GO Annotations Graph

• Symbol: P2rx1
• Name: purinergic receptor P2X, ligand-gated ion channel, 1
• ID: MGI:1098235

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	ISO	J:155856
Molecular Function	GO:0004931	extracellularly ATP-gated monoatomic cation channel activity	ISO	J:155856
Molecular Function	GO:0004931	extracellularly ATP-gated monoatomic cation channel activity	IBA	J:265628
Molecular Function	GO:0042802	identical protein binding	ISO	J:155856
Molecular Function	GO:0005261	monoatomic cation channel activity	ISO	J:73065
Molecular Function	GO:0005261	monoatomic cation channel activity	IMP	J:59336
Molecular Function	GO:0005216	monoatomic ion channel activity	IEA	J:72247
Molecular Function	GO:0000166	nucleotide binding	ISO	J:155856
Molecular Function	GO:0097159	organic cyclic compound binding	ISO	J:155856
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:155856
Molecular Function	GO:0001614	purinergic nucleotide receptor activity	IMP	J:59336
Molecular Function	GO:0001614	purinergic nucleotide receptor activity	ISO	J:73065
Molecular Function	GO:0043924	suramin binding	ISO	J:155856
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:102580
Cellular Component	GO:0098978	glutamatergic synapse	ISO	J:155856
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0045121	membrane raft	ISO	J:155856
Cellular Component	GO:0043005	neuron projection	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0045211	postsynaptic membrane	ISO	J:155856
Cellular Component	GO:0045211	postsynaptic membrane	IDA	J:74184
Cellular Component	GO:0048787	presynaptic active zone membrane	ISO	J:155856
Cellular Component	GO:0032991	protein-containing complex	ISO	J:155856
Biological Process	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	IDA	J:110330
Biological Process	GO:0006915	apoptotic process	IEA	J:60000
Biological Process	GO:0046513	ceramide biosynthetic process	IDA	J:110330
Biological Process	GO:0051649	establishment of localization in cell	IMP	J:59336
Biological Process	GO:0051649	establishment of localization in cell	IGI	J:118491
Biological Process	GO:0051649	establishment of localization in cell	IMP	J:118491
Biological Process	GO:0051649	establishment of localization in cell	IGI	J:118491
Biological Process	GO:0007320	insemination	IMP	J:59336
Biological Process	GO:0098655	monoatomic cation transmembrane transport	ISO	J:155856
Biological Process	GO:0034220	monoatomic ion transmembrane transport	ISO	J:155856
Biological Process	GO:0006811	monoatomic ion transport	IGI	J:118491
Biological Process	GO:0006811	monoatomic ion transport	IMP	J:118491
Biological Process	GO:0006811	monoatomic ion transport	IGI	J:118491
Biological Process	GO:0006811	monoatomic ion transport	IGI	J:118491
Biological Process	GO:0006811	monoatomic ion transport	ISO	J:73065
Biological Process	GO:0006811	monoatomic ion transport	IMP	J:118491
Biological Process	GO:0006811	monoatomic ion transport	IGI	J:118491
Biological Process	GO:0006811	monoatomic ion transport	IMP	J:59336
Biological Process	GO:0019228	neuronal action potential	ISO	J:155856
Biological Process	GO:0030168	platelet activation	IMP	J:85102
Biological Process	GO:1905665	positive regulation of calcium ion import across plasma membrane	ISO	J:155856
Biological Process	GO:0043270	positive regulation of monoatomic ion transport	IGI	J:118491
Biological Process	GO:0043270	positive regulation of monoatomic ion transport	IGI	J:118491
Biological Process	GO:0043270	positive regulation of monoatomic ion transport	IMP	J:118491
Biological Process	GO:0008217	regulation of blood pressure	ISO	J:155856
Biological Process	GO:0051924	regulation of calcium ion transport	IMP	J:116400
Biological Process	GO:0099509	regulation of presynaptic cytosolic calcium ion concentration	ISO	J:155856
Biological Process	GO:0006940	regulation of smooth muscle contraction	IMP	J:59336
Biological Process	GO:0006940	regulation of smooth muscle contraction	IMP	J:102580
Biological Process	GO:2000300	regulation of synaptic vesicle exocytosis	ISO	J:155856
Biological Process	GO:0003056	regulation of vascular associated smooth muscle contraction	IMP	J:116400
Biological Process	GO:0019229	regulation of vasoconstriction	IMP	J:118486
Biological Process	GO:0033198	response to ATP	IMP	J:118486
Biological Process	GO:0033198	response to ATP	IMP	J:101793
Biological Process	GO:0010033	response to organic substance	IMP	J:118491
Biological Process	GO:0002554	serotonin secretion by platelet	IMP	J:85102
Biological Process	GO:0035249	synaptic transmission, glutamatergic	ISO	J:155856