GO Annotations Graph

• Symbol: Cyp27b1
• Name: cytochrome P450, family 27, subfamily b, polypeptide 1
• ID: MGI:1098274

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0004498	calcidiol 1-monooxygenase activity	ISO	J:164563
Molecular Function	GO:0004498	calcidiol 1-monooxygenase activity	ISO	J:155856
Molecular Function	GO:0004498	calcidiol 1-monooxygenase activity	IDA	J:101035
Molecular Function	GO:0004498	calcidiol 1-monooxygenase activity	IDA	J:43146
Molecular Function	GO:0004498	calcidiol 1-monooxygenase activity	IBA	J:265628
Molecular Function	GO:0020037	heme binding	IEA	J:72247
Molecular Function	GO:0005506	iron ion binding	IEA	J:72247
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0004497	monooxygenase activity	IEA	J:60000
Molecular Function	GO:0004497	monooxygenase activity	IEA	J:72247
Molecular Function	GO:0016491	oxidoreductase activity	IEA	J:60000
Molecular Function	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	IEA	J:72247
Molecular Function	GO:0062185	secalciferol 1-monooxygenase activity	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005739	mitochondrion	ISO	J:155856
Cellular Component	GO:0005739	mitochondrion	IBA	J:265628
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005739	mitochondrion	HDA	J:151002
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Biological Process	GO:0007568	aging	ISO	J:155856
Biological Process	GO:0036378	calcitriol biosynthetic process from calciol	ISO	J:164563
Biological Process	GO:0036378	calcitriol biosynthetic process from calciol	IDA	J:101035
Biological Process	GO:0055074	calcium ion homeostasis	ISO	J:164563
Biological Process	GO:0006816	calcium ion transport	IMP	J:78635
Biological Process	GO:0070314	G1 to G0 transition	ISO	J:164563
Biological Process	GO:0006629	lipid metabolic process	IEA	J:60000
Biological Process	GO:1900155	negative regulation of bone trabecula formation	ISO	J:155856
Biological Process	GO:0010956	negative regulation of calcidiol 1-monooxygenase activity	ISO	J:164563
Biological Process	GO:0030308	negative regulation of cell growth	ISO	J:164563
Biological Process	GO:0008285	negative regulation of cell population proliferation	ISO	J:164563
Biological Process	GO:0030279	negative regulation of ossification	ISO	J:155856
Biological Process	GO:0045618	positive regulation of keratinocyte differentiation	ISO	J:164563
Biological Process	GO:2000830	positive regulation of parathyroid hormone secretion	ISO	J:155856
Biological Process	GO:0010980	positive regulation of vitamin D 24-hydroxylase activity	ISO	J:164563
Biological Process	GO:0070564	positive regulation of vitamin D receptor signaling pathway	ISO	J:164563
Biological Process	GO:0030500	regulation of bone mineralization	ISO	J:164563
Biological Process	GO:0051591	response to cAMP	ISO	J:155856
Biological Process	GO:0046688	response to copper ion	ISO	J:155856
Biological Process	GO:0032868	response to insulin	ISO	J:155856
Biological Process	GO:0032496	response to lipopolysaccharide	ISO	J:164563
Biological Process	GO:0034695	response to prostaglandin E	ISO	J:155856
Biological Process	GO:0034341	response to type II interferon	ISO	J:164563
Biological Process	GO:0033280	response to vitamin D	ISO	J:155856
Biological Process	GO:0033280	response to vitamin D	IDA	J:43146
Biological Process	GO:0033280	response to vitamin D	ISO	J:164563
Biological Process	GO:0009410	response to xenobiotic stimulus	ISO	J:155856
Biological Process	GO:0042369	vitamin D catabolic process	ISO	J:155856
Biological Process	GO:0042369	vitamin D catabolic process	IDA	J:43146
Biological Process	GO:0042359	vitamin D metabolic process	ISO	J:155856
Biological Process	GO:0042359	vitamin D metabolic process	ISO	J:164563