Hcn1 GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

Hcn1
hyperpolarization activated cyclic nucleotide gated potassium channel 1
MGI:1096392

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0030552	cAMP binding	ISO	J:164563
Molecular Function	GO:0030552	cAMP binding	IDA	J:202583
Molecular Function	GO:0042802	identical protein binding	IPI	J:202583
Molecular Function	GO:0042802	identical protein binding	ISO	J:155856
Molecular Function	GO:0005222	intracellular cAMP-activated cation channel activity	IMP	J:202583
Molecular Function	GO:0005222	intracellular cAMP-activated cation channel activity	IDA	J:302698
Molecular Function	GO:0140232	intracellular cAMP-activated cation channel activity involved in regulation of presynaptic membrane potential	IDA	J:172304
Molecular Function	GO:0140232	intracellular cAMP-activated cation channel activity involved in regulation of presynaptic membrane potential	EXP	J:172304
Molecular Function	GO:0140232	intracellular cAMP-activated cation channel activity involved in regulation of presynaptic membrane potential	IMP	J:172304
Molecular Function	GO:0005216	monoatomic ion channel activity	IEA	J:72247
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding	ISO	J:155856
Molecular Function	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	ISO	J:155856
Molecular Function	GO:0005267	potassium channel activity	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:96808
Molecular Function	GO:0005515	protein binding	IPI	J:302698
Molecular Function	GO:0005272	sodium channel activity	IEA	J:60000
Molecular Function	GO:0022843	voltage-gated monoatomic cation channel activity	ISO	J:164563
Molecular Function	GO:0005244	voltage-gated monoatomic ion channel activity	IEA	J:60000
Molecular Function	GO:0005249	voltage-gated potassium channel activity	IMP	J:202583
Molecular Function	GO:0005249	voltage-gated potassium channel activity	ISO	J:164563
Molecular Function	GO:0005249	voltage-gated potassium channel activity	IBA	J:265628
Molecular Function	GO:0005248	voltage-gated sodium channel activity	ISO	J:164563
Cellular Component	GO:0097440	apical dendrite	ISO	J:155856
Cellular Component	GO:0030424	axon	ISO	J:155856
Cellular Component	GO:0030424	axon	IBA	J:265628
Cellular Component	GO:0030424	axon	IDA	J:93895
Cellular Component	GO:0043679	axon terminus	ISO	J:155856
Cellular Component	GO:0016323	basolateral plasma membrane	ISO	J:155856
Cellular Component	GO:0009986	cell surface	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0030425	dendrite	ISO	J:155856
Cellular Component	GO:0030425	dendrite	IBA	J:265628
Cellular Component	GO:0030425	dendrite	IDA	J:96808
Cellular Component	GO:0030425	dendrite	IDA	J:96808
Cellular Component	GO:0030425	dendrite	IDA	J:96808
Cellular Component	GO:0030425	dendrite	IDA	J:96808
Cellular Component	GO:0030425	dendrite	IDA	J:96808
Cellular Component	GO:0032590	dendrite membrane	ISO	J:155856
Cellular Component	GO:0043198	dendritic shaft	ISO	J:155856
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:172304
Cellular Component	GO:0098978	glutamatergic synapse	EXP	J:172304
Cellular Component	GO:0098978	glutamatergic synapse	IMP	J:172304
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:136886
Cellular Component	GO:0098978	glutamatergic synapse	IMP	J:136886
Cellular Component	GO:0098978	glutamatergic synapse	EXP	J:136886
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:136886
Cellular Component	GO:0098855	HCN channel complex	ISO	J:164563
Cellular Component	GO:0098855	HCN channel complex	IPI	J:202583
Cellular Component	GO:0098855	HCN channel complex	IBA	J:265628
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0043025	neuronal cell body	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	IMP	J:202583
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IDA	J:302698
Cellular Component	GO:0045211	postsynaptic membrane	IDA	J:172304
Cellular Component	GO:0045211	postsynaptic membrane	IDA	J:172304
Cellular Component	GO:0048787	presynaptic active zone membrane	IDA	J:172304
Cellular Component	GO:0048787	presynaptic active zone membrane	IDA	J:172304
Cellular Component	GO:0036477	somatodendritic compartment	ISO	J:155856
Cellular Component	GO:0045202	synapse	ISO	J:155856
Biological Process	GO:0045176	apical protein localization	IMP	J:96808
Biological Process	GO:0071320	cellular response to cAMP	IDA	J:202583
Biological Process	GO:0071320	cellular response to cAMP	ISO	J:164563
Biological Process	GO:0071320	cellular response to cAMP	IMP	J:202583
Biological Process	GO:0051867	general adaptation syndrome, behavioral process	IDA	J:302698
Biological Process	GO:0006811	monoatomic ion transport	IEA	J:72247
Biological Process	GO:0006811	monoatomic ion transport	IEA	J:60000
Biological Process	GO:0045759	negative regulation of action potential	ISO	J:155856
Biological Process	GO:0051967	negative regulation of synaptic transmission, glutamatergic	IDA	J:172304
Biological Process	GO:0019228	neuronal action potential	IDA	J:302698
Biological Process	GO:2001259	positive regulation of cation channel activity	ISO	J:155856
Biological Process	GO:1902632	positive regulation of membrane hyperpolarization	ISO	J:155856
Biological Process	GO:0071805	potassium ion transmembrane transport	ISO	J:164563
Biological Process	GO:0071805	potassium ion transmembrane transport	IMP	J:202583
Biological Process	GO:0071805	potassium ion transmembrane transport	IBA	J:265628
Biological Process	GO:0006813	potassium ion transport	IEA	J:72247
Biological Process	GO:0006813	potassium ion transport	IEA	J:60000
Biological Process	GO:0051289	protein homotetramerization	ISO	J:164563
Biological Process	GO:2001257	regulation of cation channel activity	NAS	J:320090
Biological Process	GO:0086091	regulation of heart rate by cardiac conduction	NAS	J:320090
Biological Process	GO:0003254	regulation of membrane depolarization	ISO	J:164563
Biological Process	GO:0003254	regulation of membrane depolarization	ISO	J:155856
Biological Process	GO:0003254	regulation of membrane depolarization	IBA	J:265628
Biological Process	GO:1902630	regulation of membrane hyperpolarization	ISO	J:155856
Biological Process	GO:0042391	regulation of membrane potential	ISO	J:164563
Biological Process	GO:0034765	regulation of monoatomic ion transmembrane transport	IEA	J:60000
Biological Process	GO:0060078	regulation of postsynaptic membrane potential	EXP	J:136886
Biological Process	GO:0060078	regulation of postsynaptic membrane potential	IDA	J:136886
Biological Process	GO:0060078	regulation of postsynaptic membrane potential	IMP	J:136886
Biological Process	GO:0060078	regulation of postsynaptic membrane potential	IDA	J:136886
Biological Process	GO:0098907	regulation of SA node cell action potential	NAS	J:320090
Biological Process	GO:0051592	response to calcium ion	ISO	J:155856
Biological Process	GO:0046549	retinal cone cell development	IMP	J:166679
Biological Process	GO:0035725	sodium ion transmembrane transport	ISO	J:164563
Biological Process	GO:0035725	sodium ion transmembrane transport	IBA	J:265628
Biological Process	GO:0006814	sodium ion transport	IEA	J:60000
Biological Process	GO:0055085	transmembrane transport	IEA	J:72247

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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