GO Annotations Graph

• Symbol: Thbs4
• Name: thrombospondin 4
• ID: MGI:1101779

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005509	calcium ion binding	ISO	J:164563
Molecular Function	GO:0005518	collagen binding	ISO	J:155856
Molecular Function	GO:0005201	extracellular matrix structural constituent	RCA	J:265604
Molecular Function	GO:0001968	fibronectin binding	ISO	J:155856
Molecular Function	GO:0008083	growth factor activity	IEA	J:60000
Molecular Function	GO:0008201	heparin binding	ISO	J:164563
Molecular Function	GO:0042802	identical protein binding	ISO	J:155856
Molecular Function	GO:0005178	integrin binding	ISO	J:164563
Molecular Function	GO:0043237	laminin-1 binding	ISO	J:155856
Molecular Function	GO:0005515	protein binding	IPI	J:186160
Cellular Component	GO:0005604	basement membrane	ISO	J:164563
Cellular Component	GO:0062023	collagen-containing extracellular matrix	HDA	J:265604
Cellular Component	GO:0062023	collagen-containing extracellular matrix	IDA	J:187437
Cellular Component	GO:0005783	endoplasmic reticulum	IDA	J:186160
Cellular Component	GO:0031012	extracellular matrix	ISO	J:155856
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0005576	extracellular region	IEA	J:72247
Cellular Component	GO:0005615	extracellular space	ISO	J:164563
Cellular Component	GO:0005615	extracellular space	IDA	J:186160
Cellular Component	GO:0031594	neuromuscular junction	ISO	J:155856
Cellular Component	GO:0016529	sarcoplasmic reticulum	IDA	J:186160
Biological Process	GO:0048266	behavioral response to pain	IMP	J:201935
Biological Process	GO:0048266	behavioral response to pain	ISO	J:155856
Biological Process	GO:0007155	cell adhesion	IEA	J:72247
Biological Process	GO:0007155	cell adhesion	IEA	J:60000
Biological Process	GO:0071603	endothelial cell-cell adhesion	ISO	J:164563
Biological Process	GO:0051451	myoblast migration	ISO	J:164563
Biological Process	GO:0007399	nervous system development	ISO	J:155856
Biological Process	GO:0048812	neuron projection morphogenesis	ISO	J:155856
Biological Process	GO:0051781	positive regulation of cell division	IEA	J:60000
Biological Process	GO:0001938	positive regulation of endothelial cell proliferation	ISO	J:164563
Biological Process	GO:0090023	positive regulation of neutrophil chemotaxis	ISO	J:164563
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	ISO	J:164563
Biological Process	GO:0034103	regulation of tissue remodeling	IMP	J:187437
Biological Process	GO:0034976	response to endoplasmic reticulum stress	IMP	J:186160
Biological Process	GO:0034976	response to endoplasmic reticulum stress	IBA	J:265628
Biological Process	GO:0006986	response to unfolded protein	IEA	J:60000
Biological Process	GO:0048771	tissue remodeling	IEA	J:60000