GO Annotations Graph

• Symbol: Kl
• Name: klotho
• ID: MGI:1101771

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0004566	beta-glucuronidase activity	IEA	J:72245
Molecular Function	GO:0017134	fibroblast growth factor binding	IPI	J:117479
Molecular Function	GO:0017134	fibroblast growth factor binding	ISO	J:164563
Molecular Function	GO:0017134	fibroblast growth factor binding	IBA	J:265628
Molecular Function	GO:0005104	fibroblast growth factor receptor binding	IPI	J:117479
Molecular Function	GO:0005104	fibroblast growth factor receptor binding	IBA	J:265628
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0016798	hydrolase activity, acting on glycosyl bonds	IEA	J:60000
Molecular Function	GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	IEA	J:72247
Molecular Function	GO:0005515	protein binding	IPI	J:123536
Molecular Function	GO:0005515	protein binding	IPI	J:156501
Molecular Function	GO:0005515	protein binding	IPI	J:117479
Molecular Function	GO:0005515	protein binding	IPI	J:110570
Molecular Function	GO:0005515	protein binding	IPI	J:110570
Molecular Function	GO:0005515	protein binding	IPI	J:110570
Cellular Component	GO:0005576	extracellular region	ISS	J:46369
Cellular Component	GO:0005615	extracellular space	IEA	J:72247
Cellular Component	GO:0016020	membrane	ISS	J:46369
Cellular Component	GO:0005886	plasma membrane	IEA	J:60000
Biological Process	GO:0002526	acute inflammatory response	ISO	J:155856
Biological Process	GO:0007568	aging	ISO	J:164563
Biological Process	GO:0055074	calcium ion homeostasis	IGI	J:183281
Biological Process	GO:0005975	carbohydrate metabolic process	IEA	J:72247
Biological Process	GO:0008340	determination of adult lifespan	IMP	J:44109
Biological Process	GO:0006112	energy reserve metabolic process	IMP	J:66078
Biological Process	GO:0006112	energy reserve metabolic process	IMP	J:66078
Biological Process	GO:0008543	fibroblast growth factor receptor signaling pathway	IBA	J:265628
Biological Process	GO:0008286	insulin receptor signaling pathway	IEA	J:72247
Biological Process	GO:0008152	metabolic process	IEA	J:60000
Biological Process	GO:0003085	negative regulation of systemic arterial blood pressure	ISO	J:155856
Biological Process	GO:0042421	norepinephrine biosynthetic process	ISO	J:155856
Biological Process	GO:0030501	positive regulation of bone mineralization	ISO	J:164563
Biological Process	GO:0090080	positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway	IGI	J:110570