GO Annotations Graph

• Symbol: Fxn
• Name: frataxin
• ID: MGI:1096879

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0051537	2 iron, 2 sulfur cluster binding	ISO	J:164563
Molecular Function	GO:0051537	2 iron, 2 sulfur cluster binding	IBA	J:265628
Molecular Function	GO:0019899	enzyme binding	ISO	J:155856
Molecular Function	GO:0008199	ferric iron binding	ISO	J:164563
Molecular Function	GO:0008199	ferric iron binding	IBA	J:265628
Molecular Function	GO:0008198	ferrous iron binding	ISO	J:164563
Molecular Function	GO:0008198	ferrous iron binding	IBA	J:265628
Molecular Function	GO:0004322	ferroxidase activity	ISO	J:164563
Molecular Function	GO:0004322	ferroxidase activity	IBA	J:265628
Molecular Function	GO:0034986	iron chaperone activity	ISO	J:164563
Molecular Function	GO:0034986	iron chaperone activity	IBA	J:265628
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0016491	oxidoreductase activity	IEA	J:60000
Cellular Component	GO:0005737	cytoplasm	IEA	J:60000
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:1990229	iron-sulfur cluster assembly complex	NAS	J:320071
Cellular Component	GO:1990221	L-cysteine desulfurase complex	ISO	J:164563
Cellular Component	GO:0099128	mitochondrial iron-sulfur cluster assembly complex	IDA	J:327042
Cellular Component	GO:0099128	mitochondrial iron-sulfur cluster assembly complex	IDA	J:326895
Cellular Component	GO:0099128	mitochondrial iron-sulfur cluster assembly complex	ISO	J:164563
Cellular Component	GO:0005739	mitochondrion	ISO	J:155856
Cellular Component	GO:0005739	mitochondrion	NAS	J:320072
Cellular Component	GO:0005739	mitochondrion	ISO	J:164563
Cellular Component	GO:0005739	mitochondrion	IBA	J:265628
Cellular Component	GO:0005739	mitochondrion	IDA	J:129870
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005739	mitochondrion	HDA	J:151002
Biological Process	GO:0044571	[2Fe-2S] cluster assembly	ISO	J:164563
Biological Process	GO:0044572	[4Fe-4S] cluster assembly	IDA	J:326895
Biological Process	GO:0044572	[4Fe-4S] cluster assembly	ISO	J:164563
Biological Process	GO:0007628	adult walking behavior	IMP	J:74420
Biological Process	GO:0007628	adult walking behavior	IMP	J:90083
Biological Process	GO:0009060	aerobic respiration	IMP	J:74420
Biological Process	GO:0009060	aerobic respiration	IMP	J:104119
Biological Process	GO:0070301	cellular response to hydrogen peroxide	ISO	J:164563
Biological Process	GO:0009792	embryo development ending in birth or egg hatching	IMP	J:62185
Biological Process	GO:0006783	heme biosynthetic process	IEA	J:60000
Biological Process	GO:0006879	intracellular iron ion homeostasis	ISO	J:164563
Biological Process	GO:0006879	intracellular iron ion homeostasis	IBA	J:265628
Biological Process	GO:0006879	intracellular iron ion homeostasis	IMP	J:74420
Biological Process	GO:0018283	iron incorporation into metallo-sulfur cluster	ISO	J:164563
Biological Process	GO:0018283	iron incorporation into metallo-sulfur cluster	IBA	J:265628
Biological Process	GO:0016226	iron-sulfur cluster assembly	NAS	J:320071
Biological Process	GO:0016226	iron-sulfur cluster assembly	ISO	J:164563
Biological Process	GO:0016226	iron-sulfur cluster assembly	IMP	J:129870
Biological Process	GO:0016226	iron-sulfur cluster assembly	IMP	J:104119
Biological Process	GO:0016226	iron-sulfur cluster assembly	IMP	J:129870
Biological Process	GO:0007005	mitochondrion organization	IMP	J:90083
Biological Process	GO:0007005	mitochondrion organization	IMP	J:74420
Biological Process	GO:0006811	monoatomic ion transport	IEA	J:60000
Biological Process	GO:0046716	muscle cell cellular homeostasis	IMP	J:74420
Biological Process	GO:0043066	negative regulation of apoptotic process	ISO	J:164563
Biological Process	GO:0040015	negative regulation of multicellular organism growth	IMP	J:120849
Biological Process	GO:0046621	negative regulation of organ growth	IMP	J:74420
Biological Process	GO:0090201	negative regulation of release of cytochrome c from mitochondria	ISO	J:164563
Biological Process	GO:0035265	organ growth	IMP	J:74420
Biological Process	GO:0006119	oxidative phosphorylation	IMP	J:120849
Biological Process	GO:0006119	oxidative phosphorylation	IMP	J:104119
Biological Process	GO:1904234	positive regulation of aconitate hydratase activity	ISO	J:164563
Biological Process	GO:0045773	positive regulation of axon extension	ISO	J:155856
Biological Process	GO:0043085	positive regulation of catalytic activity	ISO	J:164563
Biological Process	GO:0030307	positive regulation of cell growth	ISO	J:164563
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:164563
Biological Process	GO:0051349	positive regulation of lyase activity	ISO	J:164563
Biological Process	GO:1904231	positive regulation of succinate dehydrogenase activity	ISO	J:164563
Biological Process	GO:0019230	proprioception	IMP	J:90083
Biological Process	GO:0019230	proprioception	IMP	J:75420
Biological Process	GO:0016540	protein autoprocessing	ISO	J:164563
Biological Process	GO:0010722	regulation of ferrochelatase activity	ISO	J:164563
Biological Process	GO:0010039	response to iron ion	ISO	J:164563