GO Annotations Graph

• Symbol: Hdac2
• Name: histone deacetylase 2
• ID: MGI:1097691

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003682	chromatin binding	IDA	J:140120
Molecular Function	GO:0003682	chromatin binding	IDA	J:121427
Molecular Function	GO:0031490	chromatin DNA binding	IDA	J:136678
Molecular Function	GO:0019213	deacetylase activity	ISO	J:155856
Molecular Function	GO:0140297	DNA-binding transcription factor binding	TAS	J:113927
Molecular Function	GO:0140297	DNA-binding transcription factor binding	IPI	J:305429
Molecular Function	GO:0019899	enzyme binding	IPI	J:168151
Molecular Function	GO:0019899	enzyme binding	ISO	J:164563
Molecular Function	GO:0019899	enzyme binding	ISO	J:155856
Molecular Function	GO:0031072	heat shock protein binding	ISO	J:155856
Molecular Function	GO:0004407	histone deacetylase activity	ISO	J:164563
Molecular Function	GO:0004407	histone deacetylase activity	IDA	J:319948
Molecular Function	GO:0004407	histone deacetylase activity	IDA	J:209491
Molecular Function	GO:0004407	histone deacetylase activity	IDA	J:140120
Molecular Function	GO:0004407	histone deacetylase activity	TAS	J:113927
Molecular Function	GO:0004407	histone deacetylase activity	IBA	J:265628
Molecular Function	GO:0004407	histone deacetylase activity	IDA	J:121995
Molecular Function	GO:0004407	histone deacetylase activity	IGI	J:121995
Molecular Function	GO:0042826	histone deacetylase binding	ISO	J:164563
Molecular Function	GO:0160009	histone decrotonylase activity	ISO	J:164563
Molecular Function	GO:0160009	histone decrotonylase activity	IDA	J:319948
Molecular Function	GO:0034739	histone H4K16 deacetylase activity	IMP	J:219173
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0035851	Krueppel-associated box domain binding	IPI	J:205031
Molecular Function	GO:0035851	Krueppel-associated box domain binding	IPI	J:203400
Molecular Function	GO:0051059	NF-kappaB binding	ISO	J:164563
Molecular Function	GO:1990841	promoter-specific chromatin binding	ISO	J:155856
Molecular Function	GO:0005515	protein binding	IPI	J:319940
Molecular Function	GO:0005515	protein binding	IPI	J:123470
Molecular Function	GO:0005515	protein binding	IPI	J:160317
Molecular Function	GO:0005515	protein binding	IPI	J:209491
Molecular Function	GO:0005515	protein binding	IPI	J:118818
Molecular Function	GO:0005515	protein binding	IPI	J:148391
Molecular Function	GO:0005515	protein binding	IPI	J:162637
Molecular Function	GO:0005515	protein binding	IPI	J:245310
Molecular Function	GO:0005515	protein binding	IPI	J:203400
Molecular Function	GO:0005515	protein binding	IPI	J:207814
Molecular Function	GO:0005515	protein binding	IPI	J:237908
Molecular Function	GO:0005515	protein binding	IPI	J:206161
Molecular Function	GO:0005515	protein binding	IPI	J:76167
Molecular Function	GO:0005515	protein binding	IPI	J:76167
Molecular Function	GO:0005515	protein binding	IPI	J:121995
Molecular Function	GO:0005515	protein binding	IPI	J:81304
Molecular Function	GO:0005515	protein binding	IPI	J:76167
Molecular Function	GO:0005515	protein binding	IPI	J:76212
Molecular Function	GO:0005515	protein binding	IPI	J:164279
Molecular Function	GO:0005515	protein binding	IPI	J:76167
Molecular Function	GO:0005515	protein binding	IPI	J:76167
Molecular Function	GO:0005515	protein binding	IPI	J:66140
Molecular Function	GO:0005515	protein binding	IPI	J:76167
Molecular Function	GO:0005515	protein binding	IPI	J:152576
Molecular Function	GO:0160010	protein de-2-hydroxyisobutyrylase activity	ISO	J:164563
Molecular Function	GO:0033558	protein lysine deacetylase activity	IDA	J:140120
Molecular Function	GO:0033558	protein lysine deacetylase activity	ISO	J:164563
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	J:237908
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	J:211907
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	ISO	J:164563
Molecular Function	GO:0043565	sequence-specific DNA binding	ISO	J:164563
Molecular Function	GO:0001222	transcription corepressor binding	IPI	J:76061
Cellular Component	GO:0000785	chromatin	IDA	J:140120
Cellular Component	GO:0000785	chromatin	IDA	J:76061
Cellular Component	GO:0000785	chromatin	ISO	J:155856
Cellular Component	GO:0000781	chromosome, telomeric region	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	TAS	J:113927
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0035098	ESC/E(Z) complex	ISO	J:164563
Cellular Component	GO:0000792	heterochromatin	IDA	J:86958
Cellular Component	GO:0000792	heterochromatin	IDA	J:86958
Cellular Component	GO:0000792	heterochromatin	IDA	J:86777
Cellular Component	GO:0000118	histone deacetylase complex	ISO	J:164563
Cellular Component	GO:0000118	histone deacetylase complex	TAS	J:113927
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-573336
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-573376
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-573383
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9017958
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9625109
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-NUL-573373
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-NUL-573385
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	NAS	J:243422
Cellular Component	GO:0005634	nucleus	IDA	J:237908
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0005634	nucleus	IDA	J:227373
Cellular Component	GO:0005634	nucleus	IDA	J:168362
Cellular Component	GO:0016581	NuRD complex	NAS	J:319987
Cellular Component	GO:0016581	NuRD complex	ISO	J:164563
Cellular Component	GO:0016581	NuRD complex	IBA	J:265628
Cellular Component	GO:0032991	protein-containing complex	ISO	J:164563
Cellular Component	GO:0005657	replication fork	IDA	J:81304
Cellular Component	GO:0090571	RNA polymerase II transcription repressor complex	IDA	J:76061
Cellular Component	GO:0016580	Sin3 complex	NAS	J:243422
Cellular Component	GO:0016580	Sin3 complex	ISO	J:164563
Cellular Component	GO:0005667	transcription regulator complex	IPI	J:123890
Cellular Component	GO:0005667	transcription regulator complex	IPI	J:123890
Cellular Component	GO:0005667	transcription regulator complex	IPI	J:123890
Cellular Component	GO:0005667	transcription regulator complex	IPI	J:123890
Cellular Component	GO:0005667	transcription regulator complex	IPI	J:123890
Cellular Component	GO:0017053	transcription repressor complex	IPI	J:123890
Cellular Component	GO:0017053	transcription repressor complex	IPI	J:123890
Cellular Component	GO:0017053	transcription repressor complex	IPI	J:123890
Cellular Component	GO:0017053	transcription repressor complex	IPI	J:123890
Cellular Component	GO:0017053	transcription repressor complex	IPI	J:123890
Biological Process	GO:0055013	cardiac muscle cell development	IMP	J:121697
Biological Process	GO:0060038	cardiac muscle cell proliferation	IMP	J:121697
Biological Process	GO:0070301	cellular response to hydrogen peroxide	ISO	J:155856
Biological Process	GO:0035984	cellular response to trichostatin A	IDA	J:211907
Biological Process	GO:0006325	chromatin organization	TAS	J:113927
Biological Process	GO:0006338	chromatin remodeling	ISO	J:164563
Biological Process	GO:0032922	circadian regulation of gene expression	IDA	J:209491
Biological Process	GO:0016358	dendrite development	IMP	J:140120
Biological Process	GO:0042733	embryonic digit morphogenesis	IGI	J:168590
Biological Process	GO:0009913	epidermal cell differentiation	IGI	J:168590
Biological Process	GO:0061029	eyelid development in camera-type eye	IGI	J:168590
Biological Process	GO:0061198	fungiform papilla formation	IGI	J:168590
Biological Process	GO:0060789	hair follicle placode formation	IGI	J:168590
Biological Process	GO:0070828	heterochromatin organization	ISO	J:164563
Biological Process	GO:0021766	hippocampus development	IGI	J:148408
Biological Process	GO:0016575	histone deacetylation	ISO	J:164563
Biological Process	GO:0016575	histone deacetylation	IBA	J:265628
Biological Process	GO:0070932	histone H3 deacetylation	ISO	J:155856
Biological Process	GO:0043066	negative regulation of apoptotic process	IGI	J:168590
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	IGI	J:152576
Biological Process	GO:0060044	negative regulation of cardiac muscle cell proliferation	IMP	J:121697
Biological Process	GO:0030336	negative regulation of cell migration	NAS	J:320045
Biological Process	GO:0061000	negative regulation of dendritic spine development	ISO	J:155856
Biological Process	GO:0043392	negative regulation of DNA binding	ISO	J:155856
Biological Process	GO:0043433	negative regulation of DNA-binding transcription factor activity	ISO	J:164563
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	ISO	J:155856
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	IDA	J:140120
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	NAS	J:319679
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:2001243	negative regulation of intrinsic apoptotic signaling pathway	IGI	J:168590
Biological Process	GO:1902894	negative regulation of miRNA transcription	IGI	J:229793
Biological Process	GO:1902894	negative regulation of miRNA transcription	IMP	J:229793
Biological Process	GO:0010977	negative regulation of neuron projection development	IDA	J:140120
Biological Process	GO:0010977	negative regulation of neuron projection development	ISO	J:155856
Biological Process	GO:2000757	negative regulation of peptidyl-lysine acetylation	ISO	J:155856
Biological Process	GO:1902455	negative regulation of stem cell population maintenance	NAS	J:243422
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	NAS	J:320043
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	NAS	J:320044
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IGI	J:168590
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IGI	J:56497
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IGI	J:56497
Biological Process	GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	NAS	J:320045
Biological Process	GO:0030182	neuron differentiation	IGI	J:148408
Biological Process	GO:0042475	odontogenesis of dentin-containing tooth	IGI	J:168590
Biological Process	GO:0048709	oligodendrocyte differentiation	IGI	J:152576
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:155856
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:164563
Biological Process	GO:0008284	positive regulation of cell population proliferation	IGI	J:168590
Biological Process	GO:0051091	positive regulation of DNA-binding transcription factor activity	IDA	J:164279
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	NAS	J:156393
Biological Process	GO:0010718	positive regulation of epithelial to mesenchymal transition	ISO	J:155856
Biological Process	GO:0032732	positive regulation of interleukin-1 production	ISO	J:155856
Biological Process	GO:1902437	positive regulation of male mating behavior	ISO	J:155856
Biological Process	GO:0048714	positive regulation of oligodendrocyte differentiation	ISO	J:155856
Biological Process	GO:0048714	positive regulation of oligodendrocyte differentiation	IGI	J:152576
Biological Process	GO:0048714	positive regulation of oligodendrocyte differentiation	IGI	J:152576
Biological Process	GO:0045862	positive regulation of proteolysis	ISO	J:164563
Biological Process	GO:2000273	positive regulation of signaling receptor activity	ISO	J:164563
Biological Process	GO:1902459	positive regulation of stem cell population maintenance	NAS	J:243422
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	ISO	J:155856
Biological Process	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	ISO	J:155856
Biological Process	GO:0006476	protein deacetylation	IDA	J:140120
Biological Process	GO:0042659	regulation of cell fate specification	NAS	J:319679
Biological Process	GO:0090311	regulation of protein deacetylation	IGI	J:164279
Biological Process	GO:0051896	regulation of protein kinase B signaling	IMP	J:121697
Biological Process	GO:0060297	regulation of sarcomere organization	IMP	J:121697
Biological Process	GO:2000736	regulation of stem cell differentiation	NAS	J:319679
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0048511	rhythmic process	IEA	J:60000