Nck1 GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

Nck1
non-catalytic region of tyrosine kinase adaptor protein 1
MGI:109601

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0046875	ephrin receptor binding	IBA	J:265628
Molecular Function	GO:0046875	ephrin receptor binding	IPI	J:152203
Molecular Function	GO:0071074	eukaryotic initiation factor eIF2 binding	ISO	J:164563
Molecular Function	GO:0071074	eukaryotic initiation factor eIF2 binding	ISO	J:155856
Molecular Function	GO:0071074	eukaryotic initiation factor eIF2 binding	IPI	J:217290
Molecular Function	GO:0140693	molecular condensate scaffold activity	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:164892
Molecular Function	GO:0005515	protein binding	IPI	J:111029
Molecular Function	GO:0005515	protein binding	IPI	J:91138
Molecular Function	GO:0005515	protein binding	IPI	J:86235
Molecular Function	GO:0019904	protein domain specific binding	IPI	J:57558
Molecular Function	GO:0004860	protein kinase inhibitor activity	ISO	J:164563
Molecular Function	GO:0030674	protein-macromolecule adaptor activity	ISO	J:164563
Molecular Function	GO:0030971	receptor tyrosine kinase binding	ISO	J:164563
Molecular Function	GO:0005102	signaling receptor binding	ISO	J:164563
Cellular Component	GO:0005911	cell-cell junction	IDA	J:205441
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005783	endoplasmic reticulum	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IEA	J:60000
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0000164	protein phosphatase type 1 complex	ISO	J:164563
Cellular Component	GO:0005840	ribosome	ISO	J:164563
Cellular Component	GO:0012506	vesicle membrane	IDA	J:79320
Biological Process	GO:0007015	actin filament organization	IMP	J:83596
Biological Process	GO:0016477	cell migration	IMP	J:83596
Biological Process	GO:0048013	ephrin receptor signaling pathway	IMP	J:152203
Biological Process	GO:0030032	lamellipodium assembly	IMP	J:83956
Biological Process	GO:0060548	negative regulation of cell death	ISO	J:164563
Biological Process	GO:1903912	negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation	IGI	J:217282
Biological Process	GO:1903912	negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation	IGI	J:217285
Biological Process	GO:1903912	negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation	ISO	J:164563
Biological Process	GO:1903912	negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation	IBA	J:265628
Biological Process	GO:0046627	negative regulation of insulin receptor signaling pathway	ISO	J:164563
Biological Process	GO:0033137	negative regulation of peptidyl-serine phosphorylation	ISO	J:164563
Biological Process	GO:1903898	negative regulation of PERK-mediated unfolded protein response	ISO	J:164563
Biological Process	GO:1903898	negative regulation of PERK-mediated unfolded protein response	IGI	J:217285
Biological Process	GO:1903898	negative regulation of PERK-mediated unfolded protein response	IBA	J:265628
Biological Process	GO:1990441	negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress	ISO	J:164563
Biological Process	GO:1990441	negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress	IGI	J:217282
Biological Process	GO:0070262	peptidyl-serine dephosphorylation	ISO	J:164563
Biological Process	GO:0030838	positive regulation of actin filament polymerization	ISO	J:164563
Biological Process	GO:0030838	positive regulation of actin filament polymerization	IGI	J:128987
Biological Process	GO:0030838	positive regulation of actin filament polymerization	IGI	J:128987
Biological Process	GO:0030838	positive regulation of actin filament polymerization	IGI	J:128987
Biological Process	GO:1903676	positive regulation of cap-dependent translational initiation	ISO	J:164563
Biological Process	GO:1903679	positive regulation of cap-independent translational initiation	ISO	J:164563
Biological Process	GO:1902237	positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	IGI	J:217282
Biological Process	GO:1902237	positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	ISO	J:164563
Biological Process	GO:1902237	positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	IBA	J:265628
Biological Process	GO:0010976	positive regulation of neuron projection development	IMP	J:152203
Biological Process	GO:0042102	positive regulation of T cell proliferation	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0036493	positive regulation of translation in response to endoplasmic reticulum stress	IGI	J:217285
Biological Process	GO:0036493	positive regulation of translation in response to endoplasmic reticulum stress	ISO	J:164563
Biological Process	GO:0036493	positive regulation of translation in response to endoplasmic reticulum stress	IBA	J:265628
Biological Process	GO:0030334	regulation of cell migration	IGI	J:152203
Biological Process	GO:0006417	regulation of translation	IEA	J:60000
Biological Process	GO:0051707	response to other organism	IMP	J:190527
Biological Process	GO:0006930	substrate-dependent cell migration, cell extension	IGI	J:149136
Biological Process	GO:0006930	substrate-dependent cell migration, cell extension	IGI	J:149136
Biological Process	GO:0042110	T cell activation	ISO	J:164563

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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