GO Annotations Graph

• Symbol: Cdk12
• Name: cyclin dependent kinase 12
• ID: MGI:1098802

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0005524	ATP binding	IEA	J:72247
Molecular Function	GO:0030332	cyclin binding	ISO	J:155856
Molecular Function	GO:0030332	cyclin binding	IBA	J:265628
Molecular Function	GO:0030332	cyclin binding	ISO	J:73065
Molecular Function	GO:0004693	cyclin-dependent protein serine/threonine kinase activity	IBA	J:265628
Molecular Function	GO:0016301	kinase activity	IEA	J:60000
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0004672	protein kinase activity	ISO	J:164563
Molecular Function	GO:0019901	protein kinase binding	IDA	J:192997
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IEA	J:60000
Molecular Function	GO:0008353	RNA polymerase II CTD heptapeptide repeat kinase activity	ISO	J:164563
Molecular Function	GO:0008353	RNA polymerase II CTD heptapeptide repeat kinase activity	IBA	J:265628
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Cellular Component	GO:0002944	cyclin K-CDK12 complex	ISO	J:73065
Cellular Component	GO:0008024	cyclin/CDK positive transcription elongation factor complex	IBA	J:265628
Cellular Component	GO:0019908	nuclear cyclin-dependent protein kinase holoenzyme complex	ISO	J:155856
Cellular Component	GO:0016607	nuclear speck	ISO	J:155856
Cellular Component	GO:0016607	nuclear speck	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Biological Process	GO:0006397	mRNA processing	IEA	J:60000
Biological Process	GO:2000737	negative regulation of stem cell differentiation	IMP	J:192997
Biological Process	GO:0016310	phosphorylation	IEA	J:60000
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0032968	positive regulation of transcription elongation by RNA polymerase II	IBA	J:265628
Biological Process	GO:0046777	protein autophosphorylation	ISO	J:164563
Biological Process	GO:0006468	protein phosphorylation	IEA	J:72247
Biological Process	GO:0043405	regulation of MAP kinase activity	ISO	J:164563
Biological Process	GO:0043484	regulation of RNA splicing	ISO	J:155856
Biological Process	GO:0008380	RNA splicing	ISO	J:155856
Biological Process	GO:0006366	transcription by RNA polymerase II	ISO	J:164563