GO Annotations Graph

• Symbol: Sptlc1
• Name: serine palmitoyltransferase, long chain base subunit 1
• ID: MGI:1099431

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0016746	acyltransferase activity	IEA	J:60000
Molecular Function	GO:0003824	catalytic activity	IEA	J:72247
Molecular Function	GO:0005515	protein binding	IPI	J:228796
Molecular Function	GO:0005515	protein binding	IPI	J:136952
Molecular Function	GO:0030170	pyridoxal phosphate binding	IEA	J:72247
Molecular Function	GO:0004758	serine C-palmitoyltransferase activity	IMP	J:240861
Molecular Function	GO:0004758	serine C-palmitoyltransferase activity	IBA	J:265628
Molecular Function	GO:0004758	serine C-palmitoyltransferase activity	ISO	J:221146
Molecular Function	GO:0004758	serine C-palmitoyltransferase activity	ISO	J:73065
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Cellular Component	GO:0005783	endoplasmic reticulum	ISO	J:164563
Cellular Component	GO:0005783	endoplasmic reticulum	IBA	J:265628
Cellular Component	GO:0005789	endoplasmic reticulum membrane	IDA	J:228796
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0017059	serine C-palmitoyltransferase complex	ISO	J:164563
Cellular Component	GO:0017059	serine C-palmitoyltransferase complex	ISA	J:44738
Cellular Component	GO:0035339	SPOTS complex	ISO	J:164563
Cellular Component	GO:0035339	SPOTS complex	ISO	J:221146
Biological Process	GO:0009058	biosynthetic process	IEA	J:72247
Biological Process	GO:0046513	ceramide biosynthetic process	IBA	J:265628
Biological Process	GO:0046513	ceramide biosynthetic process	IMP	J:140627
Biological Process	GO:0046513	ceramide biosynthetic process	ISO	J:221146
Biological Process	GO:0006629	lipid metabolic process	IEA	J:60000
Biological Process	GO:0061724	lipophagy	ISO	J:73065
Biological Process	GO:1904504	positive regulation of lipophagy	ISO	J:73065
Biological Process	GO:1904649	regulation of fat cell apoptotic process	IMP	J:240861
Biological Process	GO:0046511	sphinganine biosynthetic process	IMP	J:148766
Biological Process	GO:0030148	sphingolipid biosynthetic process	ISO	J:73065
Biological Process	GO:0006665	sphingolipid metabolic process	IMP	J:240861
Biological Process	GO:0006686	sphingomyelin biosynthetic process	IDA	J:228796
Biological Process	GO:0006686	sphingomyelin biosynthetic process	IMP	J:140627
Biological Process	GO:0006686	sphingomyelin biosynthetic process	ISA	J:44738
Biological Process	GO:0046512	sphingosine biosynthetic process	ISO	J:164563
Biological Process	GO:0046512	sphingosine biosynthetic process	IBA	J:265628
Biological Process	GO:0046512	sphingosine biosynthetic process	IMP	J:140627