GO Annotations Graph

• Symbol: Phox2b
• Name: paired-like homeobox 2b
• ID: MGI:1100882

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003677	DNA binding	IEA	J:72247
Molecular Function	GO:0003677	DNA binding	IEA	J:60000
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	ISO	J:164563
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	ISO	J:286599
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	IDA	J:286599
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	J:265628
Molecular Function	GO:0005515	protein binding	IPI	J:286599
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO	J:164563
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	ISO	J:164563
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	IBA	J:265628
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	ISO	J:164563
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	ISO	J:286599
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	IDA	J:286599
Cellular Component	GO:0000785	chromatin	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IDA	J:50258
Cellular Component	GO:0005634	nucleus	IDA	J:119681
Cellular Component	GO:0005634	nucleus	IDA	J:57952
Biological Process	GO:0048483	autonomic nervous system development	ISO	J:164563
Biological Process	GO:0048468	cell development	IMP	J:96531
Biological Process	GO:0021533	cell differentiation in hindbrain	IMP	J:128441
Biological Process	GO:0021533	cell differentiation in hindbrain	IMP	J:128441
Biological Process	GO:0008283	cell population proliferation	IMP	J:137017
Biological Process	GO:0071773	cellular response to BMP stimulus	IDA	J:153961
Biological Process	GO:0071542	dopaminergic neuron differentiation	IMP	J:55391
Biological Process	GO:0048894	efferent axon development in a lateral line nerve	IMP	J:107718
Biological Process	GO:0048484	enteric nervous system development	IMP	J:55391
Biological Process	GO:0010001	glial cell differentiation	IMP	J:137017
Biological Process	GO:0021934	hindbrain tangential cell migration	IMP	J:166770
Biological Process	GO:0048839	inner ear development	IMP	J:107718
Biological Process	GO:0021723	medullary reticular formation development	IEP	J:43772
Biological Process	GO:0097475	motor neuron migration	IMP	J:126634
Biological Process	GO:0007275	multicellular organism development	IEA	J:60000
Biological Process	GO:0045665	negative regulation of neuron differentiation	IGI	J:128441
Biological Process	GO:1904691	negative regulation of type B pancreatic cell proliferation	IMP	J:137017
Biological Process	GO:1901166	neural crest cell migration involved in autonomic nervous system development	IMP	J:55391
Biological Process	GO:0030182	neuron differentiation	IC	J:128441
Biological Process	GO:0030182	neuron differentiation	IMP	J:137017
Biological Process	GO:0030182	neuron differentiation	IGI	J:128441
Biological Process	GO:0030182	neuron differentiation	IGI	J:128441
Biological Process	GO:0030182	neuron differentiation	IMP	J:128441
Biological Process	GO:0030182	neuron differentiation	IMP	J:128441
Biological Process	GO:0030182	neuron differentiation	IGI	J:128441
Biological Process	GO:0003358	noradrenergic neuron development	IMP	J:130853
Biological Process	GO:0003357	noradrenergic neuron differentiation	IMP	J:55391
Biological Process	GO:0003357	noradrenergic neuron differentiation	IMP	J:166770
Biological Process	GO:0048486	parasympathetic nervous system development	IMP	J:55391
Biological Process	GO:0120162	positive regulation of cold-induced thermogenesis	IMP	J:262358
Biological Process	GO:0045666	positive regulation of neuron differentiation	IGI	J:128441
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:56277
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0006355	regulation of DNA-templated transcription	IEA	J:72247
Biological Process	GO:0010468	regulation of gene expression	IMP	J:130853
Biological Process	GO:0002087	regulation of respiratory gaseous exchange by nervous system process	IMP	J:155885
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IDA	J:286599
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	ISO	J:286599
Biological Process	GO:0060541	respiratory system development	IMP	J:155885
Biological Process	GO:0061452	retrotrapezoid nucleus neuron differentiation	IMP	J:155885
Biological Process	GO:0035914	skeletal muscle cell differentiation	IMP	J:178918
Biological Process	GO:0061549	sympathetic ganglion development	IMP	J:130853
Biological Process	GO:0048485	sympathetic nervous system development	IMP	J:55391
Biological Process	GO:0044342	type B pancreatic cell proliferation	IMP	J:137017