GO Annotations Graph

• Symbol: Irf4
• Name: interferon regulatory factor 4
• ID: MGI:1096873

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0000987	cis-regulatory region sequence-specific DNA binding	IMP	J:268259
Molecular Function	GO:0003677	DNA binding	IEA	J:60000
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	ISO	J:164563
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IDA	J:190118
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IDA	J:189230
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IDA	J:188767
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	J:265628
Molecular Function	GO:0005515	protein binding	IPI	J:214637
Molecular Function	GO:0005515	protein binding	IPI	J:224866
Molecular Function	GO:0005515	protein binding	IPI	J:188767
Molecular Function	GO:0005515	protein binding	IPI	J:189230
Molecular Function	GO:0005515	protein binding	IPI	J:188993
Molecular Function	GO:0005515	protein binding	IPI	J:190118
Molecular Function	GO:0005515	protein binding	IPI	J:102933
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO	J:164563
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA	J:265628
Molecular Function	GO:0043565	sequence-specific DNA binding	IDA	J:189230
Molecular Function	GO:0043565	sequence-specific DNA binding	IDA	J:188767
Molecular Function	GO:0043565	sequence-specific DNA binding	IDA	J:190118
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	ISO	J:164563
Molecular Function	GO:0000976	transcription cis-regulatory region binding	IEA	J:72247
Molecular Function	GO:0003713	transcription coactivator activity	IDA	J:268259
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0000786	nucleosome	IDA	J:105503
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Biological Process	GO:0006338	chromatin remodeling	IMP	J:105503
Biological Process	GO:0042832	defense response to protozoan	IMP	J:188767
Biological Process	GO:0002376	immune system process	IBA	J:265628
Biological Process	GO:0043011	myeloid dendritic cell differentiation	IMP	J:188767
Biological Process	GO:0043011	myeloid dendritic cell differentiation	IMP	J:91043
Biological Process	GO:0034122	negative regulation of toll-like receptor signaling pathway	IMP	J:102933
Biological Process	GO:0120162	positive regulation of cold-induced thermogenesis	IMP	J:214637
Biological Process	GO:0043388	positive regulation of DNA binding	IMP	J:105503
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IGI	J:247193
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IDA	J:268259
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0032733	positive regulation of interleukin-10 production	ISO	J:164563
Biological Process	GO:0032736	positive regulation of interleukin-13 production	ISO	J:164563
Biological Process	GO:0032743	positive regulation of interleukin-2 production	ISO	J:164563
Biological Process	GO:0032753	positive regulation of interleukin-4 production	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:105503
Biological Process	GO:0006355	regulation of DNA-templated transcription	IEA	J:72247
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0072540	T-helper 17 cell lineage commitment	IMP	J:190118