GO Annotations Graph

• Symbol: Nrg3
• Name: neuregulin 3
• ID: MGI:1097165

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0045499	chemorepellent activity	IBA	J:265628
Molecular Function	GO:0045499	chemorepellent activity	IDA	J:184363
Molecular Function	GO:0008083	growth factor activity	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:42826
Molecular Function	GO:0048018	receptor ligand activity	IPI	J:42826
Molecular Function	GO:0048018	receptor ligand activity	IPI	J:314758
Molecular Function	GO:0048018	receptor ligand activity	IPI	J:42826
Molecular Function	GO:0048018	receptor ligand activity	ISO	J:314758
Molecular Function	GO:0005102	signaling receptor binding	IEA	J:72247
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0005615	extracellular space	IBA	J:265628
Cellular Component	GO:0005615	extracellular space	ISO	J:314758
Cellular Component	GO:0005615	extracellular space	IPI	J:42826
Cellular Component	GO:0005615	extracellular space	ISO	J:314758
Cellular Component	GO:0005615	extracellular space	IDA	J:270203
Cellular Component	GO:0098978	glutamatergic synapse	ISO	J:164563
Cellular Component	GO:0098978	glutamatergic synapse	IMP	J:270203
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:270203
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:270203
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:270203
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005886	plasma membrane	IEA	J:60000
Cellular Component	GO:0045202	synapse	IMP	J:299110
Cellular Component	GO:0045202	synapse	IDA	J:299110
Cellular Component	GO:0045202	synapse	IDA	J:299110
Biological Process	GO:0048513	animal organ development	IBA	J:265628
Biological Process	GO:0021842	chemorepulsion involved in interneuron migration from the subpallium to the cortex	IMP	J:184363
Biological Process	GO:0038130	ERBB4 signaling pathway	ISO	J:314758
Biological Process	GO:0038130	ERBB4 signaling pathway	IPI	J:42826
Biological Process	GO:0038138	ERBB4-ERBB4 signaling pathway	IPI	J:42826
Biological Process	GO:0038138	ERBB4-ERBB4 signaling pathway	IPI	J:314758
Biological Process	GO:0035556	intracellular signal transduction	IBA	J:265628
Biological Process	GO:0035556	intracellular signal transduction	IDA	J:42826
Biological Process	GO:0030879	mammary gland development	IDA	J:100495
Biological Process	GO:0030879	mammary gland development	IMP	J:100495
Biological Process	GO:0060596	mammary placode formation	IMP	J:60708
Biological Process	GO:0050804	modulation of chemical synaptic transmission	ISO	J:164563
Biological Process	GO:2001223	negative regulation of neuron migration	IDA	J:184363
Biological Process	GO:0007399	nervous system development	IEA	J:72247
Biological Process	GO:0007389	pattern specification process	IMP	J:60708
Biological Process	GO:0007416	synapse assembly	IDA	J:270203
Biological Process	GO:0007416	synapse assembly	IDA	J:270203
Biological Process	GO:0007416	synapse assembly	IMP	J:270203
Biological Process	GO:0007416	synapse assembly	IDA	J:270203