GO Annotations Graph

• Symbol: Atxn3
• Name: ataxin 3
• ID: MGI:1099442

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0051117	ATPase binding	ISO	J:164563
Molecular Function	GO:0004843	cysteine-type deubiquitinase activity	IDA	J:183193
Molecular Function	GO:0004843	cysteine-type deubiquitinase activity	IBA	J:265628
Molecular Function	GO:0008234	cysteine-type peptidase activity	IEA	J:60000
Molecular Function	GO:0004407	histone deacetylase activity	ISO	J:155856
Molecular Function	GO:0042826	histone deacetylase binding	ISO	J:155856
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:1990380	K48-linked deubiquitinase activity	ISO	J:164563
Molecular Function	GO:0061578	K63-linked deubiquitinase activity	ISO	J:164563
Molecular Function	GO:0008233	peptidase activity	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:145209
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	ISO	J:155856
Molecular Function	GO:0001222	transcription corepressor binding	ISO	J:155856
Molecular Function	GO:0031625	ubiquitin protein ligase binding	ISO	J:164563
Molecular Function	GO:0031625	ubiquitin protein ligase binding	IPI	J:183193
Cellular Component	GO:0005737	cytoplasm	IDA	J:136856
Cellular Component	GO:0005737	cytoplasm	IDA	J:155356
Cellular Component	GO:0005737	cytoplasm	IDA	J:122993
Cellular Component	GO:0005737	cytoplasm	IDA	J:165379
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005789	endoplasmic reticulum membrane	ISO	J:164563
Cellular Component	GO:0005759	mitochondrial matrix	IDA	J:136856
Cellular Component	GO:0031966	mitochondrial membrane	IDA	J:136856
Cellular Component	GO:0042405	nuclear inclusion body	IDA	J:122993
Cellular Component	GO:0005730	nucleolus	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0005634	nucleus	IDA	J:136856
Cellular Component	GO:0005634	nucleus	IDA	J:165379
Cellular Component	GO:0005634	nucleus	IDA	J:155356
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Biological Process	GO:0030036	actin cytoskeleton organization	ISO	J:73065
Biological Process	GO:0034605	cellular response to heat	IMP	J:155356
Biological Process	GO:0071218	cellular response to misfolded protein	IMP	J:183193
Biological Process	GO:0035640	exploration behavior	IMP	J:145048
Biological Process	GO:0016570	histone modification	ISO	J:155856
Biological Process	GO:0045104	intermediate filament cytoskeleton organization	ISO	J:73065
Biological Process	GO:0000226	microtubule cytoskeleton organization	ISO	J:73065
Biological Process	GO:0035520	monoubiquitinated protein deubiquitination	IDA	J:183193
Biological Process	GO:1904294	positive regulation of ERAD pathway	ISO	J:164563
Biological Process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	IMP	J:183193
Biological Process	GO:0016579	protein deubiquitination	ISO	J:164563
Biological Process	GO:0016579	protein deubiquitination	IBA	J:265628
Biological Process	GO:0071108	protein K48-linked deubiquitination	ISO	J:164563
Biological Process	GO:0070536	protein K63-linked deubiquitination	ISO	J:164563
Biological Process	GO:1904379	protein localization to cytosolic proteasome complex involved in ERAD pathway	ISO	J:164563
Biological Process	GO:0006515	protein quality control for misfolded or incompletely synthesized proteins	IMP	J:183193
Biological Process	GO:0006508	proteolysis	IEA	J:60000
Biological Process	GO:0010810	regulation of cell-substrate adhesion	IMP	J:165449
Biological Process	GO:0010810	regulation of cell-substrate adhesion	ISO	J:73065
Biological Process	GO:0006511	ubiquitin-dependent protein catabolic process	IMP	J:145048
Biological Process	GO:0006511	ubiquitin-dependent protein catabolic process	IMP	J:145048