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0046875	ephrin receptor binding	IBA	J:265628
Molecular Function	GO:0046875	ephrin receptor binding	IPI	J:152203
Molecular Function	GO:0071074	eukaryotic initiation factor eIF2 binding	ISO	J:164563
Molecular Function	GO:0071074	eukaryotic initiation factor eIF2 binding	ISO	J:155856
Molecular Function	GO:0071074	eukaryotic initiation factor eIF2 binding	IPI	J:217290
Molecular Function	GO:0140693	molecular condensate scaffold activity	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:164892
Molecular Function	GO:0005515	protein binding	IPI	J:111029
Molecular Function	GO:0005515	protein binding	IPI	J:91138
Molecular Function	GO:0005515	protein binding	IPI	J:86235
Molecular Function	GO:0019904	protein domain specific binding	IPI	J:57558
Molecular Function	GO:0004860	protein kinase inhibitor activity	ISO	J:164563
Molecular Function	GO:0030674	protein-macromolecule adaptor activity	ISO	J:164563
Molecular Function	GO:0030971	receptor tyrosine kinase binding	ISO	J:164563
Molecular Function	GO:0005102	signaling receptor binding	ISO	J:164563
Cellular Component	GO:0005911	cell-cell junction	IDA	J:205441
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005783	endoplasmic reticulum	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IEA	J:60000
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0000164	protein phosphatase type 1 complex	ISO	J:164563
Cellular Component	GO:0005840	ribosome	ISO	J:164563
Cellular Component	GO:0012506	vesicle membrane	IDA	J:79320
Biological Process	GO:0007015	actin filament organization	IMP	J:83596
Biological Process	GO:0016477	cell migration	IMP	J:83596
Biological Process	GO:0048013	ephrin receptor signaling pathway	IMP	J:152203
Biological Process	GO:0030032	lamellipodium assembly	IMP	J:83956
Biological Process	GO:0060548	negative regulation of cell death	ISO	J:164563
Biological Process	GO:1903912	negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation	IGI	J:217282
Biological Process	GO:1903912	negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation	IGI	J:217285
Biological Process	GO:1903912	negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation	ISO	J:164563
Biological Process	GO:1903912	negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation	IBA	J:265628
Biological Process	GO:0046627	negative regulation of insulin receptor signaling pathway	ISO	J:164563
Biological Process	GO:0033137	negative regulation of peptidyl-serine phosphorylation	ISO	J:164563
Biological Process	GO:1903898	negative regulation of PERK-mediated unfolded protein response	ISO	J:164563
Biological Process	GO:1903898	negative regulation of PERK-mediated unfolded protein response	IGI	J:217285
Biological Process	GO:1903898	negative regulation of PERK-mediated unfolded protein response	IBA	J:265628
Biological Process	GO:1990441	negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress	ISO	J:164563
Biological Process	GO:1990441	negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress	IGI	J:217282
Biological Process	GO:0070262	peptidyl-serine dephosphorylation	ISO	J:164563
Biological Process	GO:0030838	positive regulation of actin filament polymerization	ISO	J:164563
Biological Process	GO:0030838	positive regulation of actin filament polymerization	IGI	J:128987
Biological Process	GO:0030838	positive regulation of actin filament polymerization	IGI	J:128987
Biological Process	GO:0030838	positive regulation of actin filament polymerization	IGI	J:128987
Biological Process	GO:1903676	positive regulation of cap-dependent translational initiation	ISO	J:164563
Biological Process	GO:1903679	positive regulation of cap-independent translational initiation	ISO	J:164563
Biological Process	GO:1902237	positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	IGI	J:217282
Biological Process	GO:1902237	positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	ISO	J:164563
Biological Process	GO:1902237	positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	IBA	J:265628
Biological Process	GO:0010976	positive regulation of neuron projection development	IMP	J:152203
Biological Process	GO:0042102	positive regulation of T cell proliferation	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0036493	positive regulation of translation in response to endoplasmic reticulum stress	IGI	J:217285
Biological Process	GO:0036493	positive regulation of translation in response to endoplasmic reticulum stress	ISO	J:164563
Biological Process	GO:0036493	positive regulation of translation in response to endoplasmic reticulum stress	IBA	J:265628
Biological Process	GO:0030334	regulation of cell migration	IGI	J:152203
Biological Process	GO:0006417	regulation of translation	IEA	J:60000
Biological Process	GO:0051707	response to other organism	IMP	J:190527
Biological Process	GO:0006930	substrate-dependent cell migration, cell extension	IGI	J:149136
Biological Process	GO:0006930	substrate-dependent cell migration, cell extension	IGI	J:149136
Biological Process	GO:0042110	T cell activation	ISO	J:164563