GO Annotations Graph

• Symbol: Bak1
• Name: BCL2-antagonist/killer 1
• ID: MGI:1097161

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0051400	BH domain binding	ISO	J:155856
Molecular Function	GO:0031072	heat shock protein binding	ISO	J:155856
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0042802	identical protein binding	IPI	J:172906
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0042802	identical protein binding	ISO	J:155856
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0015288	porin activity	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:182407
Molecular Function	GO:0005515	protein binding	IPI	J:168877
Molecular Function	GO:0005515	protein binding	IPI	J:235310
Molecular Function	GO:0005515	protein binding	IPI	J:108337
Molecular Function	GO:0005515	protein binding	IPI	J:247400
Molecular Function	GO:0005515	protein binding	IPI	J:122960
Molecular Function	GO:0005515	protein binding	IPI	J:172906
Molecular Function	GO:0005515	protein binding	IPI	J:164708
Molecular Function	GO:0005515	protein binding	IPI	J:173142
Molecular Function	GO:0005515	protein binding	IPI	J:138066
Molecular Function	GO:0046982	protein heterodimerization activity	ISO	J:164563
Molecular Function	GO:0046982	protein heterodimerization activity	IBA	J:265628
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:164563
Molecular Function	GO:0042803	protein homodimerization activity	IBA	J:265628
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:155856
Molecular Function	GO:0051087	protein-folding chaperone binding	ISO	J:155856
Molecular Function	GO:0044325	transmembrane transporter binding	ISO	J:164563
Cellular Component	GO:0097145	BAK complex	IPI	J:313851
Cellular Component	GO:0097145	BAK complex	IDA	J:172906
Cellular Component	GO:0097145	BAK complex	ISO	J:164563
Cellular Component	GO:0097136	Bcl-2 family protein complex	ISO	J:164563
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0005829	cytosol	IDA	J:84272
Cellular Component	GO:0005783	endoplasmic reticulum	IDA	J:84272
Cellular Component	GO:0005622	intracellular anatomical structure	IDA	J:66494
Cellular Component	GO:0016020	membrane	ISO	J:155856
Cellular Component	GO:0031966	mitochondrial membrane	IDA	J:76215
Cellular Component	GO:0005741	mitochondrial outer membrane	ISO	J:164563
Cellular Component	GO:0005741	mitochondrial outer membrane	IDA	J:172906
Cellular Component	GO:0005741	mitochondrial outer membrane	IBA	J:265628
Cellular Component	GO:0005739	mitochondrion	ISO	J:155856
Cellular Component	GO:0005739	mitochondrion	ISO	J:164563
Cellular Component	GO:0005739	mitochondrion	IDA	J:84272
Cellular Component	GO:0005739	mitochondrion	HDA	J:151002
Cellular Component	GO:0005739	mitochondrion	IDA	J:167678
Cellular Component	GO:0005739	mitochondrion	IDA	J:113296
Cellular Component	GO:0046930	pore complex	ISO	J:164563
Biological Process	GO:0097202	activation of cysteine-type endopeptidase activity	ISO	J:164563
Biological Process	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	IGI	J:84272
Biological Process	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	IMP	J:112620
Biological Process	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	IGI	J:97306
Biological Process	GO:0008635	activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c	IMP	J:76058
Biological Process	GO:0006915	apoptotic process	ISO	J:155856
Biological Process	GO:0006915	apoptotic process	ISO	J:164563
Biological Process	GO:1902262	apoptotic process involved in blood vessel morphogenesis	IGI	J:115735
Biological Process	GO:1902262	apoptotic process involved in blood vessel morphogenesis	IGI	J:115735
Biological Process	GO:0097190	apoptotic signaling pathway	ISO	J:164563
Biological Process	GO:0001783	B cell apoptotic process	IGI	J:100463
Biological Process	GO:0001782	B cell homeostasis	IMP	J:100463
Biological Process	GO:0001782	B cell homeostasis	IGI	J:99285
Biological Process	GO:0002352	B cell negative selection	IGI	J:100463
Biological Process	GO:0001974	blood vessel remodeling	IGI	J:115735
Biological Process	GO:0060402	calcium ion transport into cytosol	IGI	J:95748
Biological Process	GO:0034644	cellular response to UV	ISO	J:164563
Biological Process	GO:0034644	cellular response to UV	IMP	J:114727
Biological Process	GO:0050673	epithelial cell proliferation	IDA	J:40808
Biological Process	GO:0051649	establishment of localization in cell	IGI	J:95748
Biological Process	GO:0010248	establishment or maintenance of transmembrane electrochemical gradient	ISO	J:164563
Biological Process	GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand	IBA	J:265628
Biological Process	GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand	IGI	J:99285
Biological Process	GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand	IGI	J:97305
Biological Process	GO:0044346	fibroblast apoptotic process	IMP	J:114727
Biological Process	GO:0048872	homeostasis of number of cells	IGI	J:66872
Biological Process	GO:0097193	intrinsic apoptotic signaling pathway	ISO	J:164563
Biological Process	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	IBA	J:265628
Biological Process	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	IMP	J:114727
Biological Process	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	IGI	J:114727
Biological Process	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	IGI	J:99285
Biological Process	GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	IGI	J:84272
Biological Process	GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	IGI	J:97306
Biological Process	GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	IGI	J:97306
Biological Process	GO:0001776	leukocyte homeostasis	IGI	J:99285
Biological Process	GO:0001776	leukocyte homeostasis	IGI	J:66872
Biological Process	GO:0035108	limb morphogenesis	IGI	J:66872
Biological Process	GO:0008053	mitochondrial fusion	IGI	J:113296
Biological Process	GO:0008053	mitochondrial fusion	IGI	J:112620
Biological Process	GO:0002262	myeloid cell homeostasis	IGI	J:99285
Biological Process	GO:0002262	myeloid cell homeostasis	IGI	J:99285
Biological Process	GO:0008285	negative regulation of cell population proliferation	ISO	J:155856
Biological Process	GO:0032471	negative regulation of endoplasmic reticulum calcium ion concentration	IGI	J:95748
Biological Process	GO:0032471	negative regulation of endoplasmic reticulum calcium ion concentration	IGI	J:95748
Biological Process	GO:0010629	negative regulation of gene expression	ISO	J:155856
Biological Process	GO:1901029	negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway	ISO	J:164563
Biological Process	GO:0033137	negative regulation of peptidyl-serine phosphorylation	IGI	J:95748
Biological Process	GO:0090201	negative regulation of release of cytochrome c from mitochondria	ISO	J:164563
Biological Process	GO:0018105	peptidyl-serine phosphorylation	IGI	J:95748
Biological Process	GO:0043065	positive regulation of apoptotic process	ISO	J:164563
Biological Process	GO:0043065	positive regulation of apoptotic process	IMP	J:235310
Biological Process	GO:0043065	positive regulation of apoptotic process	IMP	J:124814
Biological Process	GO:0010524	positive regulation of calcium ion transport into cytosol	IGI	J:95748
Biological Process	GO:1900103	positive regulation of endoplasmic reticulum unfolded protein response	ISO	J:164563
Biological Process	GO:1901030	positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway	NAS	J:313851
Biological Process	GO:0031334	positive regulation of protein-containing complex assembly	ISO	J:164563
Biological Process	GO:0045862	positive regulation of proteolysis	ISO	J:164563
Biological Process	GO:0090200	positive regulation of release of cytochrome c from mitochondria	ISO	J:155856
Biological Process	GO:0090200	positive regulation of release of cytochrome c from mitochondria	NAS	J:313851
Biological Process	GO:0048597	post-embryonic camera-type eye morphogenesis	IGI	J:115735
Biological Process	GO:0042981	regulation of apoptotic process	IEA	J:72247
Biological Process	GO:0051726	regulation of cell cycle	IGI	J:100463
Biological Process	GO:0046902	regulation of mitochondrial membrane permeability	ISO	J:164563
Biological Process	GO:0051881	regulation of mitochondrial membrane potential	ISO	J:164563
Biological Process	GO:0001836	release of cytochrome c from mitochondria	IMP	J:172906
Biological Process	GO:0001836	release of cytochrome c from mitochondria	ISO	J:164563
Biological Process	GO:0001836	release of cytochrome c from mitochondria	ISO	J:155856
Biological Process	GO:0009620	response to fungus	IMP	J:112620
Biological Process	GO:0010332	response to gamma radiation	IMP	J:124814
Biological Process	GO:0010046	response to mycotoxin	IMP	J:112620
Biological Process	GO:0070242	thymocyte apoptotic process	IGI	J:99285
Biological Process	GO:0070242	thymocyte apoptotic process	IGI	J:99285
Biological Process	GO:0060068	vagina development	IGI	J:66872