GO Annotations Graph

• Symbol: Eif2a
• Name: eukaryotic translation initiation factor 2A
• ID: MGI:1098684

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003729	mRNA binding	IBA	J:265628
Molecular Function	GO:0043022	ribosome binding	ISO	J:164563
Molecular Function	GO:0043022	ribosome binding	IBA	J:265628
Molecular Function	GO:0003743	translation initiation factor activity	ISO	J:164563
Molecular Function	GO:0003743	translation initiation factor activity	IBA	J:265628
Molecular Function	GO:0045182	translation regulator activity	TAS	J:171795
Molecular Function	GO:0000049	tRNA binding	ISO	J:164563
Molecular Function	GO:0000049	tRNA binding	IBA	J:265628
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0022627	cytosolic small ribosomal subunit	IBA	J:265628
Cellular Component	GO:0005850	eukaryotic translation initiation factor 2 complex	ISO	J:164563
Biological Process	GO:0030968	endoplasmic reticulum unfolded protein response	TAS	J:171795
Biological Process	GO:0017148	negative regulation of translation	TAS	J:171795
Biological Process	GO:1904294	positive regulation of ERAD pathway	TAS	J:171795
Biological Process	GO:0009967	positive regulation of signal transduction	IDA	J:141100
Biological Process	GO:0006468	protein phosphorylation	IDA	J:109619
Biological Process	GO:0006417	regulation of translation	ISO	J:164563
Biological Process	GO:1990928	response to amino acid starvation	ISO	J:155856
Biological Process	GO:0042255	ribosome assembly	ISO	J:164563
Biological Process	GO:0032933	SREBP signaling pathway	IDA	J:141100
Biological Process	GO:0006412	translation	IDA	J:19621
Biological Process	GO:0006413	translational initiation	ISO	J:164563