GO Annotations Graph

• Symbol: Dr1
• Name: down-regulator of transcription 1
• ID: MGI:1100515

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003677	DNA binding	IEA	J:60000
Molecular Function	GO:0140223	general transcription initiation factor activity	IEA	J:72247
Molecular Function	GO:0005515	protein binding	IPI	J:145720
Molecular Function	GO:0005515	protein binding	IPI	J:145720
Molecular Function	GO:0046982	protein heterodimerization activity	IEA	J:72247
Molecular Function	GO:0016251	RNA polymerase II general transcription initiation factor activity	ISO	J:164563
Molecular Function	GO:0016251	RNA polymerase II general transcription initiation factor activity	IBA	J:265628
Molecular Function	GO:0017025	TBP-class protein binding	ISO	J:164563
Molecular Function	GO:0017025	TBP-class protein binding	IBA	J:265628
Cellular Component	GO:0140672	ATAC complex	IDA	J:314756
Cellular Component	GO:0140672	ATAC complex	ISO	J:164563
Cellular Component	GO:0072686	mitotic spindle	NAS	J:162081
Cellular Component	GO:0017054	negative cofactor 2 complex	IBA	J:265628
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IDA	J:145720
Cellular Component	GO:0090575	RNA polymerase II transcription regulator complex	ISO	J:164563
Biological Process	GO:0006338	chromatin remodeling	IBA	J:265628
Biological Process	GO:0043966	histone H3 acetylation	ISO	J:164563
Biological Process	GO:0044154	histone H3-K14 acetylation	ISO	J:164563
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0051726	regulation of cell cycle	ISO	J:164563
Biological Process	GO:0051726	regulation of cell cycle	IMP	J:145720
Biological Process	GO:0051302	regulation of cell division	IDA	J:162081
Biological Process	GO:0051302	regulation of cell division	ISO	J:164563
Biological Process	GO:0006355	regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0045995	regulation of embryonic development	IDA	J:145720
Biological Process	GO:0031063	regulation of histone deacetylation	ISO	J:164563
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0090043	regulation of tubulin deacetylation	ISO	J:164563
Biological Process	GO:0051123	RNA polymerase II preinitiation complex assembly	IBA	J:265628