GO Annotations Graph

• Symbol: Fxyd2
• Name: FXYD domain-containing ion transport regulator 2
• ID: MGI:1195260

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0099106	ion channel regulator activity	IEA	J:72247
Molecular Function	GO:0017080	sodium channel regulator activity	IBA	J:265628
Molecular Function	GO:0017080	sodium channel regulator activity	IMP	J:99929
Cellular Component	GO:0016323	basolateral plasma membrane	ISO	J:155856
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	ISO	J:155856
Cellular Component	GO:0016020	membrane	IDA	J:99929
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0005890	sodium:potassium-exchanging ATPase complex	ISO	J:155856
Biological Process	GO:0010248	establishment or maintenance of transmembrane electrochemical gradient	NAS	J:319965
Biological Process	GO:0098662	inorganic cation transmembrane transport	ISO	J:155856
Biological Process	GO:0006811	monoatomic ion transport	IEA	J:60000
Biological Process	GO:0008285	negative regulation of cell population proliferation	ISO	J:155856
Biological Process	GO:1903407	negative regulation of P-type sodium:potassium-exchanging transporter activity	ISO	J:155856
Biological Process	GO:0006813	potassium ion transport	IEA	J:60000
Biological Process	GO:1902600	proton transmembrane transport	NAS	J:319965
Biological Process	GO:0043269	regulation of monoatomic ion transport	IEA	J:72247
Biological Process	GO:1903406	regulation of P-type sodium:potassium-exchanging transporter activity	ISO	J:155856
Biological Process	GO:2000649	regulation of sodium ion transmembrane transporter activity	IBA	J:265628
Biological Process	GO:2000649	regulation of sodium ion transmembrane transporter activity	IMP	J:99929
Biological Process	GO:0006814	sodium ion transport	IEA	J:60000