GO Annotations Graph

• Symbol: Frs2
• Name: fibroblast growth factor receptor substrate 2
• ID: MGI:1100860

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005104	fibroblast growth factor receptor binding	IBA	J:265628
Molecular Function	GO:0005104	fibroblast growth factor receptor binding	ISO	J:73065
Molecular Function	GO:0005168	neurotrophin TRKA receptor binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:206901
Molecular Function	GO:0005515	protein binding	IPI	J:40779
Molecular Function	GO:0005515	protein binding	IPI	J:105250
Molecular Function	GO:0005515	protein binding	IPI	J:40779
Molecular Function	GO:0005068	transmembrane receptor protein tyrosine kinase adaptor activity	IBA	J:265628
Molecular Function	GO:0005068	transmembrane receptor protein tyrosine kinase adaptor activity	IDA	J:40779
Cellular Component	GO:0005912	adherens junction	ISO	J:164563
Cellular Component	GO:0005911	cell-cell junction	IBA	J:265628
Cellular Component	GO:0005911	cell-cell junction	IDA	J:203744
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005737	cytoplasm	IDA	J:40779
Cellular Component	GO:0005737	cytoplasm	IDA	J:98531
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-NUL-9031971
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005886	plasma membrane	IDA	J:98531
Cellular Component	GO:0005886	plasma membrane	IDA	J:40779
Biological Process	GO:0008595	anterior/posterior axis specification, embryo	IMP	J:98883
Biological Process	GO:0044344	cellular response to fibroblast growth factor stimulus	ISO	J:155856
Biological Process	GO:0008543	fibroblast growth factor receptor signaling pathway	IBA	J:265628
Biological Process	GO:0008543	fibroblast growth factor receptor signaling pathway	IGI	J:73116
Biological Process	GO:0008543	fibroblast growth factor receptor signaling pathway	ISO	J:73065
Biological Process	GO:0008543	fibroblast growth factor receptor signaling pathway	IGI	J:73116
Biological Process	GO:0008543	fibroblast growth factor receptor signaling pathway	IMP	J:189960
Biological Process	GO:0008543	fibroblast growth factor receptor signaling pathway	IGI	J:73116
Biological Process	GO:0008543	fibroblast growth factor receptor signaling pathway	IGI	J:128712
Biological Process	GO:0008543	fibroblast growth factor receptor signaling pathway	IGI	J:98883
Biological Process	GO:0030900	forebrain development	IMP	J:102930
Biological Process	GO:0001702	gastrulation with mouth forming second	IMP	J:98883
Biological Process	GO:0002088	lens development in camera-type eye	IMP	J:189960
Biological Process	GO:0070307	lens fiber cell development	IMP	J:189960
Biological Process	GO:0070307	lens fiber cell development	IGI	J:189960
Biological Process	GO:0046619	lens placode formation involved in camera-type eye formation	IMP	J:94724
Biological Process	GO:2000726	negative regulation of cardiac muscle cell differentiation	ISO	J:164563
Biological Process	GO:0007405	neuroblast proliferation	IGI	J:102930
Biological Process	GO:0007405	neuroblast proliferation	IMP	J:102930
Biological Process	GO:0001759	organ induction	IMP	J:94724
Biological Process	GO:0043410	positive regulation of MAPK cascade	IMP	J:131096
Biological Process	GO:0043410	positive regulation of MAPK cascade	IMP	J:94724
Biological Process	GO:0043410	positive regulation of MAPK cascade	IMP	J:98883
Biological Process	GO:0043410	positive regulation of MAPK cascade	IMP	J:98883
Biological Process	GO:1904707	positive regulation of vascular associated smooth muscle cell proliferation	ISO	J:155856
Biological Process	GO:0060527	prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis	IMP	J:131096
Biological Process	GO:0042981	regulation of apoptotic process	IMP	J:203744
Biological Process	GO:0042981	regulation of apoptotic process	IMP	J:203744
Biological Process	GO:0050678	regulation of epithelial cell proliferation	IMP	J:131096
Biological Process	GO:0070372	regulation of ERK1 and ERK2 cascade	IMP	J:203744
Biological Process	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	IDA	J:40779
Biological Process	GO:0003281	ventricular septum development	IMP	J:128712