GO Annotations Graph

• Symbol: Ilk
• Name: integrin linked kinase
• ID: MGI:1195267

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	IEA	J:72247
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0005178	integrin binding	ISO	J:155856
Molecular Function	GO:0016301	kinase activity	IEA	J:60000
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:154437
Molecular Function	GO:0005515	protein binding	IPI	J:154054
Molecular Function	GO:0005515	protein binding	IPI	J:197523
Molecular Function	GO:0005515	protein binding	IPI	J:198827
Molecular Function	GO:0005515	protein binding	IPI	J:279936
Molecular Function	GO:0005515	protein binding	IPI	J:198827
Molecular Function	GO:0005515	protein binding	IPI	J:80923
Molecular Function	GO:0005515	protein binding	IPI	J:80923
Molecular Function	GO:0005515	protein binding	IPI	J:88736
Molecular Function	GO:0005515	protein binding	IPI	J:94254
Molecular Function	GO:0019904	protein domain specific binding	ISO	J:155856
Molecular Function	GO:0004672	protein kinase activity	ISO	J:155856
Molecular Function	GO:0019901	protein kinase binding	ISO	J:164563
Molecular Function	GO:0004674	protein serine/threonine kinase activity	ISO	J:155856
Molecular Function	GO:0004674	protein serine/threonine kinase activity	ISO	J:164563
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IBA	J:265628
Molecular Function	GO:0004674	protein serine/threonine kinase activity	ISO	J:43595
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:155856
Molecular Function	GO:0017124	SH3 domain binding	ISO	J:155856
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Cellular Component	GO:0030424	axon	ISO	J:155856
Cellular Component	GO:0030054	cell junction	IEA	J:60000
Cellular Component	GO:0042995	cell projection	IEA	J:60000
Cellular Component	GO:0005911	cell-cell junction	ISO	J:155856
Cellular Component	GO:0043034	costamere	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0043198	dendritic shaft	ISO	J:155856
Cellular Component	GO:0005925	focal adhesion	ISO	J:164563
Cellular Component	GO:0005925	focal adhesion	ISO	J:155856
Cellular Component	GO:0005925	focal adhesion	IBA	J:265628
Cellular Component	GO:0005925	focal adhesion	IDA	J:199658
Cellular Component	GO:0005925	focal adhesion	IDA	J:94254
Cellular Component	GO:0005925	focal adhesion	IDA	J:80923
Cellular Component	GO:0005925	focal adhesion	ISO	J:70132
Cellular Component	GO:0030027	lamellipodium	IDA	J:189982
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0043025	neuronal cell body	ISO	J:155856
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IEA	J:60000
Cellular Component	GO:0032991	protein-containing complex	ISO	J:155856
Cellular Component	GO:0001725	stress fiber	ISO	J:155856
Cellular Component	GO:0001725	stress fiber	IBA	J:265628
Cellular Component	GO:0043195	terminal bouton	ISO	J:155856
Biological Process	GO:0001658	branching involved in ureteric bud morphogenesis	IDA	J:97651
Biological Process	GO:0000902	cell morphogenesis	ISO	J:164563
Biological Process	GO:0008283	cell population proliferation	IMP	J:84273
Biological Process	GO:0030030	cell projection organization	IMP	J:163221
Biological Process	GO:0007160	cell-matrix adhesion	IBA	J:265628
Biological Process	GO:0045197	establishment or maintenance of epithelial cell apical/basal polarity	IMP	J:82761
Biological Process	GO:0010761	fibroblast migration	IMP	J:199658
Biological Process	GO:0007229	integrin-mediated signaling pathway	ISO	J:155856
Biological Process	GO:0007229	integrin-mediated signaling pathway	IBA	J:265628
Biological Process	GO:0007229	integrin-mediated signaling pathway	ISO	J:43595
Biological Process	GO:0032288	myelin assembly	ISO	J:155856
Biological Process	GO:0022011	myelination in peripheral nervous system	IMP	J:163221
Biological Process	GO:0043066	negative regulation of apoptotic process	ISO	J:155856
Biological Process	GO:0010667	negative regulation of cardiac muscle cell apoptotic process	ISO	J:155856
Biological Process	GO:2000178	negative regulation of neural precursor cell proliferation	IGI	J:208112
Biological Process	GO:2000178	negative regulation of neural precursor cell proliferation	IMP	J:208112
Biological Process	GO:2000178	negative regulation of neural precursor cell proliferation	IMP	J:208112
Biological Process	GO:2000178	negative regulation of neural precursor cell proliferation	IGI	J:208112
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	ISO	J:155856
Biological Process	GO:0006469	negative regulation of protein kinase activity	ISO	J:155856
Biological Process	GO:0014912	negative regulation of smooth muscle cell migration	ISO	J:155856
Biological Process	GO:0048662	negative regulation of smooth muscle cell proliferation	ISO	J:155856
Biological Process	GO:0021675	nerve development	IMP	J:163221
Biological Process	GO:0061351	neural precursor cell proliferation	IMP	J:208112
Biological Process	GO:0061351	neural precursor cell proliferation	IGI	J:208112
Biological Process	GO:0061351	neural precursor cell proliferation	IMP	J:208112
Biological Process	GO:0061351	neural precursor cell proliferation	IGI	J:208112
Biological Process	GO:0048812	neuron projection morphogenesis	ISO	J:155856
Biological Process	GO:0003151	outflow tract morphogenesis	IMP	J:219045
Biological Process	GO:0018105	peptidyl-serine phosphorylation	ISO	J:155856
Biological Process	GO:0018105	peptidyl-serine phosphorylation	IMP	J:163221
Biological Process	GO:0016310	phosphorylation	IEA	J:60000
Biological Process	GO:0045773	positive regulation of axon extension	ISO	J:155856
Biological Process	GO:0050772	positive regulation of axonogenesis	ISO	J:155856
Biological Process	GO:0030513	positive regulation of BMP signaling pathway	IMP	J:172937
Biological Process	GO:0090263	positive regulation of canonical Wnt signaling pathway	ISO	J:164563
Biological Process	GO:0030335	positive regulation of cell migration	ISO	J:155856
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:155856
Biological Process	GO:0008284	positive regulation of cell population proliferation	IMP	J:84273
Biological Process	GO:0001954	positive regulation of cell-matrix adhesion	ISO	J:155856
Biological Process	GO:2000774	positive regulation of cellular senescence	ISO	J:155856
Biological Process	GO:0050775	positive regulation of dendrite morphogenesis	ISO	J:155856
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0043406	positive regulation of MAP kinase activity	ISO	J:155856
Biological Process	GO:0043410	positive regulation of MAPK cascade	ISO	J:155856
Biological Process	GO:0045663	positive regulation of myoblast differentiation	ISO	J:155856
Biological Process	GO:1901224	positive regulation of NIK/NF-kappaB signaling	ISO	J:164563
Biological Process	GO:0045669	positive regulation of osteoblast differentiation	IMP	J:172937
Biological Process	GO:0042327	positive regulation of phosphorylation	ISO	J:164563
Biological Process	GO:0051897	positive regulation of protein kinase B signaling	ISO	J:155856
Biological Process	GO:0001934	positive regulation of protein phosphorylation	ISO	J:164563
Biological Process	GO:0009967	positive regulation of signal transduction	ISO	J:164563
Biological Process	GO:1900026	positive regulation of substrate adhesion-dependent cell spreading	ISO	J:164563
Biological Process	GO:0043491	protein kinase B signaling	IMP	J:163221
Biological Process	GO:0006468	protein phosphorylation	ISO	J:164563
Biological Process	GO:0006468	protein phosphorylation	ISO	J:155856
Biological Process	GO:0032956	regulation of actin cytoskeleton organization	ISO	J:155856
Biological Process	GO:0051726	regulation of cell cycle	ISO	J:155856
Biological Process	GO:0001558	regulation of cell growth	ISO	J:155856
Biological Process	GO:0014044	Schwann cell development	IMP	J:163221
Biological Process	GO:0034446	substrate adhesion-dependent cell spreading	ISO	J:155856
Biological Process	GO:0034446	substrate adhesion-dependent cell spreading	ISO	J:164563
Biological Process	GO:0034446	substrate adhesion-dependent cell spreading	IBA	J:265628
Biological Process	GO:0097435	supramolecular fiber organization	ISO	J:155856
Biological Process	GO:0033209	tumor necrosis factor-mediated signaling pathway	ISO	J:164563