Smad7 GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

Smad7
SMAD family member 7
MGI:1100518

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0048185	activin binding	ISO	J:164563
Molecular Function	GO:0008013	beta-catenin binding	ISO	J:164563
Molecular Function	GO:0005518	collagen binding	IPI	J:86396
Molecular Function	GO:0005518	collagen binding	IPI	J:86396
Molecular Function	GO:0005518	collagen binding	IPI	J:86396
Molecular Function	GO:0070411	I-SMAD binding	ISO	J:164563
Molecular Function	GO:0070411	I-SMAD binding	IBA	J:265628
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:200447
Molecular Function	GO:0005515	protein binding	IPI	J:180466
Molecular Function	GO:0005515	protein binding	IPI	J:109361
Molecular Function	GO:0005515	protein binding	IPI	J:109361
Molecular Function	GO:0140416	transcription regulator inhibitor activity	ISO	J:164563
Molecular Function	GO:0140416	transcription regulator inhibitor activity	IBA	J:265628
Molecular Function	GO:0034713	type I transforming growth factor beta receptor binding	ISO	J:164563
Molecular Function	GO:0031625	ubiquitin protein ligase binding	ISO	J:155856
Molecular Function	GO:0031625	ubiquitin protein ligase binding	ISO	J:164563
Cellular Component	GO:0005912	adherens junction	ISO	J:164563
Cellular Component	GO:0005813	centrosome	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-NUL-2167872
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-NUL-2167888
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-NUL-2167890
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-NUL-2169016
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-NUL-2169036
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-NUL-2169043
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-NUL-2176393
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-NUL-2176396
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-NUL-2176427
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-NUL-2176428
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-NUL-2176431
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-NUL-2179307
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-NUL-2179313
Cellular Component	GO:0001650	fibrillar center	ISO	J:164563
Cellular Component	GO:0071144	heteromeric SMAD protein complex	IBA	J:265628
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-NUL-2167888
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-NUL-2169004
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-NUL-2169012
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-NUL-2169016
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-NUL-2176428
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-NUL-2176430
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-NUL-2186775
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IDA	J:109361
Cellular Component	GO:0005634	nucleus	IDA	J:154112
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0032991	protein-containing complex	ISO	J:198828
Cellular Component	GO:0032991	protein-containing complex	IDA	J:109361
Cellular Component	GO:0005667	transcription regulator complex	IEA	J:72247
Biological Process	GO:0034333	adherens junction assembly	ISO	J:164563
Biological Process	GO:0009653	anatomical structure morphogenesis	IBA	J:265628
Biological Process	GO:0048844	artery morphogenesis	IMP	J:145777
Biological Process	GO:0030154	cell differentiation	IBA	J:265628
Biological Process	GO:1990830	cellular response to leukemia inhibitory factor	IEP	J:163558
Biological Process	GO:0071560	cellular response to transforming growth factor beta stimulus	ISO	J:164563
Biological Process	GO:0071560	cellular response to transforming growth factor beta stimulus	IMP	J:204644
Biological Process	GO:0035556	intracellular signal transduction	ISO	J:155856
Biological Process	GO:0030514	negative regulation of BMP signaling pathway	ISO	J:164563
Biological Process	GO:0030514	negative regulation of BMP signaling pathway	IDA	J:157031
Biological Process	GO:1902731	negative regulation of chondrocyte proliferation	IDA	J:281197
Biological Process	GO:0043433	negative regulation of DNA-binding transcription factor activity	ISO	J:164563
Biological Process	GO:0030279	negative regulation of ossification	IDA	J:281197
Biological Process	GO:0060394	negative regulation of pathway-restricted SMAD protein phosphorylation	ISO	J:164563
Biological Process	GO:0033137	negative regulation of peptidyl-serine phosphorylation	IMP	J:204644
Biological Process	GO:0033137	negative regulation of peptidyl-serine phosphorylation	ISO	J:164563
Biological Process	GO:0010801	negative regulation of peptidyl-threonine phosphorylation	IMP	J:204644
Biological Process	GO:0010801	negative regulation of peptidyl-threonine phosphorylation	ISO	J:164563
Biological Process	GO:0031397	negative regulation of protein ubiquitination	ISO	J:164563
Biological Process	GO:0002725	negative regulation of T cell cytokine production	IMP	J:220376
Biological Process	GO:2000320	negative regulation of T-helper 17 cell differentiation	IMP	J:220376
Biological Process	GO:2000317	negative regulation of T-helper 17 type immune response	IMP	J:220376
Biological Process	GO:0010944	negative regulation of transcription by competitive promoter binding	ISO	J:164563
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	ISO	J:164563
Biological Process	GO:0051444	negative regulation of ubiquitin-protein transferase activity	ISO	J:164563
Biological Process	GO:0060389	pathway-restricted SMAD protein phosphorylation	IMP	J:145777
Biological Process	GO:0022409	positive regulation of cell-cell adhesion	IMP	J:204644
Biological Process	GO:0022409	positive regulation of cell-cell adhesion	ISO	J:164563
Biological Process	GO:1903043	positive regulation of chondrocyte hypertrophy	IDA	J:281197
Biological Process	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	ISO	J:164563
Biological Process	GO:0031398	positive regulation of protein ubiquitination	ISO	J:164563
Biological Process	GO:0050821	protein stabilization	ISO	J:164563
Biological Process	GO:0031503	protein-containing complex localization	ISO	J:164563
Biological Process	GO:0032925	regulation of activin receptor signaling pathway	ISO	J:164563
Biological Process	GO:0055117	regulation of cardiac muscle contraction	IMP	J:145777
Biological Process	GO:0006355	regulation of DNA-templated transcription	IEA	J:72247
Biological Process	GO:0010717	regulation of epithelial to mesenchymal transition	ISO	J:164563
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0017015	regulation of transforming growth factor beta receptor signaling pathway	ISO	J:155856
Biological Process	GO:0017015	regulation of transforming growth factor beta receptor signaling pathway	IC	J:145777
Biological Process	GO:0060373	regulation of ventricular cardiac muscle cell membrane depolarization	IC	J:145777
Biological Process	GO:0060395	SMAD protein signal transduction	IBA	J:265628
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	IBA	J:265628
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	IDA	J:72786
Biological Process	GO:0001657	ureteric bud development	IEP	J:95433
Biological Process	GO:0055010	ventricular cardiac muscle tissue morphogenesis	IMP	J:145777
Biological Process	GO:0060412	ventricular septum morphogenesis	IMP	J:145777

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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