GO Annotations Graph

• Symbol: Nrg2
• Name: neuregulin 2
• ID: MGI:1098246

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005006	epidermal growth factor receptor activity	ISO	J:155856
Molecular Function	GO:0005154	epidermal growth factor receptor binding	ISO	J:155856
Molecular Function	GO:0043125	ErbB-3 class receptor binding	ISO	J:155856
Molecular Function	GO:1990631	ErbB-4 class receptor binding	ISO	J:202968
Molecular Function	GO:0048018	receptor ligand activity	IDA	J:106042
Molecular Function	GO:0048018	receptor ligand activity	ISO	J:314758
Molecular Function	GO:0048018	receptor ligand activity	IPI	J:42983
Molecular Function	GO:0048018	receptor ligand activity	IDA	J:42983
Molecular Function	GO:0048018	receptor ligand activity	IDA	J:317053
Molecular Function	GO:0005102	signaling receptor binding	IBA	J:265628
Cellular Component	GO:0005576	extracellular region	TAS	Reactome:R-NUL-9612654
Cellular Component	GO:0005615	extracellular space	IBA	J:265628
Cellular Component	GO:0005615	extracellular space	IDA	J:42983
Cellular Component	GO:0005615	extracellular space	IPI	J:42983
Cellular Component	GO:0005615	extracellular space	IDA	J:106042
Cellular Component	GO:0005615	extracellular space	ISO	J:314758
Cellular Component	GO:0005615	extracellular space	IDA	J:42983
Cellular Component	GO:0005615	extracellular space	IDA	J:317053
Cellular Component	GO:0098982	GABA-ergic synapse	ISO	J:155856
Cellular Component	GO:0098978	glutamatergic synapse	ISO	J:155856
Biological Process	GO:0048513	animal organ development	IBA	J:265628
Biological Process	GO:0007166	cell surface receptor signaling pathway	IDA	J:42983
Biological Process	GO:0007173	epidermal growth factor receptor signaling pathway	ISO	J:155856
Biological Process	GO:0038133	ERBB2-ERBB3 signaling pathway	IDA	J:317053
Biological Process	GO:0038130	ERBB4 signaling pathway	ISO	J:314758
Biological Process	GO:0038130	ERBB4 signaling pathway	IPI	J:42983
Biological Process	GO:0038130	ERBB4 signaling pathway	IDA	J:106042
Biological Process	GO:0038138	ERBB4-ERBB4 signaling pathway	IDA	J:42983
Biological Process	GO:0035556	intracellular signal transduction	IBA	J:265628
Biological Process	GO:0051963	regulation of synapse assembly	ISO	J:155856
Biological Process	GO:0090128	regulation of synapse maturation	ISO	J:155856