GO Annotations Graph

• Symbol: Aak1
• Name: AP2 associated kinase 1
• ID: MGI:1098687

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0035612	AP-2 adaptor complex binding	ISO	J:164563
Molecular Function	GO:0035612	AP-2 adaptor complex binding	ISO	J:155856
Molecular Function	GO:0005524	ATP binding	IEA	J:72247
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0016301	kinase activity	IEA	J:60000
Molecular Function	GO:0005112	Notch binding	ISO	J:164563
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0004672	protein kinase activity	IEA	J:72247
Molecular Function	GO:0004674	protein serine/threonine kinase activity	ISO	J:155856
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Cellular Component	GO:0044305	calyx of Held	ISO	J:155856
Cellular Component	GO:0031252	cell leading edge	ISO	J:155856
Cellular Component	GO:0042995	cell projection	IEA	J:60000
Cellular Component	GO:0071439	clathrin complex	ISO	J:155856
Cellular Component	GO:0005905	clathrin-coated pit	IEA	J:60000
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005886	plasma membrane	IEA	J:60000
Cellular Component	GO:0098793	presynapse	ISO	J:155856
Cellular Component	GO:0098793	presynapse	IDA	J:326665
Cellular Component	GO:0045202	synapse	IDA	J:326665
Cellular Component	GO:0043195	terminal bouton	ISO	J:155856
Biological Process	GO:0006897	endocytosis	IEA	J:60000
Biological Process	GO:0016310	phosphorylation	IEA	J:60000
Biological Process	GO:0045747	positive regulation of Notch signaling pathway	ISO	J:164563
Biological Process	GO:0140238	presynaptic endocytosis	ISO	J:155856
Biological Process	GO:0140238	presynaptic endocytosis	IDA	J:326665
Biological Process	GO:0140238	presynaptic endocytosis	IDA	J:326665
Biological Process	GO:0140238	presynaptic endocytosis	IMP	J:326665
Biological Process	GO:0140238	presynaptic endocytosis	IDA	J:326665
Biological Process	GO:0046777	protein autophosphorylation	ISO	J:155856
Biological Process	GO:0006468	protein phosphorylation	ISO	J:155856
Biological Process	GO:0006468	protein phosphorylation	ISO	J:164563
Biological Process	GO:0050821	protein stabilization	ISO	J:164563
Biological Process	GO:2000369	regulation of clathrin-dependent endocytosis	ISO	J:164563
Biological Process	GO:2000369	regulation of clathrin-dependent endocytosis	ISO	J:155856
Biological Process	GO:0032880	regulation of protein localization	ISO	J:164563