GO Annotations Graph

• Symbol: Srgap2
• Name: SLIT-ROBO Rho GTPase activating protein 2
• ID: MGI:109605

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005096	GTPase activator activity	ISO	J:164563
Molecular Function	GO:0005096	GTPase activator activity	IDA	J:319958
Molecular Function	GO:0005096	GTPase activator activity	IDA	J:153892
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:38792
Molecular Function	GO:0046982	protein heterodimerization activity	ISO	J:164563
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:164563
Molecular Function	GO:0042803	protein homodimerization activity	IDA	J:153892
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:164563
Molecular Function	GO:0031267	small GTPase binding	ISO	J:164563
Molecular Function	GO:0031267	small GTPase binding	IDA	J:153892
Cellular Component	GO:0042995	cell projection	IEA	J:60000
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0031410	cytoplasmic vesicle	IEA	J:60000
Cellular Component	GO:0005829	cytosol	IDA	J:184956
Cellular Component	GO:0043197	dendritic spine	IDA	J:239710
Cellular Component	GO:0044327	dendritic spine head	ISO	J:164563
Cellular Component	GO:0030027	lamellipodium	ISO	J:164563
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005743	mitochondrial inner membrane	HDA	J:100953
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0045335	phagocytic vesicle	IDA	J:184956
Cellular Component	GO:0005886	plasma membrane	IDA	J:153892
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0014069	postsynaptic density	IDA	J:185134
Cellular Component	GO:0045211	postsynaptic membrane	IDA	J:185134
Cellular Component	GO:0045202	synapse	IEA	J:60000
Biological Process	GO:0060996	dendritic spine development	IMP	J:185134
Biological Process	GO:1904861	excitatory synapse assembly	IMP	J:239710
Biological Process	GO:0021816	extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration	IMP	J:153892
Biological Process	GO:0046847	filopodium assembly	IDA	J:153892
Biological Process	GO:1904862	inhibitory synapse assembly	IMP	J:239710
Biological Process	GO:0030336	negative regulation of cell migration	IBA	J:265628
Biological Process	GO:0007399	nervous system development	IEA	J:60000
Biological Process	GO:0048812	neuron projection morphogenesis	IMP	J:153892
Biological Process	GO:0043547	positive regulation of GTPase activity	IDA	J:153892
Biological Process	GO:0030334	regulation of cell migration	IDA	J:319958
Biological Process	GO:0007165	signal transduction	IEA	J:72247