GO Annotations Graph

• Symbol: Ptgis
• Name: prostaglandin I2 (prostacyclin) synthase
• ID: MGI:1097156

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0020037	heme binding	ISO	J:164563
Molecular Function	GO:0106256	hydroperoxy icosatetraenoate dehydratase activity	IEA	J:72245
Molecular Function	GO:0005506	iron ion binding	IEA	J:72247
Molecular Function	GO:0016853	isomerase activity	IEA	J:60000
Molecular Function	GO:0016829	lyase activity	IEA	J:60000
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0004497	monooxygenase activity	IEA	J:72247
Molecular Function	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	IEA	J:72247
Molecular Function	GO:0008116	prostaglandin-I synthase activity	ISO	J:155856
Molecular Function	GO:0008116	prostaglandin-I synthase activity	ISO	J:164563
Molecular Function	GO:0008116	prostaglandin-I synthase activity	IBA	J:265628
Cellular Component	GO:0005901	caveola	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IDA	J:56144
Cellular Component	GO:0005783	endoplasmic reticulum	ISO	J:164563
Cellular Component	GO:0005615	extracellular space	ISO	J:155856
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IDA	J:56144
Biological Process	GO:0097190	apoptotic signaling pathway	ISO	J:164563
Biological Process	GO:0071456	cellular response to hypoxia	ISO	J:164563
Biological Process	GO:0046697	decidualization	IDA	J:56144
Biological Process	GO:0007566	embryo implantation	IDA	J:56144
Biological Process	GO:0006633	fatty acid biosynthetic process	IEA	J:60000
Biological Process	GO:0006631	fatty acid metabolic process	IEA	J:60000
Biological Process	GO:0006690	icosanoid metabolic process	ISO	J:164563
Biological Process	GO:0006629	lipid metabolic process	IEA	J:60000
Biological Process	GO:0050728	negative regulation of inflammatory response	ISO	J:164563
Biological Process	GO:0032088	negative regulation of NF-kappaB transcription factor activity	ISO	J:164563
Biological Process	GO:0045019	negative regulation of nitric oxide biosynthetic process	ISO	J:164563
Biological Process	GO:0045766	positive regulation of angiogenesis	ISO	J:164563
Biological Process	GO:1900119	positive regulation of execution phase of apoptosis	ISO	J:164563
Biological Process	GO:0035360	positive regulation of peroxisome proliferator activated receptor signaling pathway	ISO	J:164563
Biological Process	GO:0001516	prostaglandin biosynthetic process	ISO	J:155856
Biological Process	GO:0001516	prostaglandin biosynthetic process	ISO	J:164563
Biological Process	GO:0001516	prostaglandin biosynthetic process	IBA	J:265628
Biological Process	GO:0006693	prostaglandin metabolic process	IEA	J:60000
Biological Process	GO:0001666	response to hypoxia	ISO	J:155856