GO Annotations Graph

• Symbol: Pik3cd
• Name: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
• ID: MGI:1098211

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0016303	1-phosphatidylinositol-3-kinase activity	IBA	J:265628
Molecular Function	GO:0035005	1-phosphatidylinositol-4-phosphate 3-kinase activity	IBA	J:265628
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0016301	kinase activity	ISO	J:217701
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0035004	phosphatidylinositol 3-kinase activity	IEA	J:72247
Molecular Function	GO:0052812	phosphatidylinositol-3,4-bisphosphate 5-kinase activity	IEA	J:72245
Molecular Function	GO:0046934	phosphatidylinositol-4,5-bisphosphate 3-kinase activity	IEA	J:72245
Molecular Function	GO:0005515	protein binding	IPI	J:196250
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9027268
Cellular Component	GO:0005942	phosphatidylinositol 3-kinase complex	IBA	J:265628
Cellular Component	GO:0005943	phosphatidylinositol 3-kinase complex, class IA	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IBA	J:265628
Biological Process	GO:0002250	adaptive immune response	IEA	J:60000
Biological Process	GO:0042113	B cell activation	IMP	J:79133
Biological Process	GO:0001782	B cell homeostasis	IMP	J:79133
Biological Process	GO:0030154	cell differentiation	IEA	J:60000
Biological Process	GO:0016477	cell migration	IBA	J:265628
Biological Process	GO:0007166	cell surface receptor signaling pathway	IMP	J:79133
Biological Process	GO:0006935	chemotaxis	IEA	J:60000
Biological Process	GO:0050832	defense response to fungus	IMP	J:206413
Biological Process	GO:0048872	homeostasis of number of cells	IMP	J:206413
Biological Process	GO:0002376	immune system process	IEA	J:60000
Biological Process	GO:0006954	inflammatory response	IEA	J:60000
Biological Process	GO:0045087	innate immune response	IEA	J:60000
Biological Process	GO:0006629	lipid metabolic process	IEA	J:60000
Biological Process	GO:0010629	negative regulation of gene expression	ISO	J:155856
Biological Process	GO:0014065	phosphatidylinositol 3-kinase signaling	ISO	J:164563
Biological Process	GO:0014065	phosphatidylinositol 3-kinase signaling	IBA	J:265628
Biological Process	GO:0046854	phosphatidylinositol phosphate biosynthetic process	IEA	J:72247
Biological Process	GO:0036092	phosphatidylinositol-3-phosphate biosynthetic process	IBA	J:265628
Biological Process	GO:0048015	phosphatidylinositol-mediated signaling	IEA	J:72247
Biological Process	GO:0016310	phosphorylation	ISO	J:217701
Biological Process	GO:0045766	positive regulation of angiogenesis	IMP	J:287007
Biological Process	GO:0030335	positive regulation of cell migration	ISO	J:164563
Biological Process	GO:0038089	positive regulation of cell migration by vascular endothelial growth factor signaling pathway	ISO	J:164563
Biological Process	GO:0010595	positive regulation of endothelial cell migration	ISO	J:164563
Biological Process	GO:0001938	positive regulation of endothelial cell proliferation	ISO	J:164563
Biological Process	GO:1905278	positive regulation of epithelial tube formation	ISO	J:164563
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:164563
Biological Process	GO:0010628	positive regulation of gene expression	IMP	J:206413
Biological Process	GO:0033031	positive regulation of neutrophil apoptotic process	ISO	J:164563
Biological Process	GO:0051897	positive regulation of protein kinase B signaling	ISO	J:164563
Biological Process	GO:0051897	positive regulation of protein kinase B signaling	IMP	J:287007