GO Annotations Graph

• Symbol: Pkd2
• Name: polycystin 2, transient receptor potential cation channel
• ID: MGI:1099818

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0042805	actinin binding	ISO	J:164563
Molecular Function	GO:0051393	alpha-actinin binding	ISO	J:155856
Molecular Function	GO:0051117	ATPase binding	IPI	J:133467
Molecular Function	GO:0005262	calcium channel activity	IMP	J:240321
Molecular Function	GO:0005262	calcium channel activity	ISO	J:164563
Molecular Function	GO:0005262	calcium channel activity	IDA	J:82514
Molecular Function	GO:0005262	calcium channel activity	TAS	J:76062
Molecular Function	GO:0005509	calcium ion binding	IDA	J:182478
Molecular Function	GO:0005509	calcium ion binding	ISO	J:164563
Molecular Function	GO:0005509	calcium ion binding	IBA	J:265628
Molecular Function	GO:0048763	calcium-induced calcium release activity	ISO	J:164563
Molecular Function	GO:0015267	channel activity	IMP	J:143394
Molecular Function	GO:0008092	cytoskeletal protein binding	ISO	J:164563
Molecular Function	GO:0043398	HLH domain binding	ISO	J:164563
Molecular Function	GO:0042802	identical protein binding	IPI	J:182478
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0005261	monoatomic cation channel activity	ISO	J:164563
Molecular Function	GO:0051371	muscle alpha-actinin binding	ISO	J:155856
Molecular Function	GO:0051371	muscle alpha-actinin binding	IBA	J:265628
Molecular Function	GO:0015271	outward rectifier potassium channel activity	IMP	J:240321
Molecular Function	GO:0051219	phosphoprotein binding	ISO	J:164563
Molecular Function	GO:0005267	potassium channel activity	ISO	J:164563
Molecular Function	GO:0005267	potassium channel activity	IBA	J:265628
Molecular Function	GO:0005267	potassium channel activity	IDA	J:82514
Molecular Function	GO:0005515	protein binding	IPI	J:274079
Molecular Function	GO:0005515	protein binding	IPI	J:173554
Molecular Function	GO:0005515	protein binding	IPI	J:170490
Molecular Function	GO:0005515	protein binding	IPI	J:149929
Molecular Function	GO:0005515	protein binding	IPI	J:217259
Molecular Function	GO:0005515	protein binding	IPI	J:65183
Molecular Function	GO:0005515	protein binding	IPI	J:76062
Molecular Function	GO:0005515	protein binding	IPI	J:77086
Molecular Function	GO:0005515	protein binding	IPI	J:143394
Molecular Function	GO:0005515	protein binding	IPI	J:95937
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:164563
Molecular Function	GO:0005102	signaling receptor binding	ISO	J:164563
Molecular Function	GO:0005102	signaling receptor binding	IBA	J:265628
Molecular Function	GO:0005102	signaling receptor binding	IPI	J:120848
Molecular Function	GO:0044325	transmembrane transporter binding	ISO	J:164563
Molecular Function	GO:0005245	voltage-gated calcium channel activity	ISO	J:164563
Molecular Function	GO:0005245	voltage-gated calcium channel activity	IBA	J:265628
Molecular Function	GO:0022843	voltage-gated monoatomic cation channel activity	ISO	J:164563
Molecular Function	GO:0005244	voltage-gated monoatomic ion channel activity	ISO	J:164563
Molecular Function	GO:0005249	voltage-gated potassium channel activity	ISO	J:164563
Molecular Function	GO:0005248	voltage-gated sodium channel activity	ISO	J:164563
Molecular Function	GO:0005248	voltage-gated sodium channel activity	IBA	J:265628
Cellular Component	GO:0045180	basal cortex	ISO	J:164563
Cellular Component	GO:0045180	basal cortex	IDA	J:169812
Cellular Component	GO:0009925	basal plasma membrane	ISO	J:164563
Cellular Component	GO:0034703	cation channel complex	ISO	J:164563
Cellular Component	GO:0042995	cell projection	IEA	J:60000
Cellular Component	GO:0005911	cell-cell junction	IDA	J:182397
Cellular Component	GO:0036064	ciliary basal body	IDA	J:179756
Cellular Component	GO:0036064	ciliary basal body	ISO	J:73065
Cellular Component	GO:0060170	ciliary membrane	IMP	J:240321
Cellular Component	GO:0005929	cilium	IMP	J:170490
Cellular Component	GO:0005929	cilium	IDA	J:274079
Cellular Component	GO:0005929	cilium	IDA	J:182484
Cellular Component	GO:0005929	cilium	IDA	J:188763
Cellular Component	GO:0005929	cilium	IDA	J:246963
Cellular Component	GO:0005929	cilium	IDA	J:103305
Cellular Component	GO:0005929	cilium	IDA	J:82514
Cellular Component	GO:0005929	cilium	IDA	J:81443
Cellular Component	GO:0005929	cilium	ISO	J:246963
Cellular Component	GO:0005929	cilium	IDA	J:138625
Cellular Component	GO:0005737	cytoplasm	IDA	J:169812
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0098554	cytoplasmic side of endoplasmic reticulum membrane	ISO	J:164563
Cellular Component	GO:0031410	cytoplasmic vesicle	IEA	J:60000
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005783	endoplasmic reticulum	IDA	J:274079
Cellular Component	GO:0005783	endoplasmic reticulum	ISO	J:155856
Cellular Component	GO:0005783	endoplasmic reticulum	ISO	J:164563
Cellular Component	GO:0005783	endoplasmic reticulum	IMP	J:82514
Cellular Component	GO:0005783	endoplasmic reticulum	IDA	J:104127
Cellular Component	GO:0005783	endoplasmic reticulum	ISO	J:246963
Cellular Component	GO:0005783	endoplasmic reticulum	TAS	J:65183
Cellular Component	GO:0005789	endoplasmic reticulum membrane	ISO	J:164563
Cellular Component	GO:0005794	Golgi apparatus	IDA	J:274079
Cellular Component	GO:0030027	lamellipodium	ISO	J:164563
Cellular Component	GO:0098553	lumenal side of endoplasmic reticulum membrane	ISO	J:164563
Cellular Component	GO:0016020	membrane	ISO	J:155856
Cellular Component	GO:0016020	membrane	IBA	J:265628
Cellular Component	GO:0072686	mitotic spindle	IDA	J:182402
Cellular Component	GO:0072686	mitotic spindle	ISO	J:164563
Cellular Component	GO:0031514	motile cilium	IDA	J:99441
Cellular Component	GO:0031514	motile cilium	IDA	J:99441
Cellular Component	GO:0097730	non-motile cilium	IDA	J:77403
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IDA	J:82514
Cellular Component	GO:0002133	polycystin complex	IPI	J:77086
Cellular Component	GO:0002133	polycystin complex	IDA	J:274079
Cellular Component	GO:0002133	polycystin complex	ISO	J:164563
Cellular Component	GO:0002133	polycystin complex	IDA	J:77086
Biological Process	GO:0070588	calcium ion transmembrane transport	ISO	J:164563
Biological Process	GO:0070588	calcium ion transmembrane transport	IMP	J:240321
Biological Process	GO:0006816	calcium ion transport	IDA	J:81443
Biological Process	GO:0006816	calcium ion transport	ISO	J:164563
Biological Process	GO:0006816	calcium ion transport	IMP	J:81443
Biological Process	GO:0198738	cell-cell signaling by wnt	ISO	J:164563
Biological Process	GO:0071277	cellular response to calcium ion	IMP	J:240321
Biological Process	GO:0071320	cellular response to cAMP	ISO	J:164563
Biological Process	GO:0071498	cellular response to fluid shear stress	ISO	J:164563
Biological Process	GO:0071498	cellular response to fluid shear stress	IMP	J:182484
Biological Process	GO:0071464	cellular response to hydrostatic pressure	ISO	J:164563
Biological Process	GO:0071470	cellular response to osmotic stress	ISO	J:164563
Biological Process	GO:0044782	cilium organization	ISO	J:246963
Biological Process	GO:0042994	cytoplasmic sequestering of transcription factor	ISO	J:164563
Biological Process	GO:0050982	detection of mechanical stimulus	IBA	J:265628
Biological Process	GO:0050982	detection of mechanical stimulus	IMP	J:81443
Biological Process	GO:0003127	detection of nodal flow	IMP	J:170490
Biological Process	GO:0007368	determination of left/right symmetry	IMP	J:77401
Biological Process	GO:0071910	determination of liver left/right asymmetry	ISO	J:164563
Biological Process	GO:0001892	embryonic placenta development	IMP	J:165114
Biological Process	GO:0001892	embryonic placenta development	IMP	J:104483
Biological Process	GO:0051649	establishment of localization in cell	IMP	J:81443
Biological Process	GO:0051649	establishment of localization in cell	IMP	J:120848
Biological Process	GO:0007507	heart development	IMP	J:59314
Biological Process	GO:0001947	heart looping	ISO	J:164563
Biological Process	GO:0098662	inorganic cation transmembrane transport	ISO	J:164563
Biological Process	GO:0006874	intracellular calcium ion homeostasis	IMP	J:84691
Biological Process	GO:0001822	kidney development	IGI	J:188763
Biological Process	GO:0001822	kidney development	IMP	J:59314
Biological Process	GO:0001889	liver development	IGI	J:188763
Biological Process	GO:0006811	monoatomic ion transport	IEA	J:60000
Biological Process	GO:2000134	negative regulation of G1/S transition of mitotic cell cycle	ISO	J:164563
Biological Process	GO:0060315	negative regulation of ryanodine-sensitive calcium-release channel activity	IDA	J:120848
Biological Process	GO:0060674	placenta blood vessel development	IMP	J:165114
Biological Process	GO:0045737	positive regulation of cyclin-dependent protein serine/threonine kinase activity	ISO	J:164563
Biological Process	GO:0007204	positive regulation of cytosolic calcium ion concentration	ISO	J:155856
Biological Process	GO:0010628	positive regulation of gene expression	IMP	J:158762
Biological Process	GO:0031587	positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity	ISO	J:164563
Biological Process	GO:0045429	positive regulation of nitric oxide biosynthetic process	IMP	J:182484
Biological Process	GO:0045429	positive regulation of nitric oxide biosynthetic process	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0071805	potassium ion transmembrane transport	IMP	J:240321
Biological Process	GO:0071805	potassium ion transmembrane transport	ISO	J:164563
Biological Process	GO:0071805	potassium ion transmembrane transport	IBA	J:265628
Biological Process	GO:0006813	potassium ion transport	IEA	J:60000
Biological Process	GO:0051290	protein heterotetramerization	ISO	J:164563
Biological Process	GO:0051289	protein homotetramerization	ISO	J:164563
Biological Process	GO:0051262	protein tetramerization	ISO	J:164563
Biological Process	GO:0007259	receptor signaling pathway via JAK-STAT	EXP	J:76062
Biological Process	GO:0007259	receptor signaling pathway via JAK-STAT	IDA	J:76062
Biological Process	GO:0090279	regulation of calcium ion import	ISO	J:164563
Biological Process	GO:0051726	regulation of cell cycle	IDA	J:76062
Biological Process	GO:0042127	regulation of cell population proliferation	ISO	J:164563
Biological Process	GO:0034765	regulation of monoatomic ion transmembrane transport	IEA	J:60000
Biological Process	GO:0051209	release of sequestered calcium ion into cytosol	IMP	J:182484
Biological Process	GO:0051209	release of sequestered calcium ion into cytosol	ISO	J:164563
Biological Process	GO:0051209	release of sequestered calcium ion into cytosol	IBA	J:265628
Biological Process	GO:0051209	release of sequestered calcium ion into cytosol	IMP	J:120848
Biological Process	GO:0061333	renal tubule morphogenesis	IMP	J:158762
Biological Process	GO:0035725	sodium ion transmembrane transport	ISO	J:164563
Biological Process	GO:0016055	Wnt signaling pathway	IEA	J:60000