GO Annotations Graph

• Symbol: Plk2
• Name: polo like kinase 2
• ID: MGI:1099790

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0005524	ATP binding	IEA	J:72247
Molecular Function	GO:0043008	ATP-dependent protein binding	ISO	J:164563
Molecular Function	GO:0051117	ATPase binding	ISO	J:155856
Molecular Function	GO:0032050	clathrin heavy chain binding	ISO	J:155856
Molecular Function	GO:0051020	GTPase binding	ISO	J:155856
Molecular Function	GO:0016301	kinase activity	IEA	J:60000
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0004672	protein kinase activity	IEA	J:72247
Molecular Function	GO:0019901	protein kinase binding	ISO	J:155856
Molecular Function	GO:0004674	protein serine/threonine kinase activity	ISO	J:164563
Molecular Function	GO:0004674	protein serine/threonine kinase activity	ISO	J:155856
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IDA	J:180484
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IBA	J:265628
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:155856
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Cellular Component	GO:0042995	cell projection	IEA	J:60000
Cellular Component	GO:0005814	centriole	ISO	J:164563
Cellular Component	GO:0005814	centriole	IBA	J:265628
Cellular Component	GO:0005813	centrosome	ISO	J:164563
Cellular Component	GO:0005813	centrosome	IBA	J:265628
Cellular Component	GO:0000785	chromatin	IDA	J:199766
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005856	cytoskeleton	IEA	J:60000
Cellular Component	GO:0030425	dendrite	ISO	J:155856
Cellular Component	GO:0000776	kinetochore	IBA	J:265628
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9770046
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0000922	spindle pole	IBA	J:265628
Cellular Component	GO:0045202	synapse	ISO	J:155856
Biological Process	GO:0000082	G1/S transition of mitotic cell cycle	ISO	J:164563
Biological Process	GO:0000082	G1/S transition of mitotic cell cycle	IBA	J:265628
Biological Process	GO:0060292	long-term synaptic depression	ISO	J:155856
Biological Process	GO:0060291	long-term synaptic potentiation	ISO	J:155856
Biological Process	GO:0007613	memory	IMP	J:174739
Biological Process	GO:0000278	mitotic cell cycle	IMP	J:85756
Biological Process	GO:0007052	mitotic spindle organization	ISO	J:164563
Biological Process	GO:0007052	mitotic spindle organization	IMP	J:180484
Biological Process	GO:0007052	mitotic spindle organization	IBA	J:265628
Biological Process	GO:0016525	negative regulation of angiogenesis	IMP	J:230992
Biological Process	GO:0043066	negative regulation of apoptotic process	IMP	J:180484
Biological Process	GO:0071866	negative regulation of apoptotic process in bone marrow cell	IMP	J:257331
Biological Process	GO:2000773	negative regulation of cellular senescence	IMP	J:257331
Biological Process	GO:0061000	negative regulation of dendritic spine development	ISO	J:155856
Biological Process	GO:0090394	negative regulation of excitatory postsynaptic potential	ISO	J:155856
Biological Process	GO:0032091	negative regulation of protein binding	ISO	J:155856
Biological Process	GO:2000009	negative regulation of protein localization to cell surface	ISO	J:155856
Biological Process	GO:0018105	peptidyl-serine phosphorylation	ISO	J:164563
Biological Process	GO:0016310	phosphorylation	IEA	J:60000
Biological Process	GO:0010508	positive regulation of autophagy	ISO	J:164563
Biological Process	GO:0090050	positive regulation of cell migration involved in sprouting angiogenesis	IMP	J:257331
Biological Process	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	ISO	J:155856
Biological Process	GO:0032092	positive regulation of protein binding	ISO	J:155856
Biological Process	GO:0045732	positive regulation of protein catabolic process	ISO	J:164563
Biological Process	GO:0002092	positive regulation of receptor internalization	ISO	J:155856
Biological Process	GO:0006468	protein phosphorylation	ISO	J:155856
Biological Process	GO:0006468	protein phosphorylation	ISO	J:164563
Biological Process	GO:0006468	protein phosphorylation	IDA	J:180484
Biological Process	GO:0032486	Rap protein signal transduction	ISO	J:155856
Biological Process	GO:0007265	Ras protein signal transduction	ISO	J:155856
Biological Process	GO:0046599	regulation of centriole replication	ISO	J:164563
Biological Process	GO:0048167	regulation of synaptic plasticity	ISO	J:155856
Biological Process	GO:0048167	regulation of synaptic plasticity	IMP	J:174739
Biological Process	GO:0048167	regulation of synaptic plasticity	IBA	J:265628