GO Annotations Graph

• Symbol: Polr1a
• Name: polymerase (RNA) I polypeptide A
• ID: MGI:1096397

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003682	chromatin binding	ISO	J:164563
Molecular Function	GO:0003677	DNA binding	IEA	J:72247
Molecular Function	GO:0003899	DNA-directed 5'-3' RNA polymerase activity	ISO	J:155856
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0016779	nucleotidyltransferase activity	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:91576
Molecular Function	GO:0005515	protein binding	IPI	J:91576
Molecular Function	GO:0005515	protein binding	IPI	J:41855
Molecular Function	GO:0001054	RNA polymerase I activity	ISO	J:164563
Molecular Function	GO:0001054	RNA polymerase I activity	IBA	J:265628
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Molecular Function	GO:0008270	zinc ion binding	IEA	J:72247
Cellular Component	GO:0005694	chromosome	IDA	J:268520
Cellular Component	GO:0005694	chromosome	IDA	J:297328
Cellular Component	GO:0000428	DNA-directed RNA polymerase complex	IEA	J:60000
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-573384
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-73747
Cellular Component	GO:0005634	nucleus	IDA	J:41855
Cellular Component	GO:0005736	RNA polymerase I complex	ISO	J:155856
Cellular Component	GO:0005736	RNA polymerase I complex	IBA	J:265628
Cellular Component	GO:0005736	RNA polymerase I complex	IDA	J:41855
Cellular Component	GO:0005736	RNA polymerase I complex	IDA	J:91576
Biological Process	GO:0006351	DNA-templated transcription	IEA	J:72247
Biological Process	GO:1904750	negative regulation of protein localization to nucleolus	ISO	J:164563
Biological Process	GO:0009303	rRNA transcription	ISO	J:155856