GO Annotations Graph

• Symbol: Aqp8
• Name: aquaporin 8
• ID: MGI:1195271

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0008519	ammonium transmembrane transporter activity	ISO	J:155856
Molecular Function	GO:0008519	ammonium transmembrane transporter activity	IMP	J:119872
Molecular Function	GO:0015267	channel activity	IEA	J:72247
Molecular Function	GO:0015264	methylammonium channel activity	ISO	J:155856
Molecular Function	GO:0015264	methylammonium channel activity	ISO	J:164563
Molecular Function	GO:0015265	urea channel activity	IDA	J:44349
Molecular Function	GO:0015250	water channel activity	IDA	J:44349
Molecular Function	GO:0015250	water channel activity	IMP	J:119872
Molecular Function	GO:0015250	water channel activity	IDA	J:331461
Molecular Function	GO:0015250	water channel activity	IMP	J:104681
Molecular Function	GO:0015250	water channel activity	ISO	J:164563
Molecular Function	GO:0015250	water channel activity	ISO	J:155856
Molecular Function	GO:0015250	water channel activity	IBA	J:265628
Molecular Function	GO:0015250	water channel activity	TAS	J:65472
Cellular Component	GO:0045177	apical part of cell	ISO	J:164563
Cellular Component	GO:0016324	apical plasma membrane	ISO	J:155856
Cellular Component	GO:0016324	apical plasma membrane	IDA	J:331969
Cellular Component	GO:0016323	basolateral plasma membrane	ISO	J:155856
Cellular Component	GO:0031526	brush border membrane	ISO	J:155856
Cellular Component	GO:0046691	intracellular canaliculus	ISO	J:164563
Cellular Component	GO:0046691	intracellular canaliculus	IDA	J:331462
Cellular Component	GO:0046691	intracellular canaliculus	ISO	J:155856
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	ISO	J:155856
Cellular Component	GO:0097708	intracellular vesicle	IDA	J:331462
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0005743	mitochondrial inner membrane	ISO	J:155856
Cellular Component	GO:0005743	mitochondrial inner membrane	ISO	J:164563
Cellular Component	GO:0031966	mitochondrial membrane	ISO	J:155856
Cellular Component	GO:0005739	mitochondrion	IDA	J:331969
Cellular Component	GO:0005739	mitochondrion	IDA	J:331462
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	IDA	J:104681
Cellular Component	GO:0005886	plasma membrane	IDA	J:331969
Cellular Component	GO:0005886	plasma membrane	IBA	J:265628
Cellular Component	GO:0005886	plasma membrane	TAS	J:65472
Cellular Component	GO:0005790	smooth endoplasmic reticulum	IDA	J:331462
Biological Process	GO:0140157	ammonium import across plasma membrane	ISO	J:155856
Biological Process	GO:0140157	ammonium import across plasma membrane	IDA	J:119872
Biological Process	GO:0072488	ammonium transmembrane transport	ISO	J:164563
Biological Process	GO:0072488	ammonium transmembrane transport	ISO	J:155856
Biological Process	GO:0030183	B cell differentiation	IMP	J:243242
Biological Process	GO:0015722	canalicular bile acid transport	ISO	J:155856
Biological Process	GO:1990748	cellular detoxification	ISO	J:164563
Biological Process	GO:0080170	hydrogen peroxide transmembrane transport	ISO	J:164563
Biological Process	GO:0080170	hydrogen peroxide transmembrane transport	ISO	J:155856
Biological Process	GO:0080170	hydrogen peroxide transmembrane transport	IMP	J:243242
Biological Process	GO:0072489	methylammonium transmembrane transport	ISO	J:155856
Biological Process	GO:0015843	methylammonium transport	ISO	J:155856
Biological Process	GO:0015843	methylammonium transport	ISO	J:164563
Biological Process	GO:0045540	regulation of cholesterol biosynthetic process	ISO	J:164563
Biological Process	GO:0035377	transepithelial water transport	ISO	J:155856
Biological Process	GO:0055085	transmembrane transport	IEA	J:72247
Biological Process	GO:0015840	urea transport	IDA	J:44349
Biological Process	GO:0006833	water transport	IDA	J:331461
Biological Process	GO:0006833	water transport	ISO	J:155856
Biological Process	GO:0006833	water transport	ISO	J:164563
Biological Process	GO:0006833	water transport	IDA	J:44349
Biological Process	GO:0006833	water transport	IMP	J:119872
Biological Process	GO:0006833	water transport	IBA	J:265628
Biological Process	GO:0006833	water transport	IMP	J:104681