GO Annotations Graph

• Symbol: Alox8
• Name: arachidonate 8-lipoxygenase
• ID: MGI:1098228

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0050473	arachidonate 15-lipoxygenase activity	ISO	J:164563
Molecular Function	GO:0050473	arachidonate 15-lipoxygenase activity	IDA	J:236930
Molecular Function	GO:0050473	arachidonate 15-lipoxygenase activity	ISO	J:155856
Molecular Function	GO:0050473	arachidonate 15-lipoxygenase activity	IBA	J:265628
Molecular Function	GO:0047677	arachidonate 8(R)-lipoxygenase activity	IEA	J:72245
Molecular Function	GO:0036403	arachidonate 8(S)-lipoxygenase activity	IDA	J:287056
Molecular Function	GO:0036403	arachidonate 8(S)-lipoxygenase activity	IDA	J:133831
Molecular Function	GO:0036403	arachidonate 8(S)-lipoxygenase activity	IDA	J:200515
Molecular Function	GO:0036403	arachidonate 8(S)-lipoxygenase activity	IDA	J:43206
Molecular Function	GO:0005509	calcium ion binding	ISO	J:164563
Molecular Function	GO:0051213	dioxygenase activity	IEA	J:60000
Molecular Function	GO:0005506	iron ion binding	ISO	J:164563
Molecular Function	GO:0016165	linoleate 13S-lipoxygenase activity	ISO	J:164563
Molecular Function	GO:1990136	linoleate 9S-lipoxygenase activity	IDA	J:43206
Molecular Function	GO:0008289	lipid binding	IEA	J:60000
Molecular Function	GO:0046872	metal ion binding	IEA	J:72247
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0016491	oxidoreductase activity	IEA	J:60000
Molecular Function	GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	IEA	J:72247
Cellular Component	GO:0005912	adherens junction	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IEA	J:60000
Cellular Component	GO:0005856	cytoskeleton	ISO	J:164563
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0019898	extrinsic component of membrane	ISO	J:164563
Cellular Component	GO:0005925	focal adhesion	ISO	J:164563
Cellular Component	GO:0016020	membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Biological Process	GO:0019369	arachidonic acid metabolic process	ISO	J:155856
Biological Process	GO:0019369	arachidonic acid metabolic process	ISO	J:164563
Biological Process	GO:0019369	arachidonic acid metabolic process	IDA	J:43206
Biological Process	GO:1901696	cannabinoid biosynthetic process	ISO	J:164563
Biological Process	GO:0071926	endocannabinoid signaling pathway	ISO	J:164563
Biological Process	GO:0051122	hepoxilin biosynthetic process	ISO	J:155856
Biological Process	GO:0043651	linoleic acid metabolic process	IDA	J:43206
Biological Process	GO:0043651	linoleic acid metabolic process	IBA	J:265628
Biological Process	GO:0006629	lipid metabolic process	ISO	J:164563
Biological Process	GO:0034440	lipid oxidation	IBA	J:265628
Biological Process	GO:2001303	lipoxin A4 biosynthetic process	ISO	J:164563
Biological Process	GO:0019372	lipoxygenase pathway	ISO	J:155856
Biological Process	GO:0019372	lipoxygenase pathway	IDA	J:43206
Biological Process	GO:0045786	negative regulation of cell cycle	ISO	J:164563
Biological Process	GO:0008285	negative regulation of cell population proliferation	ISO	J:164563
Biological Process	GO:0045926	negative regulation of growth	ISO	J:164563
Biological Process	GO:0006644	phospholipid metabolic process	ISO	J:164563
Biological Process	GO:0006644	phospholipid metabolic process	IDA	J:236930
Biological Process	GO:0032722	positive regulation of chemokine production	ISO	J:164563
Biological Process	GO:0045618	positive regulation of keratinocyte differentiation	IMP	J:133831
Biological Process	GO:0010744	positive regulation of macrophage derived foam cell differentiation	ISO	J:164563
Biological Process	GO:0035360	positive regulation of peroxisome proliferator activated receptor signaling pathway	IMP	J:133831