GO Annotations Graph

• Symbol: Bub1
• Name: BUB1, mitotic checkpoint serine/threonine kinase
• ID: MGI:1100510

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	IEA	J:72247
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0016301	kinase activity	IEA	J:60000
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0004672	protein kinase activity	IBA	J:265628
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IEA	J:72245
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IEA	J:60000
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Cellular Component	GO:0005694	chromosome	IEA	J:60000
Cellular Component	GO:0000775	chromosome, centromeric region	IDA	J:80450
Cellular Component	GO:0000779	condensed chromosome, centromeric region	IDA	J:130184
Cellular Component	GO:0000779	condensed chromosome, centromeric region	IDA	J:155745
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	ISO	J:164563
Cellular Component	GO:0000776	kinetochore	IDA	J:91435
Cellular Component	GO:0000776	kinetochore	IDA	J:135093
Cellular Component	GO:0000776	kinetochore	ISO	J:73065
Cellular Component	GO:0000776	kinetochore	ISO	J:73065
Cellular Component	GO:0000776	kinetochore	IDA	J:119076
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IEA	J:60000
Biological Process	GO:0006915	apoptotic process	IEA	J:60000
Biological Process	GO:0007049	cell cycle	IEA	J:60000
Biological Process	GO:0051301	cell division	IEA	J:60000
Biological Process	GO:0007059	chromosome segregation	IMP	J:135093
Biological Process	GO:0097193	intrinsic apoptotic signaling pathway	IMP	J:135093
Biological Process	GO:0051754	meiotic sister chromatid cohesion, centromeric	IBA	J:265628
Biological Process	GO:0007094	mitotic spindle assembly checkpoint signaling	IBA	J:265628
Biological Process	GO:0071174	mitotic spindle checkpoint signaling	IMP	J:135093
Biological Process	GO:0016310	phosphorylation	IEA	J:60000
Biological Process	GO:2001244	positive regulation of intrinsic apoptotic signaling pathway	IMP	J:135093
Biological Process	GO:0006468	protein phosphorylation	IEA	J:72247
Biological Process	GO:0051983	regulation of chromosome segregation	ISO	J:164563
Biological Process	GO:0007063	regulation of sister chromatid cohesion	ISO	J:164563