GO Annotations Graph

• Symbol: Tln1
• Name: talin 1
• ID: MGI:1099832

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003779	actin binding	IEA	J:72247
Molecular Function	GO:0051015	actin filament binding	IEA	J:72247
Molecular Function	GO:0005178	integrin binding	ISO	J:164563
Molecular Function	GO:0005178	integrin binding	IMP	J:158602
Molecular Function	GO:0005178	integrin binding	ISO	J:155856
Molecular Function	GO:0005178	integrin binding	IBA	J:265628
Molecular Function	GO:0030274	LIM domain binding	ISO	J:164563
Molecular Function	GO:0035091	phosphatidylinositol binding	IMP	J:158602
Molecular Function	GO:0001786	phosphatidylserine binding	IMP	J:158602
Molecular Function	GO:0005515	protein binding	IPI	J:245286
Molecular Function	GO:0005515	protein binding	IPI	J:116247
Molecular Function	GO:0005515	protein binding	IPI	J:245251
Molecular Function	GO:0005515	protein binding	IPI	J:160366
Molecular Function	GO:0005515	protein binding	IPI	J:247412
Molecular Function	GO:0005515	protein binding	IPI	J:200373
Molecular Function	GO:0005515	protein binding	IPI	J:245362
Molecular Function	GO:0005515	protein binding	IPI	J:180707
Molecular Function	GO:0005515	protein binding	IPI	J:245320
Molecular Function	GO:0005515	protein binding	IPI	J:118784
Molecular Function	GO:0005200	structural constituent of cytoskeleton	IEA	J:72247
Molecular Function	GO:0017166	vinculin binding	ISO	J:164563
Cellular Component	GO:0005912	adherens junction	ISO	J:164563
Cellular Component	GO:0030054	cell junction	IEA	J:60000
Cellular Component	GO:0042995	cell projection	IEA	J:60000
Cellular Component	GO:0005737	cytoplasm	IEA	J:60000
Cellular Component	GO:0005856	cytoskeleton	IEA	J:72247
Cellular Component	GO:0005856	cytoskeleton	IEA	J:60000
Cellular Component	GO:0005925	focal adhesion	ISO	J:164563
Cellular Component	GO:0005925	focal adhesion	IBA	J:265628
Cellular Component	GO:0005925	focal adhesion	IDA	J:80557
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005886	plasma membrane	IBA	J:265628
Cellular Component	GO:0001726	ruffle	IEA	J:72247
Biological Process	GO:0007155	cell adhesion	IEA	J:72247
Biological Process	GO:0098609	cell-cell adhesion	IBA	J:265628
Biological Process	GO:0007044	cell-substrate junction assembly	IMP	J:84472
Biological Process	GO:0030866	cortical actin cytoskeleton organization	IMP	J:84472
Biological Process	GO:0033622	integrin activation	IMP	J:158602
Biological Process	GO:0007229	integrin-mediated signaling pathway	IMP	J:158602