GO Annotations Graph

• Symbol: Pik3r2
• Name: phosphoinositide-3-kinase regulatory subunit 2
• ID: MGI:1098772

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0046935	1-phosphatidylinositol-3-kinase regulator activity	IBA	J:265628
Molecular Function	GO:0036312	phosphatidylinositol 3-kinase regulatory subunit binding	IPI	J:159304
Molecular Function	GO:0001784	phosphotyrosine residue binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:114108
Molecular Function	GO:0005515	protein binding	IPI	J:159304
Molecular Function	GO:0005515	protein binding	IPI	J:180006
Molecular Function	GO:0005515	protein binding	IPI	J:77039
Molecular Function	GO:0005515	protein binding	IPI	J:147628
Molecular Function	GO:0005515	protein binding	IPI	J:217307
Molecular Function	GO:0046982	protein heterodimerization activity	IPI	J:159304
Molecular Function	GO:0019903	protein phosphatase binding	ISO	J:164563
Molecular Function	GO:0030971	receptor tyrosine kinase binding	ISO	J:164563
Cellular Component	GO:0005925	focal adhesion	IDA	J:217307
Cellular Component	GO:0005634	nucleus	IDA	J:159304
Cellular Component	GO:0005634	nucleus	IDA	J:217307
Cellular Component	GO:0005942	phosphatidylinositol 3-kinase complex	IBA	J:265628
Cellular Component	GO:0005943	phosphatidylinositol 3-kinase complex, class IA	ISO	J:164563
Biological Process	GO:0032869	cellular response to insulin stimulus	IDA	J:159304
Biological Process	GO:0008286	insulin receptor signaling pathway	IMP	J:159304
Biological Process	GO:0008286	insulin receptor signaling pathway	IBA	J:265628
Biological Process	GO:0001678	intracellular glucose homeostasis	IDA	J:159304
Biological Process	GO:0090051	negative regulation of cell migration involved in sprouting angiogenesis	ISO	J:155856
Biological Process	GO:0043409	negative regulation of MAPK cascade	ISO	J:164563
Biological Process	GO:0014065	phosphatidylinositol 3-kinase signaling	ISO	J:164563
Biological Process	GO:0046854	phosphatidylinositol phosphate biosynthetic process	IBA	J:265628
Biological Process	GO:0045785	positive regulation of cell adhesion	IDA	J:217307
Biological Process	GO:0042307	positive regulation of protein import into nucleus	IMP	J:159304
Biological Process	GO:0042307	positive regulation of protein import into nucleus	IMP	J:159304
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:159304
Biological Process	GO:0015031	protein transport	IEA	J:60000
Biological Process	GO:0030833	regulation of actin filament polymerization	IMP	J:217307
Biological Process	GO:0010506	regulation of autophagy	ISO	J:164563
Biological Process	GO:0043551	regulation of phosphatidylinositol 3-kinase activity	IBA	J:265628
Biological Process	GO:1903076	regulation of protein localization to plasma membrane	IDA	J:217307
Biological Process	GO:0051492	regulation of stress fiber assembly	IMP	J:217307
Biological Process	GO:0034976	response to endoplasmic reticulum stress	IDA	J:159304
Biological Process	GO:0007165	signal transduction	IEA	J:72247