GO Annotations Graph

• Symbol: Kdm1a
• Name: lysine (K)-specific demethylase 1A
• ID: MGI:1196256

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003682	chromatin binding	ISO	J:164563
Molecular Function	GO:0003682	chromatin binding	ISO	J:155856
Molecular Function	GO:0003682	chromatin binding	IBA	J:265628
Molecular Function	GO:0003682	chromatin binding	ISO	J:208295
Molecular Function	GO:0003682	chromatin binding	IDA	J:121427
Molecular Function	GO:0003682	chromatin binding	IDA	J:121427
Molecular Function	GO:0003682	chromatin binding	IDA	J:121427
Molecular Function	GO:0003682	chromatin binding	IDA	J:121427
Molecular Function	GO:0003682	chromatin binding	IDA	J:121427
Molecular Function	GO:0032451	demethylase activity	ISO	J:164563
Molecular Function	GO:0140297	DNA-binding transcription factor binding	ISO	J:164563
Molecular Function	GO:0140297	DNA-binding transcription factor binding	IPI	J:165849
Molecular Function	GO:0019899	enzyme binding	ISO	J:164563
Molecular Function	GO:0019899	enzyme binding	IPI	J:169894
Molecular Function	GO:0140682	FAD-dependent H3K4me/H3K4me3 demethylase activity	ISO	J:164563
Molecular Function	GO:0140682	FAD-dependent H3K4me/H3K4me3 demethylase activity	IDA	J:211358
Molecular Function	GO:0050660	flavin adenine dinucleotide binding	ISO	J:164563
Molecular Function	GO:0050660	flavin adenine dinucleotide binding	IBA	J:265628
Molecular Function	GO:0032452	histone demethylase activity	ISO	J:164563
Molecular Function	GO:0032453	histone H3K4 demethylase activity	ISO	J:164563
Molecular Function	GO:0032453	histone H3K4 demethylase activity	ISO	J:208295
Molecular Function	GO:0032453	histone H3K4 demethylase activity	IMP	J:208295
Molecular Function	GO:0032454	histone H3K9 demethylase activity	ISO	J:164563
Molecular Function	GO:0106222	lncRNA binding	IDA	J:240516
Molecular Function	GO:0043426	MRF binding	ISO	J:164563
Molecular Function	GO:0043426	MRF binding	IPI	J:165849
Molecular Function	GO:0050681	nuclear androgen receptor binding	ISO	J:164563
Molecular Function	GO:0030374	nuclear receptor coactivator activity	ISO	J:164563
Molecular Function	GO:0016491	oxidoreductase activity	ISO	J:164563
Molecular Function	GO:0016491	oxidoreductase activity	IBA	J:265628
Molecular Function	GO:0002039	p53 binding	ISO	J:164563
Molecular Function	GO:1990841	promoter-specific chromatin binding	IDA	J:150066
Molecular Function	GO:0005515	protein binding	IPI	J:240583
Molecular Function	GO:0005515	protein binding	IPI	J:156979
Molecular Function	GO:0005515	protein binding	IPI	J:160317
Molecular Function	GO:0005515	protein binding	IPI	J:236647
Molecular Function	GO:0005515	protein binding	IPI	J:245310
Molecular Function	GO:0005515	protein binding	IPI	J:237908
Molecular Function	GO:0005515	protein binding	IPI	J:122905
Molecular Function	GO:0005515	protein binding	IPI	J:121427
Molecular Function	GO:0005515	protein binding	IPI	J:215624
Molecular Function	GO:0005515	protein binding	IPI	J:211358
Molecular Function	GO:0005515	protein binding	IPI	J:211358
Molecular Function	GO:0005515	protein binding	IPI	J:121427
Molecular Function	GO:0005515	protein binding	IPI	J:211358
Molecular Function	GO:0005515	protein binding	IPI	J:121427
Molecular Function	GO:0005515	protein binding	IPI	J:121427
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	J:237908
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	IPI	J:161725
Molecular Function	GO:0061752	telomeric repeat-containing RNA binding	ISO	J:164563
Molecular Function	GO:0003714	transcription corepressor activity	IDA	J:175166
Molecular Function	GO:0008134	transcription factor binding	IBA	J:265628
Cellular Component	GO:0000785	chromatin	ISO	J:155856
Cellular Component	GO:0000785	chromatin	IDA	J:165849
Cellular Component	GO:0000785	chromatin	ISO	J:164563
Cellular Component	GO:0000781	chromosome, telomeric region	ISO	J:164563
Cellular Component	GO:1990391	DNA repair complex	ISO	J:208295
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IDA	J:237908
Cellular Component	GO:0005634	nucleus	IDA	J:150066
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0032991	protein-containing complex	ISO	J:208295
Biological Process	GO:0030154	cell differentiation	IMP	J:121427
Biological Process	GO:0071480	cellular response to gamma radiation	ISO	J:208295
Biological Process	GO:0034644	cellular response to UV	ISO	J:208295
Biological Process	GO:0006325	chromatin organization	IEA	J:60000
Biological Process	GO:0140861	DNA repair-dependent chromatin remodeling	ISO	J:208295
Biological Process	GO:0140861	DNA repair-dependent chromatin remodeling	IDA	J:208295
Biological Process	GO:0030851	granulocyte differentiation	IMP	J:175166
Biological Process	GO:0046098	guanine metabolic process	ISO	J:155856
Biological Process	GO:0034720	histone H3-K4 demethylation	IEA	J:72247
Biological Process	GO:0033169	histone H3-K9 demethylation	IMP	J:165849
Biological Process	GO:0016570	histone modification	ISO	J:155856
Biological Process	GO:0007275	multicellular organism development	IEA	J:60000
Biological Process	GO:0055001	muscle cell development	IMP	J:165849
Biological Process	GO:0043518	negative regulation of DNA damage response, signal transduction by p53 class mediator	ISO	J:164563
Biological Process	GO:0043433	negative regulation of DNA-binding transcription factor activity	ISO	J:164563
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0051572	negative regulation of histone H3-K4 methylation	IMP	J:161725
Biological Process	GO:0051573	negative regulation of histone H3-K9 methylation	IMP	J:161725
Biological Process	GO:1902166	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	ISO	J:164563
Biological Process	GO:0050768	negative regulation of neurogenesis	IMP	J:215624
Biological Process	GO:0050768	negative regulation of neurogenesis	IDA	J:215624
Biological Process	GO:0032091	negative regulation of protein binding	ISO	J:164563
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IDA	J:150066
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IMP	J:121427
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IMP	J:121427
Biological Process	GO:1990138	neuron projection extension	IMP	J:215624
Biological Process	GO:1990138	neuron projection extension	IGI	J:215624
Biological Process	GO:0021983	pituitary gland development	IMP	J:121427
Biological Process	GO:0045793	positive regulation of cell size	ISO	J:155856
Biological Process	GO:0035563	positive regulation of chromatin binding	ISO	J:155856
Biological Process	GO:0120162	positive regulation of cold-induced thermogenesis	IMP	J:235661
Biological Process	GO:0051091	positive regulation of DNA-binding transcription factor activity	ISO	J:164563
Biological Process	GO:0045648	positive regulation of erythrocyte differentiation	IMP	J:175166
Biological Process	GO:0045654	positive regulation of megakaryocyte differentiation	IMP	J:175166
Biological Process	GO:2000179	positive regulation of neural precursor cell proliferation	IMP	J:161725
Biological Process	GO:0002052	positive regulation of neuroblast proliferation	ISO	J:164563
Biological Process	GO:0010976	positive regulation of neuron projection development	ISO	J:155856
Biological Process	GO:0031398	positive regulation of protein ubiquitination	ISO	J:208295
Biological Process	GO:2000648	positive regulation of stem cell proliferation	IMP	J:161725
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:155856
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:121427
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:121427
Biological Process	GO:0006482	protein demethylation	ISO	J:164563
Biological Process	GO:0090308	regulation of DNA methylation-dependent heterochromatin formation	ISO	J:164563
Biological Process	GO:0006355	regulation of DNA-templated transcription	IEA	J:72247
Biological Process	GO:0010569	regulation of double-strand break repair via homologous recombination	ISO	J:208295
Biological Process	GO:0050767	regulation of neurogenesis	IGI	J:215624
Biological Process	GO:0010725	regulation of primitive erythrocyte differentiation	IMP	J:175166
Biological Process	GO:0032880	regulation of protein localization	ISO	J:208295
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0006366	transcription by RNA polymerase II	IMP	J:121427